ACINETOBACTER BAUMANNII RESISTANT TO LAST-LINE ANTIBIOTICS: AN EMERGING THREAT IN THE WESTERN BALKANS
2024
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Prikaz svih podataka o dokumentuApstrakt
Acinetobacter baumannii is considered one of
the greatest threats to public health on a global
scale. This Gram-negative pathogen causes
severe infections, mostly of nosocomial origin,
with a high mortality rate. In recent years, the
rapid increase in the emergence and spread of
antibiotic resistance in A. baumannii has significantly
limited the effective therapeutic options
against infections caused by this bacterium.
The last-line antibiotics used in the treatment
of multidrug-resistant (MDR) A. baumannii
are carbapenems, tigecycline and polymyxins.
However, resistance to these antibiotics is
steadily increasing, especially to carbapenems,
leading to an extensively drug-resistant (XDR)
and even pandrug-resistant (PDR) phenotype
of A. baumannii. In 2021, the European Centre
for Disease Prevention and Control (ECDC) reported
that resistance of Acinetobacter spp. to
carbapenems reached 50% or more, mostly in
Southern and Eastern European countries. Although
the West...ern Balkans is a part of this region,
detailed studies on the epidemiology and
antibiotic resistance of A. baumannii are mainly
limited to Serbia and Croatia. In most cases, carbapenem
resistance in A. baumannii is due to
the production of carbapenemases, in particular
b-lactamases belonging to the class D known
as oxacillinases. The studies from the Western
Balkan countries revealed that besides the intrinsic
blaOXA-51-like gene, the most prevalent
acquired oxacillinase gene was the blaOXA-
24-like followed by the blaOXA-23-like, while
the blaOXA-58-like and metallo- b-lactamase
blaNDM-1 genes were less common. Although
significantly lower compared to carbapenem-resistant,
the number of A. baumannii isolates resistant
to tigecycline and colistin is on a continual
rise in the Western Balkans. As worldwide,
the main mechanism conferring tigecycline resistance
to A. baumannii from the Western Balkans
was overexpression of efflux pumps. Also,
the majority of reported alternations leading to
colistin resistance in A. baumannii were found in
the pmrCAB operon, which is responsible for the
modification of the colistin target, LPS.
Ključne reči:
Acinetobacter baumannii / antibiotic resistance / carbapenems / tigecycline / colistinIzvor:
XIII Congress of microbiologists of Serbia: From biotechnology to human and planetary health, 2024, 174-174Izdavač:
- Serbian Society for Microbiology
Finansiranje / projekti:
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200042 (Univerzitet u Beogradu, Institut za molekularnu genetiku i genetičko inženjerstvo) (RS-MESTD-inst-2020-200042)
Napomena:
- Book of abstract: From biotechnology to human and planetary health XIII congress of microbiologists of Serbia with international participation Mikromed regio 5, ums series 24: 4th – 6th april 2024, Mona Plaza hotel, Belgrade, Serbia
Kolekcije
Institucija/grupa
Institut za molekularnu genetiku i genetičko inženjerstvoTY - CONF AU - Novović, Katarina AU - Jovčić, Branko PY - 2024 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/2385 AB - Acinetobacter baumannii is considered one of the greatest threats to public health on a global scale. This Gram-negative pathogen causes severe infections, mostly of nosocomial origin, with a high mortality rate. In recent years, the rapid increase in the emergence and spread of antibiotic resistance in A. baumannii has significantly limited the effective therapeutic options against infections caused by this bacterium. The last-line antibiotics used in the treatment of multidrug-resistant (MDR) A. baumannii are carbapenems, tigecycline and polymyxins. However, resistance to these antibiotics is steadily increasing, especially to carbapenems, leading to an extensively drug-resistant (XDR) and even pandrug-resistant (PDR) phenotype of A. baumannii. In 2021, the European Centre for Disease Prevention and Control (ECDC) reported that resistance of Acinetobacter spp. to carbapenems reached 50% or more, mostly in Southern and Eastern European countries. Although the Western Balkans is a part of this region, detailed studies on the epidemiology and antibiotic resistance of A. baumannii are mainly limited to Serbia and Croatia. In most cases, carbapenem resistance in A. baumannii is due to the production of carbapenemases, in particular b-lactamases belonging to the class D known as oxacillinases. The studies from the Western Balkan countries revealed that besides the intrinsic blaOXA-51-like gene, the most prevalent acquired oxacillinase gene was the blaOXA- 24-like followed by the blaOXA-23-like, while the blaOXA-58-like and metallo- b-lactamase blaNDM-1 genes were less common. Although significantly lower compared to carbapenem-resistant, the number of A. baumannii isolates resistant to tigecycline and colistin is on a continual rise in the Western Balkans. As worldwide, the main mechanism conferring tigecycline resistance to A. baumannii from the Western Balkans was overexpression of efflux pumps. Also, the majority of reported alternations leading to colistin resistance in A. baumannii were found in the pmrCAB operon, which is responsible for the modification of the colistin target, LPS. PB - Serbian Society for Microbiology C3 - XIII Congress of microbiologists of Serbia: From biotechnology to human and planetary health T1 - ACINETOBACTER BAUMANNII RESISTANT TO LAST-LINE ANTIBIOTICS: AN EMERGING THREAT IN THE WESTERN BALKANS EP - 174 SP - 174 UR - https://hdl.handle.net/21.15107/rcub_imagine_2385 ER -
@conference{ author = "Novović, Katarina and Jovčić, Branko", year = "2024", abstract = "Acinetobacter baumannii is considered one of the greatest threats to public health on a global scale. This Gram-negative pathogen causes severe infections, mostly of nosocomial origin, with a high mortality rate. In recent years, the rapid increase in the emergence and spread of antibiotic resistance in A. baumannii has significantly limited the effective therapeutic options against infections caused by this bacterium. The last-line antibiotics used in the treatment of multidrug-resistant (MDR) A. baumannii are carbapenems, tigecycline and polymyxins. However, resistance to these antibiotics is steadily increasing, especially to carbapenems, leading to an extensively drug-resistant (XDR) and even pandrug-resistant (PDR) phenotype of A. baumannii. In 2021, the European Centre for Disease Prevention and Control (ECDC) reported that resistance of Acinetobacter spp. to carbapenems reached 50% or more, mostly in Southern and Eastern European countries. Although the Western Balkans is a part of this region, detailed studies on the epidemiology and antibiotic resistance of A. baumannii are mainly limited to Serbia and Croatia. In most cases, carbapenem resistance in A. baumannii is due to the production of carbapenemases, in particular b-lactamases belonging to the class D known as oxacillinases. The studies from the Western Balkan countries revealed that besides the intrinsic blaOXA-51-like gene, the most prevalent acquired oxacillinase gene was the blaOXA- 24-like followed by the blaOXA-23-like, while the blaOXA-58-like and metallo- b-lactamase blaNDM-1 genes were less common. Although significantly lower compared to carbapenem-resistant, the number of A. baumannii isolates resistant to tigecycline and colistin is on a continual rise in the Western Balkans. As worldwide, the main mechanism conferring tigecycline resistance to A. baumannii from the Western Balkans was overexpression of efflux pumps. Also, the majority of reported alternations leading to colistin resistance in A. baumannii were found in the pmrCAB operon, which is responsible for the modification of the colistin target, LPS.", publisher = "Serbian Society for Microbiology", journal = "XIII Congress of microbiologists of Serbia: From biotechnology to human and planetary health", title = "ACINETOBACTER BAUMANNII RESISTANT TO LAST-LINE ANTIBIOTICS: AN EMERGING THREAT IN THE WESTERN BALKANS", pages = "174-174", url = "https://hdl.handle.net/21.15107/rcub_imagine_2385" }
Novović, K.,& Jovčić, B.. (2024). ACINETOBACTER BAUMANNII RESISTANT TO LAST-LINE ANTIBIOTICS: AN EMERGING THREAT IN THE WESTERN BALKANS. in XIII Congress of microbiologists of Serbia: From biotechnology to human and planetary health Serbian Society for Microbiology., 174-174. https://hdl.handle.net/21.15107/rcub_imagine_2385
Novović K, Jovčić B. ACINETOBACTER BAUMANNII RESISTANT TO LAST-LINE ANTIBIOTICS: AN EMERGING THREAT IN THE WESTERN BALKANS. in XIII Congress of microbiologists of Serbia: From biotechnology to human and planetary health. 2024;:174-174. https://hdl.handle.net/21.15107/rcub_imagine_2385 .
Novović, Katarina, Jovčić, Branko, "ACINETOBACTER BAUMANNII RESISTANT TO LAST-LINE ANTIBIOTICS: AN EMERGING THREAT IN THE WESTERN BALKANS" in XIII Congress of microbiologists of Serbia: From biotechnology to human and planetary health (2024):174-174, https://hdl.handle.net/21.15107/rcub_imagine_2385 .