Is miR-133a marker of progressive chronic kidney disease?
Authors
Stopić, BojanDragičević, Sandra
Medić Brkić. Branislava
Nikolić, Aleksandra
Budisavljević, Sreten
Marković Nikolić, Natasa
Dimković, Nada
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Chronic kidney disease (CKD) is associated with a high incidence of cardiovascular (CV) disease and numerous risk factor have been implicated to play a role. Recent studies have shown that the levels of various microRNAs in the serum of patients with CKD have been altered and there are reports that miR-133a serum levels correlated with left ventricular hypertrophy in hemodialysis patients.The aim of this study was to investigate association between circulating miR-133a levels and development of de novo CV events in patients with CKD stage 3-5HD.METHODS: This study included 51 patients with diagnosed CKD and 7 healthy individuals as controls. According to the estimated glomerular filtration ratio (eGFR) patients were divided into three equal subgroups (n=17): patients with CKD stage 3b, 4, and 5HD. The level of miR-133a was measured in serum by quantitative real-time PCR. Echo parameters were measured by cardiac ultrasound at the beginning and after 12 months of follow-up. The followi...ng CV events were reported during 18 months of follow-up: cardiac death, myocardial infarction, cerebrovascular insult, exacerbation of existing and newly discovered angina pectoris and peripheral arterial disease.
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Nephrology Dialysis Transplantation, 56th ERA-EDTA Congress Abstracts, 2019, 34, Supplement_1, FP177-Publisher:
- Oxford University Press
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Institut za molekularnu genetiku i genetičko inženjerstvoTY - CONF AU - Stopić, Bojan AU - Dragičević, Sandra AU - Medić Brkić. Branislava AU - Nikolić, Aleksandra AU - Budisavljević, Sreten AU - Marković Nikolić, Natasa AU - Dimković, Nada PY - 2019 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/2080 AB - Chronic kidney disease (CKD) is associated with a high incidence of cardiovascular (CV) disease and numerous risk factor have been implicated to play a role. Recent studies have shown that the levels of various microRNAs in the serum of patients with CKD have been altered and there are reports that miR-133a serum levels correlated with left ventricular hypertrophy in hemodialysis patients.The aim of this study was to investigate association between circulating miR-133a levels and development of de novo CV events in patients with CKD stage 3-5HD.METHODS: This study included 51 patients with diagnosed CKD and 7 healthy individuals as controls. According to the estimated glomerular filtration ratio (eGFR) patients were divided into three equal subgroups (n=17): patients with CKD stage 3b, 4, and 5HD. The level of miR-133a was measured in serum by quantitative real-time PCR. Echo parameters were measured by cardiac ultrasound at the beginning and after 12 months of follow-up. The following CV events were reported during 18 months of follow-up: cardiac death, myocardial infarction, cerebrovascular insult, exacerbation of existing and newly discovered angina pectoris and peripheral arterial disease. PB - Oxford University Press C3 - Nephrology Dialysis Transplantation, 56th ERA-EDTA Congress Abstracts T1 - Is miR-133a marker of progressive chronic kidney disease? IS - Supplement_1 SP - FP177 VL - 34 DO - 10.1093/ndt/gfz106.FP177 ER -
@conference{ author = "Stopić, Bojan and Dragičević, Sandra and Medić Brkić. Branislava and Nikolić, Aleksandra and Budisavljević, Sreten and Marković Nikolić, Natasa and Dimković, Nada", year = "2019", abstract = "Chronic kidney disease (CKD) is associated with a high incidence of cardiovascular (CV) disease and numerous risk factor have been implicated to play a role. Recent studies have shown that the levels of various microRNAs in the serum of patients with CKD have been altered and there are reports that miR-133a serum levels correlated with left ventricular hypertrophy in hemodialysis patients.The aim of this study was to investigate association between circulating miR-133a levels and development of de novo CV events in patients with CKD stage 3-5HD.METHODS: This study included 51 patients with diagnosed CKD and 7 healthy individuals as controls. According to the estimated glomerular filtration ratio (eGFR) patients were divided into three equal subgroups (n=17): patients with CKD stage 3b, 4, and 5HD. The level of miR-133a was measured in serum by quantitative real-time PCR. Echo parameters were measured by cardiac ultrasound at the beginning and after 12 months of follow-up. The following CV events were reported during 18 months of follow-up: cardiac death, myocardial infarction, cerebrovascular insult, exacerbation of existing and newly discovered angina pectoris and peripheral arterial disease.", publisher = "Oxford University Press", journal = "Nephrology Dialysis Transplantation, 56th ERA-EDTA Congress Abstracts", title = "Is miR-133a marker of progressive chronic kidney disease?", number = "Supplement_1", pages = "FP177", volume = "34", doi = "10.1093/ndt/gfz106.FP177" }
Stopić, B., Dragičević, S., Medić Brkić. Branislava, Nikolić, A., Budisavljević, S., Marković Nikolić, N.,& Dimković, N.. (2019). Is miR-133a marker of progressive chronic kidney disease?. in Nephrology Dialysis Transplantation, 56th ERA-EDTA Congress Abstracts Oxford University Press., 34(Supplement_1), FP177. https://doi.org/10.1093/ndt/gfz106.FP177
Stopić B, Dragičević S, Medić Brkić. Branislava, Nikolić A, Budisavljević S, Marković Nikolić N, Dimković N. Is miR-133a marker of progressive chronic kidney disease?. in Nephrology Dialysis Transplantation, 56th ERA-EDTA Congress Abstracts. 2019;34(Supplement_1):FP177. doi:10.1093/ndt/gfz106.FP177 .
Stopić, Bojan, Dragičević, Sandra, Medić Brkić. Branislava, Nikolić, Aleksandra, Budisavljević, Sreten, Marković Nikolić, Natasa, Dimković, Nada, "Is miR-133a marker of progressive chronic kidney disease?" in Nephrology Dialysis Transplantation, 56th ERA-EDTA Congress Abstracts, 34, no. Supplement_1 (2019):FP177, https://doi.org/10.1093/ndt/gfz106.FP177 . .