Biomimetic tumor engineering to enhance drug discovery - BioengineeredTumor
Аутори
Obradović, BojanaStojkovska, Jasmina
Zvicer, Jovana
Milivojević, Milena
Janković, Radmila
Dragoj, Miodrag
Jančić, Ivan
Конференцијски прилог
Метаподаци
Приказ свих података о документуАпстракт
Development of novel, effective, and safe anti-tumor drugs is still a slow and cumbersome process, which is often attributed to weaknesses of current preclinical assays and low correlation of the preclinical in vitro and in vivo data with the results obtained in clinical trials. Consequently, there is a clear need for development of more reliable in vitro three dimensional (3D) tumor models, which will capture key features of the in vivo tumor cell microenvironment and provide drug testing results relevant for human patients. The aim of the project “Biomimetic tumor engineering to enhance drug discovery – BioengineeredTumor” funded by the Science Fund of the Republic of Serbia is to develop 2 novel, simple and robust 3D models for cultures of carcinoma and osteosarcoma cells by applying systematic and integrated methodology to comprehensively define the key model components. In specific, the aim is to use different human and animal cancer cell lines in conjunction with alginate-based b...iomaterials as artificial extracellular matrices imitating tumor environments and to cultivate the obtained constructs in perfusion bioreactors providing enhanced transport of nutrients, gases and biochemical signals to the cells as well as adequate levels of hydrodynamic shear stresses. Thus, the strategic goal is to establish an adaptable platform suited to the use by scientists without technical expertise for long-term in vitro studies of cancer cells for applications in anti-cancer drug discovery and validation, development of personalized medical treatments, and cancer research.
Кључне речи:
3D cell culture / cancer / perfusion bioreactor / carcinoma / osteosarcomaИзвор:
Hemijska industrija (Chemical Industry), 2024, 78, 1S, 22-22Финансирање / пројекти:
- BioengineeredTumor - Biomimetic tumor engineering to enhance drug discovery (RS-ScienceFundRS-Prizma2023_BM-7503)
URI
https://www.ache-pub.org.rs/index.php/HemInd/article/view/1265https://imagine.imgge.bg.ac.rs/handle/123456789/2365
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - CONF AU - Obradović, Bojana AU - Stojkovska, Jasmina AU - Zvicer, Jovana AU - Milivojević, Milena AU - Janković, Radmila AU - Dragoj, Miodrag AU - Jančić, Ivan PY - 2024 UR - https://www.ache-pub.org.rs/index.php/HemInd/article/view/1265 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/2365 AB - Development of novel, effective, and safe anti-tumor drugs is still a slow and cumbersome process, which is often attributed to weaknesses of current preclinical assays and low correlation of the preclinical in vitro and in vivo data with the results obtained in clinical trials. Consequently, there is a clear need for development of more reliable in vitro three dimensional (3D) tumor models, which will capture key features of the in vivo tumor cell microenvironment and provide drug testing results relevant for human patients. The aim of the project “Biomimetic tumor engineering to enhance drug discovery – BioengineeredTumor” funded by the Science Fund of the Republic of Serbia is to develop 2 novel, simple and robust 3D models for cultures of carcinoma and osteosarcoma cells by applying systematic and integrated methodology to comprehensively define the key model components. In specific, the aim is to use different human and animal cancer cell lines in conjunction with alginate-based biomaterials as artificial extracellular matrices imitating tumor environments and to cultivate the obtained constructs in perfusion bioreactors providing enhanced transport of nutrients, gases and biochemical signals to the cells as well as adequate levels of hydrodynamic shear stresses. Thus, the strategic goal is to establish an adaptable platform suited to the use by scientists without technical expertise for long-term in vitro studies of cancer cells for applications in anti-cancer drug discovery and validation, development of personalized medical treatments, and cancer research. C3 - Hemijska industrija (Chemical Industry) T1 - Biomimetic tumor engineering to enhance drug discovery - BioengineeredTumor EP - 22 IS - 1S SP - 22 VL - 78 UR - https://hdl.handle.net/21.15107/rcub_imagine_2365 ER -
@conference{ author = "Obradović, Bojana and Stojkovska, Jasmina and Zvicer, Jovana and Milivojević, Milena and Janković, Radmila and Dragoj, Miodrag and Jančić, Ivan", year = "2024", abstract = "Development of novel, effective, and safe anti-tumor drugs is still a slow and cumbersome process, which is often attributed to weaknesses of current preclinical assays and low correlation of the preclinical in vitro and in vivo data with the results obtained in clinical trials. Consequently, there is a clear need for development of more reliable in vitro three dimensional (3D) tumor models, which will capture key features of the in vivo tumor cell microenvironment and provide drug testing results relevant for human patients. The aim of the project “Biomimetic tumor engineering to enhance drug discovery – BioengineeredTumor” funded by the Science Fund of the Republic of Serbia is to develop 2 novel, simple and robust 3D models for cultures of carcinoma and osteosarcoma cells by applying systematic and integrated methodology to comprehensively define the key model components. In specific, the aim is to use different human and animal cancer cell lines in conjunction with alginate-based biomaterials as artificial extracellular matrices imitating tumor environments and to cultivate the obtained constructs in perfusion bioreactors providing enhanced transport of nutrients, gases and biochemical signals to the cells as well as adequate levels of hydrodynamic shear stresses. Thus, the strategic goal is to establish an adaptable platform suited to the use by scientists without technical expertise for long-term in vitro studies of cancer cells for applications in anti-cancer drug discovery and validation, development of personalized medical treatments, and cancer research.", journal = "Hemijska industrija (Chemical Industry)", title = "Biomimetic tumor engineering to enhance drug discovery - BioengineeredTumor", pages = "22-22", number = "1S", volume = "78", url = "https://hdl.handle.net/21.15107/rcub_imagine_2365" }
Obradović, B., Stojkovska, J., Zvicer, J., Milivojević, M., Janković, R., Dragoj, M.,& Jančić, I.. (2024). Biomimetic tumor engineering to enhance drug discovery - BioengineeredTumor. in Hemijska industrija (Chemical Industry), 78(1S), 22-22. https://hdl.handle.net/21.15107/rcub_imagine_2365
Obradović B, Stojkovska J, Zvicer J, Milivojević M, Janković R, Dragoj M, Jančić I. Biomimetic tumor engineering to enhance drug discovery - BioengineeredTumor. in Hemijska industrija (Chemical Industry). 2024;78(1S):22-22. https://hdl.handle.net/21.15107/rcub_imagine_2365 .
Obradović, Bojana, Stojkovska, Jasmina, Zvicer, Jovana, Milivojević, Milena, Janković, Radmila, Dragoj, Miodrag, Jančić, Ivan, "Biomimetic tumor engineering to enhance drug discovery - BioengineeredTumor" in Hemijska industrija (Chemical Industry), 78, no. 1S (2024):22-22, https://hdl.handle.net/21.15107/rcub_imagine_2365 .