Primena filtera vene kave u terapiji dubokih venskih tromboza povezanih sa deficitom proteina S - prikaz dva slučaja
Vena caval filters placement for deep vein thrombosis caused by protein S deficiency: Two case reports
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2005
Authors
Šerbić, OliveraCijan, V.
Kekić, Z.
Šuput-Tomaš, Lj.
Paunović, M.
Janković-Oreščanin, B.
Rakićević, Ljiljana
Article (Published version)
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Prikazujemo dve mlade bolesnice (25 i 28 godina) koje su imale ponovljene tromboze dubokih vena donjih ekstremiteta. Za nastanak tromboza postojali su riziko faktori: postpartalni period, gojaznost, pušenje, septično stanje. Nove tromboze su nastale u toku adekvatne oralne antikoagulantne terapije. Kod bolesnice nakon tromboze vene kave inferior u sklopu terapije vitalno ugrožavajuće tromboze uz heparinsku i.v. terapiju plasiran je filter vene kave, kod druge je filter vene kave plasiran preventivno. Nakon kliničkog poboljšanja i prevođenja bolesnica sa visokomolekularnog na niskomolekularni heparin izvršeno je testiranje trombofilija. Kod obe je pronađen deficit proteina S, koji je utvrđen i ponovljenim testiranjem. Genetskim ispitivanjima pronađeno je da je jedna bolesnica nosilac mutacije gena za MTHFR C677T, a druga mutacije gena za protrombin G20210A (heterozigot).
Two young patients (25 and 28 years old) are presented in our article. They had lower limb deep recurrent venous thrombosis. Precipitating factors for thomboses were: puerperal period, obesity, cigarette smoking, sepsis, etc. New thrombosis occurred despite adequate oral anticoagulant therapy. The vena caval filter was inserted in the patient with thrombosis of the inferior vena cava, together with heparin i.v. therapy. It was a therapy for life threatening thrombosis. Second patient was inserted vena caval filter prophylactic. After clinic improvement low-molecular-weight heparin was administered insted of HMW heparin and tests for thrombophilia were done. Both patients had reduced protein S, which was also reduced in repeated tests. According to genetic engineering research one female patient was a carrier of mutation gene for A4THFR C677Tand the other for mutation for prothrombin G20210A.
Keywords:
tromboza / protrombin G20210A / protein S / MTHFR / filter vene kave / vena caval filter / Thrombosis / prothrombin G20210A / protein S / MTHFRSource:
Bilten za transfuziologiju, 2005, 51, 1-2, 51-55Publisher:
- Institut za transfuziju krvi Srbije, Beograd
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Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Šerbić, Olivera AU - Cijan, V. AU - Kekić, Z. AU - Šuput-Tomaš, Lj. AU - Paunović, M. AU - Janković-Oreščanin, B. AU - Rakićević, Ljiljana PY - 2005 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/230 AB - Prikazujemo dve mlade bolesnice (25 i 28 godina) koje su imale ponovljene tromboze dubokih vena donjih ekstremiteta. Za nastanak tromboza postojali su riziko faktori: postpartalni period, gojaznost, pušenje, septično stanje. Nove tromboze su nastale u toku adekvatne oralne antikoagulantne terapije. Kod bolesnice nakon tromboze vene kave inferior u sklopu terapije vitalno ugrožavajuće tromboze uz heparinsku i.v. terapiju plasiran je filter vene kave, kod druge je filter vene kave plasiran preventivno. Nakon kliničkog poboljšanja i prevođenja bolesnica sa visokomolekularnog na niskomolekularni heparin izvršeno je testiranje trombofilija. Kod obe je pronađen deficit proteina S, koji je utvrđen i ponovljenim testiranjem. Genetskim ispitivanjima pronađeno je da je jedna bolesnica nosilac mutacije gena za MTHFR C677T, a druga mutacije gena za protrombin G20210A (heterozigot). AB - Two young patients (25 and 28 years old) are presented in our article. They had lower limb deep recurrent venous thrombosis. Precipitating factors for thomboses were: puerperal period, obesity, cigarette smoking, sepsis, etc. New thrombosis occurred despite adequate oral anticoagulant therapy. The vena caval filter was inserted in the patient with thrombosis of the inferior vena cava, together with heparin i.v. therapy. It was a therapy for life threatening thrombosis. Second patient was inserted vena caval filter prophylactic. After clinic improvement low-molecular-weight heparin was administered insted of HMW heparin and tests for thrombophilia were done. Both patients had reduced protein S, which was also reduced in repeated tests. According to genetic engineering research one female patient was a carrier of mutation gene for A4THFR C677Tand the other for mutation for prothrombin G20210A. PB - Institut za transfuziju krvi Srbije, Beograd T2 - Bilten za transfuziologiju T1 - Primena filtera vene kave u terapiji dubokih venskih tromboza povezanih sa deficitom proteina S - prikaz dva slučaja T1 - Vena caval filters placement for deep vein thrombosis caused by protein S deficiency: Two case reports EP - 55 IS - 1-2 SP - 51 VL - 51 UR - https://hdl.handle.net/21.15107/rcub_imagine_230 ER -
@article{ author = "Šerbić, Olivera and Cijan, V. and Kekić, Z. and Šuput-Tomaš, Lj. and Paunović, M. and Janković-Oreščanin, B. and Rakićević, Ljiljana", year = "2005", abstract = "Prikazujemo dve mlade bolesnice (25 i 28 godina) koje su imale ponovljene tromboze dubokih vena donjih ekstremiteta. Za nastanak tromboza postojali su riziko faktori: postpartalni period, gojaznost, pušenje, septično stanje. Nove tromboze su nastale u toku adekvatne oralne antikoagulantne terapije. Kod bolesnice nakon tromboze vene kave inferior u sklopu terapije vitalno ugrožavajuće tromboze uz heparinsku i.v. terapiju plasiran je filter vene kave, kod druge je filter vene kave plasiran preventivno. Nakon kliničkog poboljšanja i prevođenja bolesnica sa visokomolekularnog na niskomolekularni heparin izvršeno je testiranje trombofilija. Kod obe je pronađen deficit proteina S, koji je utvrđen i ponovljenim testiranjem. Genetskim ispitivanjima pronađeno je da je jedna bolesnica nosilac mutacije gena za MTHFR C677T, a druga mutacije gena za protrombin G20210A (heterozigot)., Two young patients (25 and 28 years old) are presented in our article. They had lower limb deep recurrent venous thrombosis. Precipitating factors for thomboses were: puerperal period, obesity, cigarette smoking, sepsis, etc. New thrombosis occurred despite adequate oral anticoagulant therapy. The vena caval filter was inserted in the patient with thrombosis of the inferior vena cava, together with heparin i.v. therapy. It was a therapy for life threatening thrombosis. Second patient was inserted vena caval filter prophylactic. After clinic improvement low-molecular-weight heparin was administered insted of HMW heparin and tests for thrombophilia were done. Both patients had reduced protein S, which was also reduced in repeated tests. According to genetic engineering research one female patient was a carrier of mutation gene for A4THFR C677Tand the other for mutation for prothrombin G20210A.", publisher = "Institut za transfuziju krvi Srbije, Beograd", journal = "Bilten za transfuziologiju", title = "Primena filtera vene kave u terapiji dubokih venskih tromboza povezanih sa deficitom proteina S - prikaz dva slučaja, Vena caval filters placement for deep vein thrombosis caused by protein S deficiency: Two case reports", pages = "55-51", number = "1-2", volume = "51", url = "https://hdl.handle.net/21.15107/rcub_imagine_230" }
Šerbić, O., Cijan, V., Kekić, Z., Šuput-Tomaš, Lj., Paunović, M., Janković-Oreščanin, B.,& Rakićević, L.. (2005). Primena filtera vene kave u terapiji dubokih venskih tromboza povezanih sa deficitom proteina S - prikaz dva slučaja. in Bilten za transfuziologiju Institut za transfuziju krvi Srbije, Beograd., 51(1-2), 51-55. https://hdl.handle.net/21.15107/rcub_imagine_230
Šerbić O, Cijan V, Kekić Z, Šuput-Tomaš L, Paunović M, Janković-Oreščanin B, Rakićević L. Primena filtera vene kave u terapiji dubokih venskih tromboza povezanih sa deficitom proteina S - prikaz dva slučaja. in Bilten za transfuziologiju. 2005;51(1-2):51-55. https://hdl.handle.net/21.15107/rcub_imagine_230 .
Šerbić, Olivera, Cijan, V., Kekić, Z., Šuput-Tomaš, Lj., Paunović, M., Janković-Oreščanin, B., Rakićević, Ljiljana, "Primena filtera vene kave u terapiji dubokih venskih tromboza povezanih sa deficitom proteina S - prikaz dva slučaja" in Bilten za transfuziologiju, 51, no. 1-2 (2005):51-55, https://hdl.handle.net/21.15107/rcub_imagine_230 .