The Role of Autophagy and Apoptosis in Affected Skin and Lungs in Patients with Systemic Sclerosis
Аутори
Spasovski, VesnaAnđelković, Marina
Parezanović, Marina
Komazec, Jovana
Ugrin, Milena
Klaassen, Kristel
Stojiljković, Maja
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Systemic sclerosis (SSc) is a complex autoimmune inflammatory disorder with multiple organ involvement. Skin changes present the hallmark of SSc and coincide with poor prognosis. Interstitial lung diseases (ILD) are the most widely reported complications in SSc patients and the primary cause of death. It has been proposed that the processes of autophagy and apoptosis could play a significant role in the pathogenesis and clinical course of different autoimmune diseases, and accordingly in SSc. In this manuscript, we review the current knowledge of autophagy and apoptosis processes in the skin and lungs of patients with SSc. Profiling of markers involved in these processes in skin cells can be useful to recognize the stage of fibrosis and can be used in the clinical stratification of patients. Furthermore, the knowledge of the molecular mechanisms underlying these processes enables the repurposing of already known drugs and the development of new biological therapeutics that aim to rever...se fibrosis by promoting apoptosis and regulate autophagy in personalized treatment approach. In SSc-ILD patients, the molecular signature of the lung tissues of each patient could be a distinctive criterion in order to establish the correct lung pattern, which directly impacts the course and prognosis of the disease. In this case, resolving the role of tissue-specific markers, which could be detected in the circulation using sensitive molecular methods, would be an important step toward development of non-invasive diagnostic procedures that enable early and precise diagnosis and preventing the high mortality of this rare disease.
Кључне речи:
apoptosis / autophagy / skin fibrosis / SSc / SSc-ILDИзвор:
International Journal of Molecular Sciences, 2023, 24, 13, 11212-Издавач:
- MDPI
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200042 (Универзитет у Београду, Институт за молекуларну генетику и генетичко инжењерство) (RS-MESTD-inst-2020-200042)
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Spasovski, Vesna AU - Anđelković, Marina AU - Parezanović, Marina AU - Komazec, Jovana AU - Ugrin, Milena AU - Klaassen, Kristel AU - Stojiljković, Maja PY - 2023 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/2085 AB - Systemic sclerosis (SSc) is a complex autoimmune inflammatory disorder with multiple organ involvement. Skin changes present the hallmark of SSc and coincide with poor prognosis. Interstitial lung diseases (ILD) are the most widely reported complications in SSc patients and the primary cause of death. It has been proposed that the processes of autophagy and apoptosis could play a significant role in the pathogenesis and clinical course of different autoimmune diseases, and accordingly in SSc. In this manuscript, we review the current knowledge of autophagy and apoptosis processes in the skin and lungs of patients with SSc. Profiling of markers involved in these processes in skin cells can be useful to recognize the stage of fibrosis and can be used in the clinical stratification of patients. Furthermore, the knowledge of the molecular mechanisms underlying these processes enables the repurposing of already known drugs and the development of new biological therapeutics that aim to reverse fibrosis by promoting apoptosis and regulate autophagy in personalized treatment approach. In SSc-ILD patients, the molecular signature of the lung tissues of each patient could be a distinctive criterion in order to establish the correct lung pattern, which directly impacts the course and prognosis of the disease. In this case, resolving the role of tissue-specific markers, which could be detected in the circulation using sensitive molecular methods, would be an important step toward development of non-invasive diagnostic procedures that enable early and precise diagnosis and preventing the high mortality of this rare disease. PB - MDPI T2 - International Journal of Molecular Sciences T1 - The Role of Autophagy and Apoptosis in Affected Skin and Lungs in Patients with Systemic Sclerosis IS - 13 SP - 11212 VL - 24 DO - 10.3390/ijms241311212 ER -
@article{ author = "Spasovski, Vesna and Anđelković, Marina and Parezanović, Marina and Komazec, Jovana and Ugrin, Milena and Klaassen, Kristel and Stojiljković, Maja", year = "2023", abstract = "Systemic sclerosis (SSc) is a complex autoimmune inflammatory disorder with multiple organ involvement. Skin changes present the hallmark of SSc and coincide with poor prognosis. Interstitial lung diseases (ILD) are the most widely reported complications in SSc patients and the primary cause of death. It has been proposed that the processes of autophagy and apoptosis could play a significant role in the pathogenesis and clinical course of different autoimmune diseases, and accordingly in SSc. In this manuscript, we review the current knowledge of autophagy and apoptosis processes in the skin and lungs of patients with SSc. Profiling of markers involved in these processes in skin cells can be useful to recognize the stage of fibrosis and can be used in the clinical stratification of patients. Furthermore, the knowledge of the molecular mechanisms underlying these processes enables the repurposing of already known drugs and the development of new biological therapeutics that aim to reverse fibrosis by promoting apoptosis and regulate autophagy in personalized treatment approach. In SSc-ILD patients, the molecular signature of the lung tissues of each patient could be a distinctive criterion in order to establish the correct lung pattern, which directly impacts the course and prognosis of the disease. In this case, resolving the role of tissue-specific markers, which could be detected in the circulation using sensitive molecular methods, would be an important step toward development of non-invasive diagnostic procedures that enable early and precise diagnosis and preventing the high mortality of this rare disease.", publisher = "MDPI", journal = "International Journal of Molecular Sciences", title = "The Role of Autophagy and Apoptosis in Affected Skin and Lungs in Patients with Systemic Sclerosis", number = "13", pages = "11212", volume = "24", doi = "10.3390/ijms241311212" }
Spasovski, V., Anđelković, M., Parezanović, M., Komazec, J., Ugrin, M., Klaassen, K.,& Stojiljković, M.. (2023). The Role of Autophagy and Apoptosis in Affected Skin and Lungs in Patients with Systemic Sclerosis. in International Journal of Molecular Sciences MDPI., 24(13), 11212. https://doi.org/10.3390/ijms241311212
Spasovski V, Anđelković M, Parezanović M, Komazec J, Ugrin M, Klaassen K, Stojiljković M. The Role of Autophagy and Apoptosis in Affected Skin and Lungs in Patients with Systemic Sclerosis. in International Journal of Molecular Sciences. 2023;24(13):11212. doi:10.3390/ijms241311212 .
Spasovski, Vesna, Anđelković, Marina, Parezanović, Marina, Komazec, Jovana, Ugrin, Milena, Klaassen, Kristel, Stojiljković, Maja, "The Role of Autophagy and Apoptosis in Affected Skin and Lungs in Patients with Systemic Sclerosis" in International Journal of Molecular Sciences, 24, no. 13 (2023):11212, https://doi.org/10.3390/ijms241311212 . .