Echocardiography-based Left Ventricle Cardiac Hypertrophy Simulations
Аутори
Milićević, BogdanMilošević, Miljan
Simić, Vladimir
Trifunović, Danijela
Stanković, Goran
Filipović, Nenad
Kojić, Miloš
Остала ауторства
Morić, IvanaĐorđević, Valentina
Конференцијски прилог (Објављена верзија)
,
© 2023 Institute of Molecular Genetics and Genetic Engineering, University of Belgrade
Метаподаци
Приказ свих података о документуАпстракт
Clinical scenarios can be evaluated using numerical modeling of the cardiac cycle prior to
experimental or clinical application. Changes in wall thickness, displacement fields, and general
cardiac function are all affected by hypertrophy. In our study, we calculated the effects of
eccentric and concentric hypertrophy and monitored changes in ventricular thickness and shape.
Concentric hypertrophy results in thicker walls, while eccentric hypertrophy results in thinner
walls. Passive stresses were calculated using recently established material modals based on
Holzapfel’s work. Our modeling approach is based on composite shell finite elements, allowing
easier and more efficient modeling compared to traditional 3D finite elements. A left ventricular
model was constructed using echocardiographic images. Our modeling technology is based on
accurate patient-specific geometries and realistic constitutive curves, so it can be used as the
basis for real-world applications. Our model c...an be used to test medical hypotheses about the
development of hypertrophy in healthy and diseased hearts under the influence of different
conditions and factors.
Кључне речи:
composite shell finite elements / echocardiography / left ventricle / cardiac hypertrophyИзвор:
4th Belgrade Bioinformatics Conference, 2023, 4, 43-43Издавач:
- Belgrade : Institute of molecular genetics and genetic engineering
Финансирање / пројекти:
- This research was supported by the European Union’s Horizon 2020 research and innovation programme under grant agreement No 952603 (http://sgabu.eu/).
- SILICOFCM - In Silico trials for drug tracing the effects of sarcomeric protein mutations leading to familial cardiomyopathy (EU-H2020-777204)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200107 (Универзитет у Крагујевцу, Факултет инжењерских наука) (RS-MESTD-inst-2020-200107)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200378 (Институт за информационе технологије, Крагујевац) (RS-MESTD-inst-2020-200378)
Напомена:
- Book of abstract: 4th Belgrade Bioinformatics Conference, June 19-23, 2023
Колекције
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - CONF AU - Milićević, Bogdan AU - Milošević, Miljan AU - Simić, Vladimir AU - Trifunović, Danijela AU - Stanković, Goran AU - Filipović, Nenad AU - Kojić, Miloš PY - 2023 UR - https://belbi.bg.ac.rs/ UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1988 AB - Clinical scenarios can be evaluated using numerical modeling of the cardiac cycle prior to experimental or clinical application. Changes in wall thickness, displacement fields, and general cardiac function are all affected by hypertrophy. In our study, we calculated the effects of eccentric and concentric hypertrophy and monitored changes in ventricular thickness and shape. Concentric hypertrophy results in thicker walls, while eccentric hypertrophy results in thinner walls. Passive stresses were calculated using recently established material modals based on Holzapfel’s work. Our modeling approach is based on composite shell finite elements, allowing easier and more efficient modeling compared to traditional 3D finite elements. A left ventricular model was constructed using echocardiographic images. Our modeling technology is based on accurate patient-specific geometries and realistic constitutive curves, so it can be used as the basis for real-world applications. Our model can be used to test medical hypotheses about the development of hypertrophy in healthy and diseased hearts under the influence of different conditions and factors. PB - Belgrade : Institute of molecular genetics and genetic engineering C3 - 4th Belgrade Bioinformatics Conference T1 - Echocardiography-based Left Ventricle Cardiac Hypertrophy Simulations EP - 43 SP - 43 VL - 4 UR - https://hdl.handle.net/21.15107/rcub_imagine_1988 ER -
@conference{ author = "Milićević, Bogdan and Milošević, Miljan and Simić, Vladimir and Trifunović, Danijela and Stanković, Goran and Filipović, Nenad and Kojić, Miloš", year = "2023", abstract = "Clinical scenarios can be evaluated using numerical modeling of the cardiac cycle prior to experimental or clinical application. Changes in wall thickness, displacement fields, and general cardiac function are all affected by hypertrophy. In our study, we calculated the effects of eccentric and concentric hypertrophy and monitored changes in ventricular thickness and shape. Concentric hypertrophy results in thicker walls, while eccentric hypertrophy results in thinner walls. Passive stresses were calculated using recently established material modals based on Holzapfel’s work. Our modeling approach is based on composite shell finite elements, allowing easier and more efficient modeling compared to traditional 3D finite elements. A left ventricular model was constructed using echocardiographic images. Our modeling technology is based on accurate patient-specific geometries and realistic constitutive curves, so it can be used as the basis for real-world applications. Our model can be used to test medical hypotheses about the development of hypertrophy in healthy and diseased hearts under the influence of different conditions and factors.", publisher = "Belgrade : Institute of molecular genetics and genetic engineering", journal = "4th Belgrade Bioinformatics Conference", title = "Echocardiography-based Left Ventricle Cardiac Hypertrophy Simulations", pages = "43-43", volume = "4", url = "https://hdl.handle.net/21.15107/rcub_imagine_1988" }
Milićević, B., Milošević, M., Simić, V., Trifunović, D., Stanković, G., Filipović, N.,& Kojić, M.. (2023). Echocardiography-based Left Ventricle Cardiac Hypertrophy Simulations. in 4th Belgrade Bioinformatics Conference Belgrade : Institute of molecular genetics and genetic engineering., 4, 43-43. https://hdl.handle.net/21.15107/rcub_imagine_1988
Milićević B, Milošević M, Simić V, Trifunović D, Stanković G, Filipović N, Kojić M. Echocardiography-based Left Ventricle Cardiac Hypertrophy Simulations. in 4th Belgrade Bioinformatics Conference. 2023;4:43-43. https://hdl.handle.net/21.15107/rcub_imagine_1988 .
Milićević, Bogdan, Milošević, Miljan, Simić, Vladimir, Trifunović, Danijela, Stanković, Goran, Filipović, Nenad, Kojić, Miloš, "Echocardiography-based Left Ventricle Cardiac Hypertrophy Simulations" in 4th Belgrade Bioinformatics Conference, 4 (2023):43-43, https://hdl.handle.net/21.15107/rcub_imagine_1988 .