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Preclinical validation of rilmenidine for repurposing in pancreatic ductal adenocarcinoma
| dc.creator | Grahovac, J. | |
| dc.creator | Živić, K. | |
| dc.creator | Pavlović, M. | |
| dc.creator | Ostojić, M. | |
| dc.creator | Đurić, A. | |
| dc.creator | Srdić Rajić, T. | |
| dc.creator | Pavić, Aleksandar | |
| dc.creator | Galun, D. | |
| dc.date.accessioned | 2023-06-27T11:51:34Z | |
| dc.date.available | 2023-06-27T11:51:34Z | |
| dc.date.issued | 2023 | |
| dc.identifier.issn | 1574-7891 | |
| dc.identifier.issn | 1878-0261 (Online) | |
| dc.identifier.uri | https://febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13471 | |
| dc.identifier.uri | https://imagine.imgge.bg.ac.rs/handle/123456789/1912 | |
| dc.description.abstract | Introduction: Pancreatic ductal adenocarcinoma (PDAC) has dismal prognosis, as there are no screening tests available, most often is diagnosed in the metastatic phase of the disease and is refractory to conventional, targeted and immunotherapy. We have examined the expression and role of the novel tumor suppressor nischarin (NISCH) in PDAC and the effects of treatment with the agonist rilmenidine (approved for treatment of hypertension) in order to determine the potential of nischarin agonists for repurposing in this deadly disease. | sr |
| dc.language.iso | en | sr |
| dc.publisher | Wiley | sr |
| dc.rights | openAccess | sr |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
| dc.source | Molecular oncology | sr |
| dc.title | Preclinical validation of rilmenidine for repurposing in pancreatic ductal adenocarcinoma | sr |
| dc.type | conferenceObject | sr |
| dc.rights.license | BY | sr |
| dc.citation.epage | 348 | |
| dc.citation.issue | Supplement 1 | |
| dc.citation.spage | 347 | |
| dc.citation.volume | 17 | |
| dc.description.other | EACR 2023: Innovative Cancer Science, 12-15 June 2023, Torino, Italy | sr |
| dc.identifier.doi | doi.org/10.1002/1878-0261.13471 | |
| dc.identifier.fulltext | https://imagine.imgge.bg.ac.rs/bitstream/id/261175/bitstream_261175.pdf | |
| dc.type.version | publishedVersion | sr |
