Development of nystatin-based antifungal, biodegradable polymer composite materials for food packaging via. melt processing approach
Аутори
Duarah, RituparnaAleksić, Ivana
Milivojević, Dušan
Rameshkumar, Saranya
Nikodinović-Runić, Jasmina
Padamati, Ramesh Babu
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Novel bio-based, biodegradable packaging material was developed with multi-functional properties of good mechanical strength, potent biocompatibility, and antifungal attributes, predominantly against fungi vital in food spoilage. Biodegradable polymer composites were prepared with a natural antifungal agent, nystatin (Nyst), by melt processing technique for the first time. Initially, Polycaprolactone (PCL) was melt-mixed with various percentages of nystatin to produce nystatin-encapsulated PCL composites (PCL/Nyst). The as-prepared PCL/Nyst composites were melt-mixed with polylactic acid (PLA) to produce nystatin PLA/PCL blend composites. Subsequently, the prepared composites were compression molded in the form of films (1 mm) for further characterization. The composite's structural properties were evaluated by SEM, FTIR, mechanical and thermal studies. In addition, the composites were tested in vitro against a panel of pathogenic fungi and for antibiofilm attributes, specifically agai...nst three Candida species (C. albicans ATCC10231, C. parapsilosis ATCC22019, and C. glabrata ATCC2001), and foodborne Penicillium sp. All the composites containing 2 to 20 wt% nystatin displayed good activity and sustained nystatin release for up to 4 days. Thus, the overall study demonstrates the potential application of natural antifungal agents in biodegradable polymers to produce novel composite films for antimicrobial packaging without inducing any toxicity, judged from the toxicity assay using nematode Caenorhabditis elegans.
Кључне речи:
antifungal / melt-mixing technique-biodegradable blends-packaging-antifungal properties / nystatin / polycaprolactone / polylactic acidИзвор:
Journal of Applied Polymer Science, 2023, e54663-Издавач:
- Wiley
Финансирање / пројекти:
- research grant from Science Foundation Ireland (SFI) under Grant Number SFI/16/RC/3889 (BiOrbic)
- m European Union's Horizon 2020 research and innovation program under grant agreement No. 870292 (BioICEP)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200026 (Универзитет у Београду, Институт за хемију, технологију и металургију - ИХТМ) (RS-MESTD-inst-2020-200026)
- Environmental Protection Agency, grant number 2019- RE-LS-4
- Open access funding provided by IReL
Колекције
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Duarah, Rituparna AU - Aleksić, Ivana AU - Milivojević, Dušan AU - Rameshkumar, Saranya AU - Nikodinović-Runić, Jasmina AU - Padamati, Ramesh Babu PY - 2023 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/2079 AB - Novel bio-based, biodegradable packaging material was developed with multi-functional properties of good mechanical strength, potent biocompatibility, and antifungal attributes, predominantly against fungi vital in food spoilage. Biodegradable polymer composites were prepared with a natural antifungal agent, nystatin (Nyst), by melt processing technique for the first time. Initially, Polycaprolactone (PCL) was melt-mixed with various percentages of nystatin to produce nystatin-encapsulated PCL composites (PCL/Nyst). The as-prepared PCL/Nyst composites were melt-mixed with polylactic acid (PLA) to produce nystatin PLA/PCL blend composites. Subsequently, the prepared composites were compression molded in the form of films (1 mm) for further characterization. The composite's structural properties were evaluated by SEM, FTIR, mechanical and thermal studies. In addition, the composites were tested in vitro against a panel of pathogenic fungi and for antibiofilm attributes, specifically against three Candida species (C. albicans ATCC10231, C. parapsilosis ATCC22019, and C. glabrata ATCC2001), and foodborne Penicillium sp. All the composites containing 2 to 20 wt% nystatin displayed good activity and sustained nystatin release for up to 4 days. Thus, the overall study demonstrates the potential application of natural antifungal agents in biodegradable polymers to produce novel composite films for antimicrobial packaging without inducing any toxicity, judged from the toxicity assay using nematode Caenorhabditis elegans. PB - Wiley T2 - Journal of Applied Polymer Science T1 - Development of nystatin-based antifungal, biodegradable polymer composite materials for food packaging via. melt processing approach SP - e54663 DO - 10.1002/app.54663 ER -
@article{ author = "Duarah, Rituparna and Aleksić, Ivana and Milivojević, Dušan and Rameshkumar, Saranya and Nikodinović-Runić, Jasmina and Padamati, Ramesh Babu", year = "2023", abstract = "Novel bio-based, biodegradable packaging material was developed with multi-functional properties of good mechanical strength, potent biocompatibility, and antifungal attributes, predominantly against fungi vital in food spoilage. Biodegradable polymer composites were prepared with a natural antifungal agent, nystatin (Nyst), by melt processing technique for the first time. Initially, Polycaprolactone (PCL) was melt-mixed with various percentages of nystatin to produce nystatin-encapsulated PCL composites (PCL/Nyst). The as-prepared PCL/Nyst composites were melt-mixed with polylactic acid (PLA) to produce nystatin PLA/PCL blend composites. Subsequently, the prepared composites were compression molded in the form of films (1 mm) for further characterization. The composite's structural properties were evaluated by SEM, FTIR, mechanical and thermal studies. In addition, the composites were tested in vitro against a panel of pathogenic fungi and for antibiofilm attributes, specifically against three Candida species (C. albicans ATCC10231, C. parapsilosis ATCC22019, and C. glabrata ATCC2001), and foodborne Penicillium sp. All the composites containing 2 to 20 wt% nystatin displayed good activity and sustained nystatin release for up to 4 days. Thus, the overall study demonstrates the potential application of natural antifungal agents in biodegradable polymers to produce novel composite films for antimicrobial packaging without inducing any toxicity, judged from the toxicity assay using nematode Caenorhabditis elegans.", publisher = "Wiley", journal = "Journal of Applied Polymer Science", title = "Development of nystatin-based antifungal, biodegradable polymer composite materials for food packaging via. melt processing approach", pages = "e54663", doi = "10.1002/app.54663" }
Duarah, R., Aleksić, I., Milivojević, D., Rameshkumar, S., Nikodinović-Runić, J.,& Padamati, R. B.. (2023). Development of nystatin-based antifungal, biodegradable polymer composite materials for food packaging via. melt processing approach. in Journal of Applied Polymer Science Wiley., e54663. https://doi.org/10.1002/app.54663
Duarah R, Aleksić I, Milivojević D, Rameshkumar S, Nikodinović-Runić J, Padamati RB. Development of nystatin-based antifungal, biodegradable polymer composite materials for food packaging via. melt processing approach. in Journal of Applied Polymer Science. 2023;:e54663. doi:10.1002/app.54663 .
Duarah, Rituparna, Aleksić, Ivana, Milivojević, Dušan, Rameshkumar, Saranya, Nikodinović-Runić, Jasmina, Padamati, Ramesh Babu, "Development of nystatin-based antifungal, biodegradable polymer composite materials for food packaging via. melt processing approach" in Journal of Applied Polymer Science (2023):e54663, https://doi.org/10.1002/app.54663 . .