Micronutrients, genetics and COVID-19
Само за регистроване кориснике
2023
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Purpose of review Marked inter-individual differences in the clinical manifestation of coronavirus disease 2019 (COVID-19) disease has initiated studies in the field of genetics. This review evaluates recent genetic evidence (predominantly in the last 18 months) related to micronutrients (vitamins and trace elements) and COVID-19. Recent findings AQ5 In patients infected with SARS-CoV-2 virus, altered circulating levels of micronutrients may serve as prognostic markers of disease severity. Mendelian randomization (MR) studies did not find significant effect of variable genetically predicted levels of micronutrients on COVID-19 phenotypes, however, recent clinical studies on COVID-19 point out to vitamin D and zinc supplementation as a nutritional strategy to reduce disease severity and mortality. Recent evidence also points to variants in vitamin D receptor (VDR) gene, most notably rs2228570 (FokI) ‘‘f’’ allele and rs7975232 (ApaI) ‘‘aa’’ genotype as poor prognostic markers. Summary S...ince several micronutrients were included in the COVID-19 therapy protocols, research in the field of nutrigenetics of micronutrients is in progress. Recent findings from MR studies prioritize genes involved in biological effect, such as the VDR gene, rather than micronutrient status in future research. Emerging evidence on nutrigenetic markers may improve patient stratification and inform nutritional strategies against severe COVID-19.
Кључне речи:
coronavirus disease 2019 / Mendelian randomization / microelements / nutrigenetics / vitaminsИзвор:
Current Opinion in Clinical Nutrition & Metabolic Care, 2023, 26, 4, 309-315Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200042 (Универзитет у Београду, Институт за молекуларну генетику и генетичко инжењерство) (RS-MESTD-inst-2020-200042)
Повезане информације:
- Повезани садржај
https://doi.org/10.1097/MCO.0000000000000942
URI
https://journals.lww.com/co-clinicalnutrition/Abstract/2023/07000/Micronutrients,_genetics_and_COVID_19.3.aspx#ContentAccessOptionshttps://imagine.imgge.bg.ac.rs/handle/123456789/1907
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Kotur, Nikola AU - Stanković, Biljana AU - Pavlović, Sonja PY - 2023 UR - https://journals.lww.com/co-clinicalnutrition/Abstract/2023/07000/Micronutrients,_genetics_and_COVID_19.3.aspx#ContentAccessOptions UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1907 AB - Purpose of review Marked inter-individual differences in the clinical manifestation of coronavirus disease 2019 (COVID-19) disease has initiated studies in the field of genetics. This review evaluates recent genetic evidence (predominantly in the last 18 months) related to micronutrients (vitamins and trace elements) and COVID-19. Recent findings AQ5 In patients infected with SARS-CoV-2 virus, altered circulating levels of micronutrients may serve as prognostic markers of disease severity. Mendelian randomization (MR) studies did not find significant effect of variable genetically predicted levels of micronutrients on COVID-19 phenotypes, however, recent clinical studies on COVID-19 point out to vitamin D and zinc supplementation as a nutritional strategy to reduce disease severity and mortality. Recent evidence also points to variants in vitamin D receptor (VDR) gene, most notably rs2228570 (FokI) ‘‘f’’ allele and rs7975232 (ApaI) ‘‘aa’’ genotype as poor prognostic markers. Summary Since several micronutrients were included in the COVID-19 therapy protocols, research in the field of nutrigenetics of micronutrients is in progress. Recent findings from MR studies prioritize genes involved in biological effect, such as the VDR gene, rather than micronutrient status in future research. Emerging evidence on nutrigenetic markers may improve patient stratification and inform nutritional strategies against severe COVID-19. T2 - Current Opinion in Clinical Nutrition & Metabolic Care T2 - Current Opinion in Clinical Nutrition & Metabolic Care T1 - Micronutrients, genetics and COVID-19 EP - 315 IS - 4 SP - 309 VL - 26 DO - 10.1097/MCO.0000000000000942 ER -
@article{ author = "Kotur, Nikola and Stanković, Biljana and Pavlović, Sonja", year = "2023", abstract = "Purpose of review Marked inter-individual differences in the clinical manifestation of coronavirus disease 2019 (COVID-19) disease has initiated studies in the field of genetics. This review evaluates recent genetic evidence (predominantly in the last 18 months) related to micronutrients (vitamins and trace elements) and COVID-19. Recent findings AQ5 In patients infected with SARS-CoV-2 virus, altered circulating levels of micronutrients may serve as prognostic markers of disease severity. Mendelian randomization (MR) studies did not find significant effect of variable genetically predicted levels of micronutrients on COVID-19 phenotypes, however, recent clinical studies on COVID-19 point out to vitamin D and zinc supplementation as a nutritional strategy to reduce disease severity and mortality. Recent evidence also points to variants in vitamin D receptor (VDR) gene, most notably rs2228570 (FokI) ‘‘f’’ allele and rs7975232 (ApaI) ‘‘aa’’ genotype as poor prognostic markers. Summary Since several micronutrients were included in the COVID-19 therapy protocols, research in the field of nutrigenetics of micronutrients is in progress. Recent findings from MR studies prioritize genes involved in biological effect, such as the VDR gene, rather than micronutrient status in future research. Emerging evidence on nutrigenetic markers may improve patient stratification and inform nutritional strategies against severe COVID-19.", journal = "Current Opinion in Clinical Nutrition & Metabolic Care, Current Opinion in Clinical Nutrition & Metabolic Care", title = "Micronutrients, genetics and COVID-19", pages = "315-309", number = "4", volume = "26", doi = "10.1097/MCO.0000000000000942" }
Kotur, N., Stanković, B.,& Pavlović, S.. (2023). Micronutrients, genetics and COVID-19. in Current Opinion in Clinical Nutrition & Metabolic Care, 26(4), 309-315. https://doi.org/10.1097/MCO.0000000000000942
Kotur N, Stanković B, Pavlović S. Micronutrients, genetics and COVID-19. in Current Opinion in Clinical Nutrition & Metabolic Care. 2023;26(4):309-315. doi:10.1097/MCO.0000000000000942 .
Kotur, Nikola, Stanković, Biljana, Pavlović, Sonja, "Micronutrients, genetics and COVID-19" in Current Opinion in Clinical Nutrition & Metabolic Care, 26, no. 4 (2023):309-315, https://doi.org/10.1097/MCO.0000000000000942 . .