Pharmacogenomics and pharmacotranscriptomics of acute leukemia in children: a path to personalized medicine
Апстракт
Personalized medicine is focused on research disciplines which contribute to the individualization of
therapy, like pharmacogenomics and pharmacotranscriptomics. Acute lymphoblastic leukemia (ALL) is
the most common malignancy of childhood. It is one of the pediatric malignancies with the highest cure
rate, but still a lethal outcome due to therapy accounts for 1- 3% of deaths. Further improvement of
treatment protocols is needed through implementation of pharmacogenomics and
pharmacotranscriptomics. Emerging high-throughput technologies, microarrays and next-generation
sequencing, have provided an enormous amount of molecular data with potential to be implemented in
childhood ALL treatment protocols. In the current review, we summarized the contribution of these
novel technologies to pharmacogenomics and pharmacotranscriptomics of childhood ALL. We have
presented data on molecular markers responsible for efficacy, side effects and toxicity of the drugs
commonly used for chil...dhood ALL treatment, i.e., glucocorticoid drugs, vincristine, asparaginase,
anthracyclines, thiopurines and methotrexate. Big data was generated using high-throughput
technologies, but their implementation in clinical practice is poor. Research efforts have to be focused
on data analysis and designing prediction model using machine learning algorithms. Bioinformatics
tools and implementation of artificial intelligence are expected to open the door wide for personalized
medicine in clinical practice of childhood ALL.
Кључне речи:
pharmacogenomics / pharmacotranscriptomics / high-throughput analysis / childhood acute lymphoblastic leukemiaИзвор:
Genetics & Applications, 2023, 7, 2 (Special edition), 93-Издавач:
- Sarajevo : Institute for Genetic Engineering and Biotechnology, University of Sarajevo
Напомена:
- Book of abstracts: International Conference of Biochemists and Molecular Biologists in Bosnia and Herzegovina - ABMBBIH May, 2023
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - CONF AU - Zukić, Branka PY - 2023 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1898 AB - Personalized medicine is focused on research disciplines which contribute to the individualization of therapy, like pharmacogenomics and pharmacotranscriptomics. Acute lymphoblastic leukemia (ALL) is the most common malignancy of childhood. It is one of the pediatric malignancies with the highest cure rate, but still a lethal outcome due to therapy accounts for 1- 3% of deaths. Further improvement of treatment protocols is needed through implementation of pharmacogenomics and pharmacotranscriptomics. Emerging high-throughput technologies, microarrays and next-generation sequencing, have provided an enormous amount of molecular data with potential to be implemented in childhood ALL treatment protocols. In the current review, we summarized the contribution of these novel technologies to pharmacogenomics and pharmacotranscriptomics of childhood ALL. We have presented data on molecular markers responsible for efficacy, side effects and toxicity of the drugs commonly used for childhood ALL treatment, i.e., glucocorticoid drugs, vincristine, asparaginase, anthracyclines, thiopurines and methotrexate. Big data was generated using high-throughput technologies, but their implementation in clinical practice is poor. Research efforts have to be focused on data analysis and designing prediction model using machine learning algorithms. Bioinformatics tools and implementation of artificial intelligence are expected to open the door wide for personalized medicine in clinical practice of childhood ALL. PB - Sarajevo : Institute for Genetic Engineering and Biotechnology, University of Sarajevo C3 - Genetics & Applications T1 - Pharmacogenomics and pharmacotranscriptomics of acute leukemia in children: a path to personalized medicine IS - 2 (Special edition) SP - 93 VL - 7 UR - https://hdl.handle.net/21.15107/rcub_imagine_1898 ER -
@conference{ author = "Zukić, Branka", year = "2023", abstract = "Personalized medicine is focused on research disciplines which contribute to the individualization of therapy, like pharmacogenomics and pharmacotranscriptomics. Acute lymphoblastic leukemia (ALL) is the most common malignancy of childhood. It is one of the pediatric malignancies with the highest cure rate, but still a lethal outcome due to therapy accounts for 1- 3% of deaths. Further improvement of treatment protocols is needed through implementation of pharmacogenomics and pharmacotranscriptomics. Emerging high-throughput technologies, microarrays and next-generation sequencing, have provided an enormous amount of molecular data with potential to be implemented in childhood ALL treatment protocols. In the current review, we summarized the contribution of these novel technologies to pharmacogenomics and pharmacotranscriptomics of childhood ALL. We have presented data on molecular markers responsible for efficacy, side effects and toxicity of the drugs commonly used for childhood ALL treatment, i.e., glucocorticoid drugs, vincristine, asparaginase, anthracyclines, thiopurines and methotrexate. Big data was generated using high-throughput technologies, but their implementation in clinical practice is poor. Research efforts have to be focused on data analysis and designing prediction model using machine learning algorithms. Bioinformatics tools and implementation of artificial intelligence are expected to open the door wide for personalized medicine in clinical practice of childhood ALL.", publisher = "Sarajevo : Institute for Genetic Engineering and Biotechnology, University of Sarajevo", journal = "Genetics & Applications", title = "Pharmacogenomics and pharmacotranscriptomics of acute leukemia in children: a path to personalized medicine", number = "2 (Special edition)", pages = "93", volume = "7", url = "https://hdl.handle.net/21.15107/rcub_imagine_1898" }
Zukić, B.. (2023). Pharmacogenomics and pharmacotranscriptomics of acute leukemia in children: a path to personalized medicine. in Genetics & Applications Sarajevo : Institute for Genetic Engineering and Biotechnology, University of Sarajevo., 7(2 (Special edition)), 93. https://hdl.handle.net/21.15107/rcub_imagine_1898
Zukić B. Pharmacogenomics and pharmacotranscriptomics of acute leukemia in children: a path to personalized medicine. in Genetics & Applications. 2023;7(2 (Special edition)):93. https://hdl.handle.net/21.15107/rcub_imagine_1898 .
Zukić, Branka, "Pharmacogenomics and pharmacotranscriptomics of acute leukemia in children: a path to personalized medicine" in Genetics & Applications, 7, no. 2 (Special edition) (2023):93, https://hdl.handle.net/21.15107/rcub_imagine_1898 .