Autologous Platelet and Extracellular Vesicle-Rich Plasma as Therapeutic Fluid: A Review
2023
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Аутори
Troha, KajaVozel, Domen
Arko, Matevž
Bedina Zavec, Apolonija
Dolinar, Drago
Hočevar, Matej
Jan, Zala
Kisovec, Matic
Kocjančič, Boštjan
Pađen, Ljubiša
Pajnič, Manca
Penič, Samo
Romolo, Anna
Repar, Neža
Spasovski, Vesna
Steiner, Nejc
Šuštar, Vid
Iglič, Aleš
Drobne, Damjana
Kogej, Ksenija
Battelino, Saba
Kralj-Iglič, Veronika
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The preparation of autologous platelet and extracellular vesicle-rich plasma (PVRP) has been explored in many medical fields with the aim to benefit from its healing potential. In parallel, efforts are being invested to understand the function and dynamics of PVRP that is complex in its composition and interactions. Some clinical evidence reveals beneficial effects of PVRP, while some report that there were no effects. To optimize the preparation methods, functions and mechanisms of PVRP, its constituents should be better understood. With the intention to promote further studies of autologous therapeutic PVRP, we performed a review on some topics regarding PVRP composition, harvesting, assessment and preservation, and also on clinical experience following PVRP application in humans and animals. Besides the acknowledged actions of platelets, leukocytes and different molecules, we focus on extracellular vesicles that were found abundant in PVRP.
Кључне речи:
centrifugation / extracellular vesicles / fresh-frozen plasma / intercellular signaling peptides and proteins / platelet-rich plasma / platelets / regeneration / small cellular particles / wound healingИзвор:
International Journal of Molecular Sciences, 2023, 24, 4, 3420-Издавач:
- MDPI
Финансирање / пројекти:
- Slovenian Research Agency P1-0201
- Slovenian Research Agency P1-0207
- Slovenian Research Agency P1-0391
- Slovenian Research Agency P2-0424
- Slovenian Research Agency P2-0132
- Slovenian Research Agency P2-0232
- Slovenian Research Agency P3-0374
- Slovenian Research Agency P3-0388
- Slovenian Research Agency J2-4447
- Slovenian Research Agency J3-3066
- Slovenian Research Agency Z1-2634
- Slovenian Research Agency J1-9162
- Slovenian Research Agency L3-2621
- National Research, Development and Innovation Office (Hungary) SNN 138407
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Troha, Kaja AU - Vozel, Domen AU - Arko, Matevž AU - Bedina Zavec, Apolonija AU - Dolinar, Drago AU - Hočevar, Matej AU - Jan, Zala AU - Kisovec, Matic AU - Kocjančič, Boštjan AU - Pađen, Ljubiša AU - Pajnič, Manca AU - Penič, Samo AU - Romolo, Anna AU - Repar, Neža AU - Spasovski, Vesna AU - Steiner, Nejc AU - Šuštar, Vid AU - Iglič, Aleš AU - Drobne, Damjana AU - Kogej, Ksenija AU - Battelino, Saba AU - Kralj-Iglič, Veronika PY - 2023 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/2087 AB - The preparation of autologous platelet and extracellular vesicle-rich plasma (PVRP) has been explored in many medical fields with the aim to benefit from its healing potential. In parallel, efforts are being invested to understand the function and dynamics of PVRP that is complex in its composition and interactions. Some clinical evidence reveals beneficial effects of PVRP, while some report that there were no effects. To optimize the preparation methods, functions and mechanisms of PVRP, its constituents should be better understood. With the intention to promote further studies of autologous therapeutic PVRP, we performed a review on some topics regarding PVRP composition, harvesting, assessment and preservation, and also on clinical experience following PVRP application in humans and animals. Besides the acknowledged actions of platelets, leukocytes and different molecules, we focus on extracellular vesicles that were found abundant in PVRP. PB - MDPI T2 - International Journal of Molecular Sciences T1 - Autologous Platelet and Extracellular Vesicle-Rich Plasma as Therapeutic Fluid: A Review IS - 4 SP - 3420 VL - 24 DO - 10.3390/ijms24043420 ER -
@article{ author = "Troha, Kaja and Vozel, Domen and Arko, Matevž and Bedina Zavec, Apolonija and Dolinar, Drago and Hočevar, Matej and Jan, Zala and Kisovec, Matic and Kocjančič, Boštjan and Pađen, Ljubiša and Pajnič, Manca and Penič, Samo and Romolo, Anna and Repar, Neža and Spasovski, Vesna and Steiner, Nejc and Šuštar, Vid and Iglič, Aleš and Drobne, Damjana and Kogej, Ksenija and Battelino, Saba and Kralj-Iglič, Veronika", year = "2023", abstract = "The preparation of autologous platelet and extracellular vesicle-rich plasma (PVRP) has been explored in many medical fields with the aim to benefit from its healing potential. In parallel, efforts are being invested to understand the function and dynamics of PVRP that is complex in its composition and interactions. Some clinical evidence reveals beneficial effects of PVRP, while some report that there were no effects. To optimize the preparation methods, functions and mechanisms of PVRP, its constituents should be better understood. With the intention to promote further studies of autologous therapeutic PVRP, we performed a review on some topics regarding PVRP composition, harvesting, assessment and preservation, and also on clinical experience following PVRP application in humans and animals. Besides the acknowledged actions of platelets, leukocytes and different molecules, we focus on extracellular vesicles that were found abundant in PVRP.", publisher = "MDPI", journal = "International Journal of Molecular Sciences", title = "Autologous Platelet and Extracellular Vesicle-Rich Plasma as Therapeutic Fluid: A Review", number = "4", pages = "3420", volume = "24", doi = "10.3390/ijms24043420" }
Troha, K., Vozel, D., Arko, M., Bedina Zavec, A., Dolinar, D., Hočevar, M., Jan, Z., Kisovec, M., Kocjančič, B., Pađen, L., Pajnič, M., Penič, S., Romolo, A., Repar, N., Spasovski, V., Steiner, N., Šuštar, V., Iglič, A., Drobne, D., Kogej, K., Battelino, S.,& Kralj-Iglič, V.. (2023). Autologous Platelet and Extracellular Vesicle-Rich Plasma as Therapeutic Fluid: A Review. in International Journal of Molecular Sciences MDPI., 24(4), 3420. https://doi.org/10.3390/ijms24043420
Troha K, Vozel D, Arko M, Bedina Zavec A, Dolinar D, Hočevar M, Jan Z, Kisovec M, Kocjančič B, Pađen L, Pajnič M, Penič S, Romolo A, Repar N, Spasovski V, Steiner N, Šuštar V, Iglič A, Drobne D, Kogej K, Battelino S, Kralj-Iglič V. Autologous Platelet and Extracellular Vesicle-Rich Plasma as Therapeutic Fluid: A Review. in International Journal of Molecular Sciences. 2023;24(4):3420. doi:10.3390/ijms24043420 .
Troha, Kaja, Vozel, Domen, Arko, Matevž, Bedina Zavec, Apolonija, Dolinar, Drago, Hočevar, Matej, Jan, Zala, Kisovec, Matic, Kocjančič, Boštjan, Pađen, Ljubiša, Pajnič, Manca, Penič, Samo, Romolo, Anna, Repar, Neža, Spasovski, Vesna, Steiner, Nejc, Šuštar, Vid, Iglič, Aleš, Drobne, Damjana, Kogej, Ksenija, Battelino, Saba, Kralj-Iglič, Veronika, "Autologous Platelet and Extracellular Vesicle-Rich Plasma as Therapeutic Fluid: A Review" in International Journal of Molecular Sciences, 24, no. 4 (2023):3420, https://doi.org/10.3390/ijms24043420 . .