Unveiling the Roles of Cysteine Proteinases F and W: From Structure to Pathological Implications and Therapeutic Targets
Authors
Zdravkova, KristinaMijanović, Olja
Branković, Ana
Ilicheva, Polina M.
Jakovleva, Aleksandra
Karanović, Jelena
Pualić, Milena
Pualić, Dusan
Rubel, Aleksandr A.
Savvateeva, Lyudmila V.
Parodi, Alessandro
Zamyatnin, Andrey A.
Article (Published version)
Metadata
Show full item recordAbstract
Cysteine cathepsins F and W are members of the papain-like cysteine protease family, which have distinct structural features and functional roles in various physiological and pathological processes. This review provides a comprehensive overview of the current understanding of the structure, biological functions, and pathological implications of cathepsins F and W. Beginning with an introduction to these proteases, we delve into their structural characteristics and elucidate their unique features that dictate their enzymatic activities and substrate specificity. We also explore the intricate involvement of cathepsins F and W in malignancies, highlighting their role as potential biomarkers and therapeutic targets in cancer progression. Furthermore, we discuss the emerging roles of these enzymes in immune response modulation and neurological disorders, shedding light on their implications in autoimmune and neurodegenerative diseases. Finally, we review the landscape of inhibitors targetin...g these proteases, highlighting their therapeutic potential and challenges in clinical translation. This review brings together the diverse facets of cysteine cathepsins F and W, providing insights into their roles in health and disease and guiding future investigations for therapeutic advances.
Keywords:
cysteine cathepsins / inhibitors / pathology / therapySource:
Cells, 2024, 13, 11, 917-Publisher:
- MDPI
Collections
Institution/Community
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Zdravkova, Kristina AU - Mijanović, Olja AU - Branković, Ana AU - Ilicheva, Polina M. AU - Jakovleva, Aleksandra AU - Karanović, Jelena AU - Pualić, Milena AU - Pualić, Dusan AU - Rubel, Aleksandr A. AU - Savvateeva, Lyudmila V. AU - Parodi, Alessandro AU - Zamyatnin, Andrey A. PY - 2024 UR - https://www.mdpi.com/2073-4409/13/11/917 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/2395 AB - Cysteine cathepsins F and W are members of the papain-like cysteine protease family, which have distinct structural features and functional roles in various physiological and pathological processes. This review provides a comprehensive overview of the current understanding of the structure, biological functions, and pathological implications of cathepsins F and W. Beginning with an introduction to these proteases, we delve into their structural characteristics and elucidate their unique features that dictate their enzymatic activities and substrate specificity. We also explore the intricate involvement of cathepsins F and W in malignancies, highlighting their role as potential biomarkers and therapeutic targets in cancer progression. Furthermore, we discuss the emerging roles of these enzymes in immune response modulation and neurological disorders, shedding light on their implications in autoimmune and neurodegenerative diseases. Finally, we review the landscape of inhibitors targeting these proteases, highlighting their therapeutic potential and challenges in clinical translation. This review brings together the diverse facets of cysteine cathepsins F and W, providing insights into their roles in health and disease and guiding future investigations for therapeutic advances. PB - MDPI T2 - Cells T1 - Unveiling the Roles of Cysteine Proteinases F and W: From Structure to Pathological Implications and Therapeutic Targets IS - 11 SP - 917 VL - 13 DO - 10.3390/cells13110917 ER -
@article{ author = "Zdravkova, Kristina and Mijanović, Olja and Branković, Ana and Ilicheva, Polina M. and Jakovleva, Aleksandra and Karanović, Jelena and Pualić, Milena and Pualić, Dusan and Rubel, Aleksandr A. and Savvateeva, Lyudmila V. and Parodi, Alessandro and Zamyatnin, Andrey A.", year = "2024", abstract = "Cysteine cathepsins F and W are members of the papain-like cysteine protease family, which have distinct structural features and functional roles in various physiological and pathological processes. This review provides a comprehensive overview of the current understanding of the structure, biological functions, and pathological implications of cathepsins F and W. Beginning with an introduction to these proteases, we delve into their structural characteristics and elucidate their unique features that dictate their enzymatic activities and substrate specificity. We also explore the intricate involvement of cathepsins F and W in malignancies, highlighting their role as potential biomarkers and therapeutic targets in cancer progression. Furthermore, we discuss the emerging roles of these enzymes in immune response modulation and neurological disorders, shedding light on their implications in autoimmune and neurodegenerative diseases. Finally, we review the landscape of inhibitors targeting these proteases, highlighting their therapeutic potential and challenges in clinical translation. This review brings together the diverse facets of cysteine cathepsins F and W, providing insights into their roles in health and disease and guiding future investigations for therapeutic advances.", publisher = "MDPI", journal = "Cells", title = "Unveiling the Roles of Cysteine Proteinases F and W: From Structure to Pathological Implications and Therapeutic Targets", number = "11", pages = "917", volume = "13", doi = "10.3390/cells13110917" }
Zdravkova, K., Mijanović, O., Branković, A., Ilicheva, P. M., Jakovleva, A., Karanović, J., Pualić, M., Pualić, D., Rubel, A. A., Savvateeva, L. V., Parodi, A.,& Zamyatnin, A. A.. (2024). Unveiling the Roles of Cysteine Proteinases F and W: From Structure to Pathological Implications and Therapeutic Targets. in Cells MDPI., 13(11), 917. https://doi.org/10.3390/cells13110917
Zdravkova K, Mijanović O, Branković A, Ilicheva PM, Jakovleva A, Karanović J, Pualić M, Pualić D, Rubel AA, Savvateeva LV, Parodi A, Zamyatnin AA. Unveiling the Roles of Cysteine Proteinases F and W: From Structure to Pathological Implications and Therapeutic Targets. in Cells. 2024;13(11):917. doi:10.3390/cells13110917 .
Zdravkova, Kristina, Mijanović, Olja, Branković, Ana, Ilicheva, Polina M., Jakovleva, Aleksandra, Karanović, Jelena, Pualić, Milena, Pualić, Dusan, Rubel, Aleksandr A., Savvateeva, Lyudmila V., Parodi, Alessandro, Zamyatnin, Andrey A., "Unveiling the Roles of Cysteine Proteinases F and W: From Structure to Pathological Implications and Therapeutic Targets" in Cells, 13, no. 11 (2024):917, https://doi.org/10.3390/cells13110917 . .