Worm Profiler: Surveillance and population genetics of Echinococcus in Serbia (WORM_PROFILER)
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Метаподаци
Приказ свих података о документуАпстракт
Echinococcus, tapeworms of the Taeniidae family, can infect humans and animals and cause
serious, even lethal disease. Global population genetics data suggests that disease presentation,
severity, immune response, as well as relative host susceptibility and resistance to infection
depend on the species, genotype and haplotype. The species of significant clinical relevance in
Europe are E. granulosus, the causative agent of cystic echinococcosis (CE) and E. multilocularis,
which causes the most severe disease, alveolar echinococcosis (AE). Analysis of the population
genetics of Echinococcus is an ongoing effort in some parts of Europe, while the Balkans
represent a significant knowledge gap. This project aims to comprehensively survey the entire
transmission cycle consisting of intermediate and definitive animal hosts and the environment
using sample processing and analytical methods which have been standardized, validated and
harmonized at the EU level to obtain high quality ...population genetics data via mitochondrial gene
(cox1 and nad1) sequencing and characterization of the EmsB microsatellite from single eggs,
worms and protoscolices. As a main novelty, comprehensive Echinococcus population genetics
data, through a survey of underexplored reservoirs with a high transmission capacity to humans,
will be systematized and graphically displayed through an interactive bioinformatics database,
WormProfiler, with a user interface tailored to physicians and veterinarians. The impact of the
project is the translation of population genetics data to physicians and veterinarians, key
stakeholders for transmission prevention to facilitate education of the public and raise awareness
of echinococcosis. The project should provide the insight into the genetic diversity of
Echinococcus and identification of transmission foci, as well as a software supported framework
for systematic surveillance and future development of targeted transmission control actions to
reduce echinococcosis case burden.
Кључне речи:
EchinococcusИзвор:
Science Fund of the Republic of Serbia, Program PROMIS, 2024Финансирање / пројекти:
- Program PROMIS, 10841
Напомена:
- Principal Investigator: Dr. Aleksandra Uzelac, Institute for Medical Research, University of Belgrade
- Coordinator for IMGGE: Dr. Jelena Karanović
- Duration period: 2024-2025
Колекције
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - GEN PY - 2024 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/2308 AB - Echinococcus, tapeworms of the Taeniidae family, can infect humans and animals and cause serious, even lethal disease. Global population genetics data suggests that disease presentation, severity, immune response, as well as relative host susceptibility and resistance to infection depend on the species, genotype and haplotype. The species of significant clinical relevance in Europe are E. granulosus, the causative agent of cystic echinococcosis (CE) and E. multilocularis, which causes the most severe disease, alveolar echinococcosis (AE). Analysis of the population genetics of Echinococcus is an ongoing effort in some parts of Europe, while the Balkans represent a significant knowledge gap. This project aims to comprehensively survey the entire transmission cycle consisting of intermediate and definitive animal hosts and the environment using sample processing and analytical methods which have been standardized, validated and harmonized at the EU level to obtain high quality population genetics data via mitochondrial gene (cox1 and nad1) sequencing and characterization of the EmsB microsatellite from single eggs, worms and protoscolices. As a main novelty, comprehensive Echinococcus population genetics data, through a survey of underexplored reservoirs with a high transmission capacity to humans, will be systematized and graphically displayed through an interactive bioinformatics database, WormProfiler, with a user interface tailored to physicians and veterinarians. The impact of the project is the translation of population genetics data to physicians and veterinarians, key stakeholders for transmission prevention to facilitate education of the public and raise awareness of echinococcosis. The project should provide the insight into the genetic diversity of Echinococcus and identification of transmission foci, as well as a software supported framework for systematic surveillance and future development of targeted transmission control actions to reduce echinococcosis case burden. T2 - Science Fund of the Republic of Serbia, Program PROMIS T1 - Worm Profiler: Surveillance and population genetics of Echinococcus in Serbia (WORM_PROFILER) UR - https://hdl.handle.net/21.15107/rcub_imagine_2308 ER -
@misc{ year = "2024", abstract = "Echinococcus, tapeworms of the Taeniidae family, can infect humans and animals and cause serious, even lethal disease. Global population genetics data suggests that disease presentation, severity, immune response, as well as relative host susceptibility and resistance to infection depend on the species, genotype and haplotype. The species of significant clinical relevance in Europe are E. granulosus, the causative agent of cystic echinococcosis (CE) and E. multilocularis, which causes the most severe disease, alveolar echinococcosis (AE). Analysis of the population genetics of Echinococcus is an ongoing effort in some parts of Europe, while the Balkans represent a significant knowledge gap. This project aims to comprehensively survey the entire transmission cycle consisting of intermediate and definitive animal hosts and the environment using sample processing and analytical methods which have been standardized, validated and harmonized at the EU level to obtain high quality population genetics data via mitochondrial gene (cox1 and nad1) sequencing and characterization of the EmsB microsatellite from single eggs, worms and protoscolices. As a main novelty, comprehensive Echinococcus population genetics data, through a survey of underexplored reservoirs with a high transmission capacity to humans, will be systematized and graphically displayed through an interactive bioinformatics database, WormProfiler, with a user interface tailored to physicians and veterinarians. The impact of the project is the translation of population genetics data to physicians and veterinarians, key stakeholders for transmission prevention to facilitate education of the public and raise awareness of echinococcosis. The project should provide the insight into the genetic diversity of Echinococcus and identification of transmission foci, as well as a software supported framework for systematic surveillance and future development of targeted transmission control actions to reduce echinococcosis case burden.", journal = "Science Fund of the Republic of Serbia, Program PROMIS", title = "Worm Profiler: Surveillance and population genetics of Echinococcus in Serbia (WORM_PROFILER)", url = "https://hdl.handle.net/21.15107/rcub_imagine_2308" }
(2024). Worm Profiler: Surveillance and population genetics of Echinococcus in Serbia (WORM_PROFILER). in Science Fund of the Republic of Serbia, Program PROMIS. https://hdl.handle.net/21.15107/rcub_imagine_2308
Worm Profiler: Surveillance and population genetics of Echinococcus in Serbia (WORM_PROFILER). in Science Fund of the Republic of Serbia, Program PROMIS. 2024;. https://hdl.handle.net/21.15107/rcub_imagine_2308 .
"Worm Profiler: Surveillance and population genetics of Echinococcus in Serbia (WORM_PROFILER)" in Science Fund of the Republic of Serbia, Program PROMIS (2024), https://hdl.handle.net/21.15107/rcub_imagine_2308 .