Antimicrobial activity of Hyssopus officinalis L. subsp. aristatus (Godr.) Nyman (Lamiaceae) essential oils from Montenegro and Serbia
Апстракт
In this study, antimicrobial activity of essential oils extracted from the aerial flowering parts (herbs) of Hyssopus officinalis subsp. aristatus (Godr.) Nyman (Lamiaceae) collected from five different locations in Montenegro, or purchased in Serbia, were investigated. In addition, their antibacterial activity in combination with antibiotics was studied. The antimicrobial activity against selected standard bacterial and yeast strains was investigated using the broth microdilution method. Two standard antibiotics were used for comparison: the aminoglycoside antibiotic amikacin and the cephalosporin antibiotic ceftriaxone. The antimicrobial activity of the essential oil-amikacin combination was investigated using the checkerboard assay. The main components of the essential oils were 1,8-cineole, cis-pinocamphone, β-pinene and limonene in varying quantities. Most of the tested essential oils showed no significant antimicrobial activity. However, an essential oil rich in cis-pinocamp...hone showed moderate activity against both Staphylococcus aureus and Escherichia coli (MIC = 400 µg/mL). The overall effect of the essential oils and antibiotic combinations against E. coli or S. aureus ranged from additive (FICI = 0.625) to indifferent (FICI = 1.5), depending on the source of the essential oil.
Кључне речи:
Hyssopus officinalis / essential oil / antimicrobial activity / additive effectИзвор:
Lekovite Sirovine, 2024, 43, 1, 1-6Издавач:
- Institute for Medicinal Plants Research "Dr. Josif Pancic"
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200161 (Универзитет у Београду, Фармацеутски факултет) (RS-MESTD-inst-2020-200161)
URI
https://www.lekovitesirovine.rs/article/173https://imagine.imgge.bg.ac.rs/handle/123456789/2336
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Mićović, Tijana AU - Ušjak, Dušan AU - Milenković, Marina AU - Samardžić, Stevan AU - Maksimović, Zoran PY - 2024 UR - https://www.lekovitesirovine.rs/article/173 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/2336 AB - In this study, antimicrobial activity of essential oils extracted from the aerial flowering parts (herbs) of Hyssopus officinalis subsp. aristatus (Godr.) Nyman (Lamiaceae) collected from five different locations in Montenegro, or purchased in Serbia, were investigated. In addition, their antibacterial activity in combination with antibiotics was studied. The antimicrobial activity against selected standard bacterial and yeast strains was investigated using the broth microdilution method. Two standard antibiotics were used for comparison: the aminoglycoside antibiotic amikacin and the cephalosporin antibiotic ceftriaxone. The antimicrobial activity of the essential oil-amikacin combination was investigated using the checkerboard assay. The main components of the essential oils were 1,8-cineole, cis-pinocamphone, β-pinene and limonene in varying quantities. Most of the tested essential oils showed no significant antimicrobial activity. However, an essential oil rich in cis-pinocamphone showed moderate activity against both Staphylococcus aureus and Escherichia coli (MIC = 400 µg/mL). The overall effect of the essential oils and antibiotic combinations against E. coli or S. aureus ranged from additive (FICI = 0.625) to indifferent (FICI = 1.5), depending on the source of the essential oil. PB - Institute for Medicinal Plants Research "Dr. Josif Pancic" T2 - Lekovite Sirovine T1 - Antimicrobial activity of Hyssopus officinalis L. subsp. aristatus (Godr.) Nyman (Lamiaceae) essential oils from Montenegro and Serbia EP - 6 IS - 1 SP - 1 VL - 43 DO - 10.61652/leksir2343e173M ER -
@article{ author = "Mićović, Tijana and Ušjak, Dušan and Milenković, Marina and Samardžić, Stevan and Maksimović, Zoran", year = "2024", abstract = "In this study, antimicrobial activity of essential oils extracted from the aerial flowering parts (herbs) of Hyssopus officinalis subsp. aristatus (Godr.) Nyman (Lamiaceae) collected from five different locations in Montenegro, or purchased in Serbia, were investigated. In addition, their antibacterial activity in combination with antibiotics was studied. The antimicrobial activity against selected standard bacterial and yeast strains was investigated using the broth microdilution method. Two standard antibiotics were used for comparison: the aminoglycoside antibiotic amikacin and the cephalosporin antibiotic ceftriaxone. The antimicrobial activity of the essential oil-amikacin combination was investigated using the checkerboard assay. The main components of the essential oils were 1,8-cineole, cis-pinocamphone, β-pinene and limonene in varying quantities. Most of the tested essential oils showed no significant antimicrobial activity. However, an essential oil rich in cis-pinocamphone showed moderate activity against both Staphylococcus aureus and Escherichia coli (MIC = 400 µg/mL). The overall effect of the essential oils and antibiotic combinations against E. coli or S. aureus ranged from additive (FICI = 0.625) to indifferent (FICI = 1.5), depending on the source of the essential oil.", publisher = "Institute for Medicinal Plants Research "Dr. Josif Pancic"", journal = "Lekovite Sirovine", title = "Antimicrobial activity of Hyssopus officinalis L. subsp. aristatus (Godr.) Nyman (Lamiaceae) essential oils from Montenegro and Serbia", pages = "6-1", number = "1", volume = "43", doi = "10.61652/leksir2343e173M" }
Mićović, T., Ušjak, D., Milenković, M., Samardžić, S.,& Maksimović, Z.. (2024). Antimicrobial activity of Hyssopus officinalis L. subsp. aristatus (Godr.) Nyman (Lamiaceae) essential oils from Montenegro and Serbia. in Lekovite Sirovine Institute for Medicinal Plants Research "Dr. Josif Pancic"., 43(1), 1-6. https://doi.org/10.61652/leksir2343e173M
Mićović T, Ušjak D, Milenković M, Samardžić S, Maksimović Z. Antimicrobial activity of Hyssopus officinalis L. subsp. aristatus (Godr.) Nyman (Lamiaceae) essential oils from Montenegro and Serbia. in Lekovite Sirovine. 2024;43(1):1-6. doi:10.61652/leksir2343e173M .
Mićović, Tijana, Ušjak, Dušan, Milenković, Marina, Samardžić, Stevan, Maksimović, Zoran, "Antimicrobial activity of Hyssopus officinalis L. subsp. aristatus (Godr.) Nyman (Lamiaceae) essential oils from Montenegro and Serbia" in Lekovite Sirovine, 43, no. 1 (2024):1-6, https://doi.org/10.61652/leksir2343e173M . .