Expression profiling of ANKRD1 in rhabdomyosarcoma cell lines

Abstract

Introduction: Rhabdomyosarcoma (RMS) is the most common soft tissue malignancy in children and adolescents. Respecting the age of the patients and the tumor aggressiveness, investigation of the molecular mechanisms of RMS tumorigenesis is essential, most notably due to the possible identification of novel therapeutic targets. To contribute to a better understanding of the molecular pathology of RMS, we investigated ANKRD1 (ankyrin repeat domain 1) gene, considered a potential RMS diagnostic marker. The changes in its expression are related to carcinogenesis and resistance to chemotherapy in several types of tumors.