Exploring zebrafish swim bladder as a model for chronic lung diseases
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This project aims to identify transgenic zebrafish lines within the Kawakami Laboratory collection,
exhibiting Gal4 expression patterns in the swim bladder, to establish a robust model for investigating
the impacts of e-cigarettes. The swim bladder, sharing an embryonic background with the mammalian
lung, serves as a pertinent model due to the expression of genes crucial for lung function in adult
zebrafish. Key signaling pathways involved in human lung development, including the Sonic Hedgehog
and Wnt/β-catenin pathways, play pivotal roles in zebrafish swim bladder development. The zebrafish
swim bladder features a monolayer of cells, supported by a basement membrane. Surface surfactant is
present, while beneath the membrane, connective tissues house collagen, elastin, immune cells, and a
layer of smooth muscle cells. The research seeks zebrafish lines expressing Gal4 throughout the entire
swim bladder and, ideally, within specific cell types or layers of the swim bladder. Th...e overarching
objective of this project is to unravel the mechanistic pathways activated by e-cigarettes, potentially
contributing to the onset of lung diseases later in life. By utilizing transgenic zebrafish lines with targeted
Gal4 expression in the swim bladder, this study aims to provide insights into the specific cellular and
molecular responses induced by e-cigarette exposure, contributing valuable knowledge to the
understanding of lung disease development.
Кључне речи:
zebrafish / chronic lung diseases / e-cigaretteИзвор:
National Institute of Genetics, Mishima, Japan, 2023Финансирање / пројекти:
- NIG-JOINT, 212023
Напомена:
- Principal Investigator: Dr Aleksandra Divac Rankov, IMGGE
- Duration period: 2023-2024
Колекције
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - GEN PY - 2023 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/2305 AB - This project aims to identify transgenic zebrafish lines within the Kawakami Laboratory collection, exhibiting Gal4 expression patterns in the swim bladder, to establish a robust model for investigating the impacts of e-cigarettes. The swim bladder, sharing an embryonic background with the mammalian lung, serves as a pertinent model due to the expression of genes crucial for lung function in adult zebrafish. Key signaling pathways involved in human lung development, including the Sonic Hedgehog and Wnt/β-catenin pathways, play pivotal roles in zebrafish swim bladder development. The zebrafish swim bladder features a monolayer of cells, supported by a basement membrane. Surface surfactant is present, while beneath the membrane, connective tissues house collagen, elastin, immune cells, and a layer of smooth muscle cells. The research seeks zebrafish lines expressing Gal4 throughout the entire swim bladder and, ideally, within specific cell types or layers of the swim bladder. The overarching objective of this project is to unravel the mechanistic pathways activated by e-cigarettes, potentially contributing to the onset of lung diseases later in life. By utilizing transgenic zebrafish lines with targeted Gal4 expression in the swim bladder, this study aims to provide insights into the specific cellular and molecular responses induced by e-cigarette exposure, contributing valuable knowledge to the understanding of lung disease development. T2 - National Institute of Genetics, Mishima, Japan T1 - Exploring zebrafish swim bladder as a model for chronic lung diseases UR - https://hdl.handle.net/21.15107/rcub_imagine_2305 ER -
@misc{ year = "2023", abstract = "This project aims to identify transgenic zebrafish lines within the Kawakami Laboratory collection, exhibiting Gal4 expression patterns in the swim bladder, to establish a robust model for investigating the impacts of e-cigarettes. The swim bladder, sharing an embryonic background with the mammalian lung, serves as a pertinent model due to the expression of genes crucial for lung function in adult zebrafish. Key signaling pathways involved in human lung development, including the Sonic Hedgehog and Wnt/β-catenin pathways, play pivotal roles in zebrafish swim bladder development. The zebrafish swim bladder features a monolayer of cells, supported by a basement membrane. Surface surfactant is present, while beneath the membrane, connective tissues house collagen, elastin, immune cells, and a layer of smooth muscle cells. The research seeks zebrafish lines expressing Gal4 throughout the entire swim bladder and, ideally, within specific cell types or layers of the swim bladder. The overarching objective of this project is to unravel the mechanistic pathways activated by e-cigarettes, potentially contributing to the onset of lung diseases later in life. By utilizing transgenic zebrafish lines with targeted Gal4 expression in the swim bladder, this study aims to provide insights into the specific cellular and molecular responses induced by e-cigarette exposure, contributing valuable knowledge to the understanding of lung disease development.", journal = "National Institute of Genetics, Mishima, Japan", title = "Exploring zebrafish swim bladder as a model for chronic lung diseases", url = "https://hdl.handle.net/21.15107/rcub_imagine_2305" }
(2023). Exploring zebrafish swim bladder as a model for chronic lung diseases. in National Institute of Genetics, Mishima, Japan. https://hdl.handle.net/21.15107/rcub_imagine_2305
Exploring zebrafish swim bladder as a model for chronic lung diseases. in National Institute of Genetics, Mishima, Japan. 2023;. https://hdl.handle.net/21.15107/rcub_imagine_2305 .
"Exploring zebrafish swim bladder as a model for chronic lung diseases" in National Institute of Genetics, Mishima, Japan (2023), https://hdl.handle.net/21.15107/rcub_imagine_2305 .