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Novel target genes of PsrA transcriptional regulator of Pseudomonas aeruginosa
dc.creator | Kojić, Milan | |
dc.creator | Jovčić, Branko | |
dc.creator | Vindigni, A | |
dc.creator | Odreman, F | |
dc.creator | Venturi, V | |
dc.date.accessioned | 2022-11-15T13:41:15Z | |
dc.date.available | 2022-11-15T13:41:15Z | |
dc.date.issued | 2005 | |
dc.identifier.issn | 0378-1097 | |
dc.identifier.uri | https://imagine.imgge.bg.ac.rs/handle/123456789/225 | |
dc.description.abstract | The PsrA transcriptional regulator is involved in stationary phase induced transcriptional regulation of rpoS and in negative auto-regulation in Pseudomonas aeruginosa. This study was designed to determine whether other loci were regulated by PsrA in P. aeruginosa. Computer search was performed of the PsrA binding motif (G/CAAAC N2-4 GTTTG/C) against the P. aeruginosa genome sequence. Four of 14 analysed promoters responded to and bound PsrA; (i) divergent promoters controlling PA2952/ PA2951 and PA2953, (ii) promoter of PA0506 and (iii) upstream region of PA3571. Promoters PA0506 and PA2952-PA2951 were regulated negatively whereas promoters of PA2953 and PA3571 were regulated positively by PsrA. Two dimensional sodium dodecyl sulphate polyacrylamide gel electrophoresis (21) SDS-PAGE) analysis on total proteins from P. aeruginosa PAO1 and psrA knock-out derivative was also performed resulting in the identification of 11 protein spots which were differentially regulated. These studies have indicated PsrA as a global regulator. | en |
dc.publisher | Wiley-Blackwell, Hoboken | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | FEMS Microbiology Letters | |
dc.subject | stationary phase | en |
dc.subject | PsrA regulon | en |
dc.title | Novel target genes of PsrA transcriptional regulator of Pseudomonas aeruginosa | en |
dc.type | article | |
dc.rights.license | BY | |
dc.citation.epage | 181 | |
dc.citation.issue | 2 | |
dc.citation.other | 246(2): 175-181 | |
dc.citation.rank | M23 | |
dc.citation.spage | 175 | |
dc.citation.volume | 246 | |
dc.identifier.doi | 10.1016/j.femsle.2005.04.003 | |
dc.identifier.fulltext | https://imagine.imgge.bg.ac.rs/bitstream/id/204/222.pdf | |
dc.identifier.pmid | 15899403 | |
dc.identifier.scopus | 2-s2.0-19444366672 | |
dc.identifier.wos | 000229513800004 | |
dc.type.version | publishedVersion |