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Acquired amegakaryocytic thrombocytopenia associated with proliferation of gamma/delta TCR+ T-lymphocytes and a BCR-ABL (p210) fusion transcript
dc.creator | Colović, M | |
dc.creator | Pavlović, Sonja | |
dc.creator | Kraguljac, N | |
dc.creator | Čolović, Nataša | |
dc.creator | Janković, G | |
dc.creator | Sefer, D | |
dc.creator | Tošić, Nataša | |
dc.date.accessioned | 2022-11-15T13:39:26Z | |
dc.date.available | 2022-11-15T13:39:26Z | |
dc.date.issued | 2004 | |
dc.identifier.issn | 0902-4441 | |
dc.identifier.uri | https://imagine.imgge.bg.ac.rs/handle/123456789/205 | |
dc.description.abstract | Acquired amegakaryocytic thrombocytopenia (AATP) in adults is a rare disorder characterized by severe thrombocytopenia and decreased or absent megakaryocytes in an otherwise normal bone marrow. We present a 44-yr-old man in whom the diagnosis of AATP was established in January 2001. Immunophenotyping of the peripheral blood lymphocytes showed a relative increase in the subpopulation of gamma/delta T-cell receptor (TCR) positive (gamma/delta TCR+) and (CD4, CD8) negative T lymphocytes, and PCR suggested a monoclonal pattern of TCR gamma chain gene rearrangement. Cytogenetic examination of his bone marrow cells showed a normal male karyotype but RT-PCR analysis revealed a BCR-ABL (p210) fusion transcript. The inhibition of CFU-Mk growth mediated by the patient's T lymphocytes indicated that the pathogenic mechanism for AATP could be an immunological attack on megakaryocyte progenitors where the gamma/delta TCR-positive T lymphocytes are directly involved. The case emphasizes the complex association of T-lymphocyte monoclonal proliferation and AATP. | en |
dc.publisher | Wiley, Hoboken | |
dc.rights | restrictedAccess | |
dc.source | European Journal of Haematology | |
dc.subject | T-lymphocytes | en |
dc.subject | gamma/delta TCR+ and BCR-ABL (p210) | en |
dc.subject | acquired amegakaryocytic thrombocytopenia | en |
dc.title | Acquired amegakaryocytic thrombocytopenia associated with proliferation of gamma/delta TCR+ T-lymphocytes and a BCR-ABL (p210) fusion transcript | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 375 | |
dc.citation.issue | 5 | |
dc.citation.other | 73(5): 372-375 | |
dc.citation.rank | M23 | |
dc.citation.spage | 372 | |
dc.citation.volume | 73 | |
dc.identifier.doi | 10.1111/j.1600-0609.2004.00316.x | |
dc.identifier.pmid | 15458517 | |
dc.identifier.scopus | 2-s2.0-5344251613 | |
dc.identifier.wos | 000224241000009 | |
dc.type.version | publishedVersion |