Antibiotic potential of the Ambigol Cyanobacterial natural product class and simplified synthetic analogs
Само за регистроване кориснике
2023
Аутори
Milzarek, Tobias M.Stevanović, Milena
Milivojević, Dušan
Vojnović, Sandra
Iliasov, Denis
Wolf, Diana
Mascher, Thorsten
Nikodinović-Runić, Jasmina
Gulder, Tobias A. M.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The ambigols are cyanobacterial natural products characterized by three polychlorinated aromatic building blocks connected by biaryl and biaryl ether bridges. All ambigols known to date possess promising biological activities. Most significantly, ambigol A was reported to have antibacterial activity against Gram-positive bacteria, such as Bacillus megaterium and B. subtilis. We established a diverse compound library for in-depth biological evaluation building on our previous bio- and total synthetic research on this natural product family. To explore the antimicrobial potential in detail and to determine initial structure–activity relationships of this product class, a large set of dimeric and trimeric compounds were screened against selected bacterial and Candida target strains. Our results reveal exceptional antibiotic activity of the ambigols, especially against challenging clinical isolates.
Кључне речи:
antibiotic screening / ambigols / drug-resistant Staphylococcus aureus / cell membrane integrityИзвор:
ACS Infectious Diseases, 2023Финансирање / пројекти:
- Изучавање микробиолошког диверзитета и карактеризација корисних срединских микроорганизама (RS-MESTD-Basic Research (BR or ON)-173048)
- DAAD (Deutscher 482 Akademischer Austauschdienst, Bilateral Project with the 483 Republic of Serbia to J.N.R. and T.A.M.G. − 2016/2017)
- German Research Foundation (DFG GU 1233/1-1)
Колекције
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Milzarek, Tobias M. AU - Stevanović, Milena AU - Milivojević, Dušan AU - Vojnović, Sandra AU - Iliasov, Denis AU - Wolf, Diana AU - Mascher, Thorsten AU - Nikodinović-Runić, Jasmina AU - Gulder, Tobias A. M. PY - 2023 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/2077 AB - The ambigols are cyanobacterial natural products characterized by three polychlorinated aromatic building blocks connected by biaryl and biaryl ether bridges. All ambigols known to date possess promising biological activities. Most significantly, ambigol A was reported to have antibacterial activity against Gram-positive bacteria, such as Bacillus megaterium and B. subtilis. We established a diverse compound library for in-depth biological evaluation building on our previous bio- and total synthetic research on this natural product family. To explore the antimicrobial potential in detail and to determine initial structure–activity relationships of this product class, a large set of dimeric and trimeric compounds were screened against selected bacterial and Candida target strains. Our results reveal exceptional antibiotic activity of the ambigols, especially against challenging clinical isolates. T2 - ACS Infectious Diseases T2 - ACS Infectious DiseasesACS Infect. Dis. T1 - Antibiotic potential of the Ambigol Cyanobacterial natural product class and simplified synthetic analogs DO - 10.1021/acsinfecdis.3c00232 ER -
@article{ author = "Milzarek, Tobias M. and Stevanović, Milena and Milivojević, Dušan and Vojnović, Sandra and Iliasov, Denis and Wolf, Diana and Mascher, Thorsten and Nikodinović-Runić, Jasmina and Gulder, Tobias A. M.", year = "2023", abstract = "The ambigols are cyanobacterial natural products characterized by three polychlorinated aromatic building blocks connected by biaryl and biaryl ether bridges. All ambigols known to date possess promising biological activities. Most significantly, ambigol A was reported to have antibacterial activity against Gram-positive bacteria, such as Bacillus megaterium and B. subtilis. We established a diverse compound library for in-depth biological evaluation building on our previous bio- and total synthetic research on this natural product family. To explore the antimicrobial potential in detail and to determine initial structure–activity relationships of this product class, a large set of dimeric and trimeric compounds were screened against selected bacterial and Candida target strains. Our results reveal exceptional antibiotic activity of the ambigols, especially against challenging clinical isolates.", journal = "ACS Infectious Diseases, ACS Infectious DiseasesACS Infect. Dis.", title = "Antibiotic potential of the Ambigol Cyanobacterial natural product class and simplified synthetic analogs", doi = "10.1021/acsinfecdis.3c00232" }
Milzarek, T. M., Stevanović, M., Milivojević, D., Vojnović, S., Iliasov, D., Wolf, D., Mascher, T., Nikodinović-Runić, J.,& Gulder, T. A. M.. (2023). Antibiotic potential of the Ambigol Cyanobacterial natural product class and simplified synthetic analogs. in ACS Infectious Diseases. https://doi.org/10.1021/acsinfecdis.3c00232
Milzarek TM, Stevanović M, Milivojević D, Vojnović S, Iliasov D, Wolf D, Mascher T, Nikodinović-Runić J, Gulder TAM. Antibiotic potential of the Ambigol Cyanobacterial natural product class and simplified synthetic analogs. in ACS Infectious Diseases. 2023;. doi:10.1021/acsinfecdis.3c00232 .
Milzarek, Tobias M., Stevanović, Milena, Milivojević, Dušan, Vojnović, Sandra, Iliasov, Denis, Wolf, Diana, Mascher, Thorsten, Nikodinović-Runić, Jasmina, Gulder, Tobias A. M., "Antibiotic potential of the Ambigol Cyanobacterial natural product class and simplified synthetic analogs" in ACS Infectious Diseases (2023), https://doi.org/10.1021/acsinfecdis.3c00232 . .