SOX transcription factors – choosing between stemness and neuronal differentiation
Конференцијски прилог (Објављена верзија)
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Copyright © 2023 by Serbian Neuroscience Society and associates
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The SOX genes show properties of both classical transcription factors and
architectural components of chromatin. As a main part of regulatory networks that
consist of transcription factors, epigenetic modifiers and microRNAs, they govern
diverse cellular processes during embryonic and adult neurogenesis, such as
maintaining the multipotency of neural stem cells, cell fate decision and terminal cell
differentiation.
The sequential expression of the SoxB, SoxC, SoxD, SoxE and/or SoxF group
members in differentiating and mature neurons, oligodendrocytes and astrocytes is
essential for their identity and survival. Several studies revealed that deregulated
expression of these proteins had significant impact on the neuronal plasticity. Results
of our research using both in vivo and in vitro model systems to study neurogenesis in
different brain pathologies, demonstrated decreased expression of SOXB transcription
factor in neural stem/progenitor cells in early stages of neurodegen...eration or
following ischemia- related injury that has significant impact on regeneration
capacity. Recently, it has been demonstrated that neural stem cells from SVZ are cells
of origin of glioblastoma, the most common and devastated brain tumor. Our
investigation of SOXB showed deregulated expression of SOX3 protein also in
glioblastoma samples, compared to the expression in non-tumoral brain tissues while
exogenous overexpression of this gene promoted the malignant properties of
glioblastoma cells.
Despite numerous data implicating the key role of Sox/SOX genes in regulation
of neurogenesis, contribution of SOX genes in various brain pathologies is still not
clear. Future studies are needed to evaluate them as a potential targets in therapeutic
and regenerative strategies.
Кључне речи:
SOX genesИзвор:
8th Congress of the Serbian Neuroscience Society, 2023, 35-35Издавач:
- Belgrade : Serbian Neuroscience Society
Финансирање / пројекти:
- info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173051/RS//" (RS-MESTD-Basic Research (BR or ON)-173051)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200042 (Универзитет у Београду, Институт за молекуларну генетику и генетичко инжењерство) (RS-MESTD-inst-2020-200042)
- Serbian Academy of Arts and Sciences (F172 and F24) and Science Fund of the Republic of Serbia, Serbian Science and Diaspora Collaboration Program: Knowledge Exchange Vouchers (6436225)
Напомена:
- BOOK OF ABSTRACTS: 8th CONGRESS OF SERBIAN NEUROSCIENCE SOCIETY with international participation 31 May – 2 June 2023. Belgrade, Serbia
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - CONF AU - Švirtlih, Marija PY - 2023 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/2183 AB - The SOX genes show properties of both classical transcription factors and architectural components of chromatin. As a main part of regulatory networks that consist of transcription factors, epigenetic modifiers and microRNAs, they govern diverse cellular processes during embryonic and adult neurogenesis, such as maintaining the multipotency of neural stem cells, cell fate decision and terminal cell differentiation. The sequential expression of the SoxB, SoxC, SoxD, SoxE and/or SoxF group members in differentiating and mature neurons, oligodendrocytes and astrocytes is essential for their identity and survival. Several studies revealed that deregulated expression of these proteins had significant impact on the neuronal plasticity. Results of our research using both in vivo and in vitro model systems to study neurogenesis in different brain pathologies, demonstrated decreased expression of SOXB transcription factor in neural stem/progenitor cells in early stages of neurodegeneration or following ischemia- related injury that has significant impact on regeneration capacity. Recently, it has been demonstrated that neural stem cells from SVZ are cells of origin of glioblastoma, the most common and devastated brain tumor. Our investigation of SOXB showed deregulated expression of SOX3 protein also in glioblastoma samples, compared to the expression in non-tumoral brain tissues while exogenous overexpression of this gene promoted the malignant properties of glioblastoma cells. Despite numerous data implicating the key role of Sox/SOX genes in regulation of neurogenesis, contribution of SOX genes in various brain pathologies is still not clear. Future studies are needed to evaluate them as a potential targets in therapeutic and regenerative strategies. PB - Belgrade : Serbian Neuroscience Society C3 - 8th Congress of the Serbian Neuroscience Society T1 - SOX transcription factors – choosing between stemness and neuronal differentiation EP - 35 SP - 35 UR - https://hdl.handle.net/21.15107/rcub_imagine_2183 ER -
@conference{ author = "Švirtlih, Marija", year = "2023", abstract = "The SOX genes show properties of both classical transcription factors and architectural components of chromatin. As a main part of regulatory networks that consist of transcription factors, epigenetic modifiers and microRNAs, they govern diverse cellular processes during embryonic and adult neurogenesis, such as maintaining the multipotency of neural stem cells, cell fate decision and terminal cell differentiation. The sequential expression of the SoxB, SoxC, SoxD, SoxE and/or SoxF group members in differentiating and mature neurons, oligodendrocytes and astrocytes is essential for their identity and survival. Several studies revealed that deregulated expression of these proteins had significant impact on the neuronal plasticity. Results of our research using both in vivo and in vitro model systems to study neurogenesis in different brain pathologies, demonstrated decreased expression of SOXB transcription factor in neural stem/progenitor cells in early stages of neurodegeneration or following ischemia- related injury that has significant impact on regeneration capacity. Recently, it has been demonstrated that neural stem cells from SVZ are cells of origin of glioblastoma, the most common and devastated brain tumor. Our investigation of SOXB showed deregulated expression of SOX3 protein also in glioblastoma samples, compared to the expression in non-tumoral brain tissues while exogenous overexpression of this gene promoted the malignant properties of glioblastoma cells. Despite numerous data implicating the key role of Sox/SOX genes in regulation of neurogenesis, contribution of SOX genes in various brain pathologies is still not clear. Future studies are needed to evaluate them as a potential targets in therapeutic and regenerative strategies.", publisher = "Belgrade : Serbian Neuroscience Society", journal = "8th Congress of the Serbian Neuroscience Society", title = "SOX transcription factors – choosing between stemness and neuronal differentiation", pages = "35-35", url = "https://hdl.handle.net/21.15107/rcub_imagine_2183" }
Švirtlih, M.. (2023). SOX transcription factors – choosing between stemness and neuronal differentiation. in 8th Congress of the Serbian Neuroscience Society Belgrade : Serbian Neuroscience Society., 35-35. https://hdl.handle.net/21.15107/rcub_imagine_2183
Švirtlih M. SOX transcription factors – choosing between stemness and neuronal differentiation. in 8th Congress of the Serbian Neuroscience Society. 2023;:35-35. https://hdl.handle.net/21.15107/rcub_imagine_2183 .
Švirtlih, Marija, "SOX transcription factors – choosing between stemness and neuronal differentiation" in 8th Congress of the Serbian Neuroscience Society (2023):35-35, https://hdl.handle.net/21.15107/rcub_imagine_2183 .