Doxorubicin and quercetin combined effect on SAOS-2 cells grown in 2D and 3D model systems
Authors
Bojić, LukaPejić, Jelena
Stojkovska, Jasmina
Stevanović, Milena
Medić, Aleksandra
Petrović, Isidora
Milivojević, Milena
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Osteosarcoma (OS) is a highly aggressive primary malignant bone tumor that most commonly affects children, adolescents, and young adults. The standard treatment for OS consists of surgical resection and chemotherapy, whereas radiation therapy is recommended for the unresectable tumor. Due to its easy metastasis and recurrence, the 5-year overall survival rate is only 66.5 %. Thus, there is a critical need to recognize the molecular mechanisms underlying OS development and pathogenesis. Traditionally, two-dimensional (2D) cells are widely used in cancer biology and pre-clinical studies. However, 2D models are unable to mimic cell–cell and cell-extracellular matrix interactions which are crucial for adequate cellular function. Three-dimensional (3D) model systems are able to recapitulate key features of human cancer and are recognized as a promising platform for fundamental and translational research. In the present work, we established an osteosarcoma 3D model based on alginate microbea...ds and studied the effect of combined treatment with doxorubicin (Doxo), widely used chemotherapeutic, and quercetin (Quer), a plant pigment with anticancer properties, on OS model systems.
Keywords:
Osteosarcoma / alginate microbeads / anticancer treatmentSource:
Hemijska industrija (Chemical Industry), 2024, 78, 1S, 20-20Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200042 (University of Belgrade, Institute of Molecular Genetics and Genetic Engineering) (RS-MESTD-inst-2020-200042)
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https://www.ache-pub.org.rs/index.php/HemInd/article/view/1262https://imagine.imgge.bg.ac.rs/handle/123456789/2366
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Institut za molekularnu genetiku i genetičko inženjerstvoTY - CONF AU - Bojić, Luka AU - Pejić, Jelena AU - Stojkovska, Jasmina AU - Stevanović, Milena AU - Medić, Aleksandra AU - Petrović, Isidora AU - Milivojević, Milena PY - 2024 UR - https://www.ache-pub.org.rs/index.php/HemInd/article/view/1262 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/2366 AB - Osteosarcoma (OS) is a highly aggressive primary malignant bone tumor that most commonly affects children, adolescents, and young adults. The standard treatment for OS consists of surgical resection and chemotherapy, whereas radiation therapy is recommended for the unresectable tumor. Due to its easy metastasis and recurrence, the 5-year overall survival rate is only 66.5 %. Thus, there is a critical need to recognize the molecular mechanisms underlying OS development and pathogenesis. Traditionally, two-dimensional (2D) cells are widely used in cancer biology and pre-clinical studies. However, 2D models are unable to mimic cell–cell and cell-extracellular matrix interactions which are crucial for adequate cellular function. Three-dimensional (3D) model systems are able to recapitulate key features of human cancer and are recognized as a promising platform for fundamental and translational research. In the present work, we established an osteosarcoma 3D model based on alginate microbeads and studied the effect of combined treatment with doxorubicin (Doxo), widely used chemotherapeutic, and quercetin (Quer), a plant pigment with anticancer properties, on OS model systems. C3 - Hemijska industrija (Chemical Industry) T1 - Doxorubicin and quercetin combined effect on SAOS-2 cells grown in 2D and 3D model systems EP - 20 IS - 1S SP - 20 VL - 78 UR - https://hdl.handle.net/21.15107/rcub_imagine_2366 ER -
@conference{ author = "Bojić, Luka and Pejić, Jelena and Stojkovska, Jasmina and Stevanović, Milena and Medić, Aleksandra and Petrović, Isidora and Milivojević, Milena", year = "2024", abstract = "Osteosarcoma (OS) is a highly aggressive primary malignant bone tumor that most commonly affects children, adolescents, and young adults. The standard treatment for OS consists of surgical resection and chemotherapy, whereas radiation therapy is recommended for the unresectable tumor. Due to its easy metastasis and recurrence, the 5-year overall survival rate is only 66.5 %. Thus, there is a critical need to recognize the molecular mechanisms underlying OS development and pathogenesis. Traditionally, two-dimensional (2D) cells are widely used in cancer biology and pre-clinical studies. However, 2D models are unable to mimic cell–cell and cell-extracellular matrix interactions which are crucial for adequate cellular function. Three-dimensional (3D) model systems are able to recapitulate key features of human cancer and are recognized as a promising platform for fundamental and translational research. In the present work, we established an osteosarcoma 3D model based on alginate microbeads and studied the effect of combined treatment with doxorubicin (Doxo), widely used chemotherapeutic, and quercetin (Quer), a plant pigment with anticancer properties, on OS model systems.", journal = "Hemijska industrija (Chemical Industry)", title = "Doxorubicin and quercetin combined effect on SAOS-2 cells grown in 2D and 3D model systems", pages = "20-20", number = "1S", volume = "78", url = "https://hdl.handle.net/21.15107/rcub_imagine_2366" }
Bojić, L., Pejić, J., Stojkovska, J., Stevanović, M., Medić, A., Petrović, I.,& Milivojević, M.. (2024). Doxorubicin and quercetin combined effect on SAOS-2 cells grown in 2D and 3D model systems. in Hemijska industrija (Chemical Industry), 78(1S), 20-20. https://hdl.handle.net/21.15107/rcub_imagine_2366
Bojić L, Pejić J, Stojkovska J, Stevanović M, Medić A, Petrović I, Milivojević M. Doxorubicin and quercetin combined effect on SAOS-2 cells grown in 2D and 3D model systems. in Hemijska industrija (Chemical Industry). 2024;78(1S):20-20. https://hdl.handle.net/21.15107/rcub_imagine_2366 .
Bojić, Luka, Pejić, Jelena, Stojkovska, Jasmina, Stevanović, Milena, Medić, Aleksandra, Petrović, Isidora, Milivojević, Milena, "Doxorubicin and quercetin combined effect on SAOS-2 cells grown in 2D and 3D model systems" in Hemijska industrija (Chemical Industry), 78, no. 1S (2024):20-20, https://hdl.handle.net/21.15107/rcub_imagine_2366 .