Synthesis, characterization, and in vivo evaluation of the anticancer activity of a series of 5- and 6-(halomethyl)-2,2′-bipyridine rhenium tricarbonyl complexes
Аутори
Sovari, Sara NasiriKolly, Isabelle
Schindler, Kevin
Đurić, Ana
Srdić-Rajić, Tatjana
Crochet, Aurelien
Pavić, Aleksandar
Zobi, Fabio
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
We report the synthesis, characterization, and in vivo evaluation of the anticancer activity of a series of 5- and 6-(halomethyl)-2,2′-bipyridine rhenium tricarbonyl complexes. The study was promoted in order to understand if the presence and position of a reactive halomethyl substituent on the diimine ligand system of fac-[Re(CO)3]+ species may be a key molecular feature for the design of active and non-toxic anticancer agents. Only compounds potentially able to undergo ligand-based alkylating reactions show significant antiproliferative activity against colorectal and pancreatic cell lines. Of the new species presented in this study, one compound (5-(chloromethyl)-2,2′-bipyridine derivative) shows significant inhibition of pancreatic tumour growth in vivo in zebrafish-Panc-1 xenografts. The complex is noticeably effective at 8 μM concentration, lower than its in vitro IC50 values, being also capable of inhibiting in vivo cancer cells dissemination.
Извор:
Dalton Transactions, 2023, 52, 20, 6934-6944Финансирање / пројекти:
- Financial support from the Swiss National Science Foundation (project# 200021_196967, K. S. and F. Z.),
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200042 (Универзитет у Београду, Институт за молекуларну генетику и генетичко инжењерство) (RS-MESTD-inst-2020-200042)
URI
https://pubs.rsc.org/en/content/articlelanding/2023/dt/d2dt04041ghttps://imagine.imgge.bg.ac.rs/handle/123456789/1981
Колекције
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Sovari, Sara Nasiri AU - Kolly, Isabelle AU - Schindler, Kevin AU - Đurić, Ana AU - Srdić-Rajić, Tatjana AU - Crochet, Aurelien AU - Pavić, Aleksandar AU - Zobi, Fabio PY - 2023 UR - https://pubs.rsc.org/en/content/articlelanding/2023/dt/d2dt04041g UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1981 AB - We report the synthesis, characterization, and in vivo evaluation of the anticancer activity of a series of 5- and 6-(halomethyl)-2,2′-bipyridine rhenium tricarbonyl complexes. The study was promoted in order to understand if the presence and position of a reactive halomethyl substituent on the diimine ligand system of fac-[Re(CO)3]+ species may be a key molecular feature for the design of active and non-toxic anticancer agents. Only compounds potentially able to undergo ligand-based alkylating reactions show significant antiproliferative activity against colorectal and pancreatic cell lines. Of the new species presented in this study, one compound (5-(chloromethyl)-2,2′-bipyridine derivative) shows significant inhibition of pancreatic tumour growth in vivo in zebrafish-Panc-1 xenografts. The complex is noticeably effective at 8 μM concentration, lower than its in vitro IC50 values, being also capable of inhibiting in vivo cancer cells dissemination. T2 - Dalton Transactions T1 - Synthesis, characterization, and in vivo evaluation of the anticancer activity of a series of 5- and 6-(halomethyl)-2,2′-bipyridine rhenium tricarbonyl complexes EP - 6944 IS - 20 SP - 6934 VL - 52 DO - 10.1039/D2DT04041G ER -
@article{ author = "Sovari, Sara Nasiri and Kolly, Isabelle and Schindler, Kevin and Đurić, Ana and Srdić-Rajić, Tatjana and Crochet, Aurelien and Pavić, Aleksandar and Zobi, Fabio", year = "2023", abstract = "We report the synthesis, characterization, and in vivo evaluation of the anticancer activity of a series of 5- and 6-(halomethyl)-2,2′-bipyridine rhenium tricarbonyl complexes. The study was promoted in order to understand if the presence and position of a reactive halomethyl substituent on the diimine ligand system of fac-[Re(CO)3]+ species may be a key molecular feature for the design of active and non-toxic anticancer agents. Only compounds potentially able to undergo ligand-based alkylating reactions show significant antiproliferative activity against colorectal and pancreatic cell lines. Of the new species presented in this study, one compound (5-(chloromethyl)-2,2′-bipyridine derivative) shows significant inhibition of pancreatic tumour growth in vivo in zebrafish-Panc-1 xenografts. The complex is noticeably effective at 8 μM concentration, lower than its in vitro IC50 values, being also capable of inhibiting in vivo cancer cells dissemination.", journal = "Dalton Transactions", title = "Synthesis, characterization, and in vivo evaluation of the anticancer activity of a series of 5- and 6-(halomethyl)-2,2′-bipyridine rhenium tricarbonyl complexes", pages = "6944-6934", number = "20", volume = "52", doi = "10.1039/D2DT04041G" }
Sovari, S. N., Kolly, I., Schindler, K., Đurić, A., Srdić-Rajić, T., Crochet, A., Pavić, A.,& Zobi, F.. (2023). Synthesis, characterization, and in vivo evaluation of the anticancer activity of a series of 5- and 6-(halomethyl)-2,2′-bipyridine rhenium tricarbonyl complexes. in Dalton Transactions, 52(20), 6934-6944. https://doi.org/10.1039/D2DT04041G
Sovari SN, Kolly I, Schindler K, Đurić A, Srdić-Rajić T, Crochet A, Pavić A, Zobi F. Synthesis, characterization, and in vivo evaluation of the anticancer activity of a series of 5- and 6-(halomethyl)-2,2′-bipyridine rhenium tricarbonyl complexes. in Dalton Transactions. 2023;52(20):6934-6944. doi:10.1039/D2DT04041G .
Sovari, Sara Nasiri, Kolly, Isabelle, Schindler, Kevin, Đurić, Ana, Srdić-Rajić, Tatjana, Crochet, Aurelien, Pavić, Aleksandar, Zobi, Fabio, "Synthesis, characterization, and in vivo evaluation of the anticancer activity of a series of 5- and 6-(halomethyl)-2,2′-bipyridine rhenium tricarbonyl complexes" in Dalton Transactions, 52, no. 20 (2023):6934-6944, https://doi.org/10.1039/D2DT04041G . .