A novel thermostable YtnP lactonase inhibits biofilm formation and induces decomposition of preformed Pseudomonas aeruginosa biofilms
Апстракт
Biofilm-associated infections are the main cause of biomaterial implant failure today. The increasing prevalence of antibiotic-resistant pathogens often results in the only solution of implant movement, with serious consequences for patients. Recently, various antimicrobial agents have been recognized as a promising strategy to prevent biofilm formation on implant surfaces. Quorum sensing (QS) plays a central role in the control of bacterial virulence and biofilm formation. The use of quorum quenching (QQ) enzymes to target QS is therefore a promising innovative approach for the development of enzyme-based antivirulence therapeutics, which represent a potential solution to combat infections caused by multidrug-resistant pathogens. This study aimed to characterize the novel YtnP lactonase from the clinical isolate Stenotrophomonas maltophilia 6960 and to investigate its potential to combat the virulence of multidrug-resistant (MDR) Pseudomonas aeruginosa MMA83.
Кључне речи:
medical devices / Antivirulence / Stenotrophomonas maltophilia / quorum quenching / coating / implants / medical devicesИзвор:
Hemijska industrija (Chemical Industry), 2024, 78, 1S, 61-61Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200042 (Универзитет у Београду, Институт за молекуларну генетику и генетичко инжењерство) (RS-MESTD-inst-2020-200042)
URI
https://www.ache-pub.org.rs/index.php/HemInd/article/view/1308https://imagine.imgge.bg.ac.rs/handle/123456789/2359
Колекције
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - CONF AU - Ćurčić, Jovana AU - Malešević, Milka AU - Jovčić, Branko PY - 2024 UR - https://www.ache-pub.org.rs/index.php/HemInd/article/view/1308 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/2359 AB - Biofilm-associated infections are the main cause of biomaterial implant failure today. The increasing prevalence of antibiotic-resistant pathogens often results in the only solution of implant movement, with serious consequences for patients. Recently, various antimicrobial agents have been recognized as a promising strategy to prevent biofilm formation on implant surfaces. Quorum sensing (QS) plays a central role in the control of bacterial virulence and biofilm formation. The use of quorum quenching (QQ) enzymes to target QS is therefore a promising innovative approach for the development of enzyme-based antivirulence therapeutics, which represent a potential solution to combat infections caused by multidrug-resistant pathogens. This study aimed to characterize the novel YtnP lactonase from the clinical isolate Stenotrophomonas maltophilia 6960 and to investigate its potential to combat the virulence of multidrug-resistant (MDR) Pseudomonas aeruginosa MMA83. C3 - Hemijska industrija (Chemical Industry) T1 - A novel thermostable YtnP lactonase inhibits biofilm formation and induces decomposition of preformed Pseudomonas aeruginosa biofilms EP - 61 IS - 1S SP - 61 VL - 78 UR - https://hdl.handle.net/21.15107/rcub_imagine_2359 ER -
@conference{ author = "Ćurčić, Jovana and Malešević, Milka and Jovčić, Branko", year = "2024", abstract = "Biofilm-associated infections are the main cause of biomaterial implant failure today. The increasing prevalence of antibiotic-resistant pathogens often results in the only solution of implant movement, with serious consequences for patients. Recently, various antimicrobial agents have been recognized as a promising strategy to prevent biofilm formation on implant surfaces. Quorum sensing (QS) plays a central role in the control of bacterial virulence and biofilm formation. The use of quorum quenching (QQ) enzymes to target QS is therefore a promising innovative approach for the development of enzyme-based antivirulence therapeutics, which represent a potential solution to combat infections caused by multidrug-resistant pathogens. This study aimed to characterize the novel YtnP lactonase from the clinical isolate Stenotrophomonas maltophilia 6960 and to investigate its potential to combat the virulence of multidrug-resistant (MDR) Pseudomonas aeruginosa MMA83.", journal = "Hemijska industrija (Chemical Industry)", title = "A novel thermostable YtnP lactonase inhibits biofilm formation and induces decomposition of preformed Pseudomonas aeruginosa biofilms", pages = "61-61", number = "1S", volume = "78", url = "https://hdl.handle.net/21.15107/rcub_imagine_2359" }
Ćurčić, J., Malešević, M.,& Jovčić, B.. (2024). A novel thermostable YtnP lactonase inhibits biofilm formation and induces decomposition of preformed Pseudomonas aeruginosa biofilms. in Hemijska industrija (Chemical Industry), 78(1S), 61-61. https://hdl.handle.net/21.15107/rcub_imagine_2359
Ćurčić J, Malešević M, Jovčić B. A novel thermostable YtnP lactonase inhibits biofilm formation and induces decomposition of preformed Pseudomonas aeruginosa biofilms. in Hemijska industrija (Chemical Industry). 2024;78(1S):61-61. https://hdl.handle.net/21.15107/rcub_imagine_2359 .
Ćurčić, Jovana, Malešević, Milka, Jovčić, Branko, "A novel thermostable YtnP lactonase inhibits biofilm formation and induces decomposition of preformed Pseudomonas aeruginosa biofilms" in Hemijska industrija (Chemical Industry), 78, no. 1S (2024):61-61, https://hdl.handle.net/21.15107/rcub_imagine_2359 .