GAD isoforms exhibit distinct spatiotemporal expression patterns in the developing mouse lens: Correlation with Dlx2 and Dlx5
Само за регистроване кориснике
2007
Аутори
Kwakowsky, Andrea![](/themes/Mirageimagine/images/orcid.png)
Schwirtlich, Marija
![](/themes/Mirageimagine/images/orcid.png)
Zhang, Qi
Eisenstat, David D.
Erdelyi, Ferenc
Baranyi, Maria
Katarova, Zoya D.
Szabo, Gabor
![](/themes/Mirageimagine/images/orcid.png)
Чланак у часопису (Објављена верзија)
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Метаподаци
Приказ свих података о документуАпстракт
Gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter of the adult nervous system and its biosynthetic enzyme glutamic acid.. decarboxylase (GAD) are abundantly expressed in the embryonic nervous system and are involved in the modulation of cell proliferation, migration, and differentiation. Here we describe for the first time the expression of GABA and embryonic and adult GAD isoforms in the developing mouse lens. We show that the GAD isoforms are sequentially induced with specific spatiotemporal profiles: GAD65 and embryonic GAD isoforms prevail in primary fibers, while GAD67 is the predominant GAD expressed in the postnatal secondary fibers. This pattern correlates well with the expression of Dlx2 and Dlx5, known as upstream regulators of GAD. GABA and GAD are most abundant at the tips of elongating fibers and are absent from organelle-free cells, suggesting their involvement is primarily in shaping of the cytoskeleton during fiber elongation stages.
Кључне речи:
Prox1 / lens fiber cells / GAD67 / GAD65 / GAD65/gfp transgenic mice / GABA / embryonic GAD / DlxИзвор:
Developmental Dynamics, 2007, 236, 12, 3532-3544Издавач:
- Wiley-Liss, Hoboken
DOI: 10.1002/dvdy.21361
ISSN: 1058-8388
PubMed: 17969168
WoS: 000251780300032
Scopus: 2-s2.0-37249028599
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Kwakowsky, Andrea AU - Schwirtlich, Marija AU - Zhang, Qi AU - Eisenstat, David D. AU - Erdelyi, Ferenc AU - Baranyi, Maria AU - Katarova, Zoya D. AU - Szabo, Gabor PY - 2007 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/279 AB - Gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter of the adult nervous system and its biosynthetic enzyme glutamic acid.. decarboxylase (GAD) are abundantly expressed in the embryonic nervous system and are involved in the modulation of cell proliferation, migration, and differentiation. Here we describe for the first time the expression of GABA and embryonic and adult GAD isoforms in the developing mouse lens. We show that the GAD isoforms are sequentially induced with specific spatiotemporal profiles: GAD65 and embryonic GAD isoforms prevail in primary fibers, while GAD67 is the predominant GAD expressed in the postnatal secondary fibers. This pattern correlates well with the expression of Dlx2 and Dlx5, known as upstream regulators of GAD. GABA and GAD are most abundant at the tips of elongating fibers and are absent from organelle-free cells, suggesting their involvement is primarily in shaping of the cytoskeleton during fiber elongation stages. PB - Wiley-Liss, Hoboken T2 - Developmental Dynamics T1 - GAD isoforms exhibit distinct spatiotemporal expression patterns in the developing mouse lens: Correlation with Dlx2 and Dlx5 EP - 3544 IS - 12 SP - 3532 VL - 236 DO - 10.1002/dvdy.21361 ER -
@article{ author = "Kwakowsky, Andrea and Schwirtlich, Marija and Zhang, Qi and Eisenstat, David D. and Erdelyi, Ferenc and Baranyi, Maria and Katarova, Zoya D. and Szabo, Gabor", year = "2007", abstract = "Gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter of the adult nervous system and its biosynthetic enzyme glutamic acid.. decarboxylase (GAD) are abundantly expressed in the embryonic nervous system and are involved in the modulation of cell proliferation, migration, and differentiation. Here we describe for the first time the expression of GABA and embryonic and adult GAD isoforms in the developing mouse lens. We show that the GAD isoforms are sequentially induced with specific spatiotemporal profiles: GAD65 and embryonic GAD isoforms prevail in primary fibers, while GAD67 is the predominant GAD expressed in the postnatal secondary fibers. This pattern correlates well with the expression of Dlx2 and Dlx5, known as upstream regulators of GAD. GABA and GAD are most abundant at the tips of elongating fibers and are absent from organelle-free cells, suggesting their involvement is primarily in shaping of the cytoskeleton during fiber elongation stages.", publisher = "Wiley-Liss, Hoboken", journal = "Developmental Dynamics", title = "GAD isoforms exhibit distinct spatiotemporal expression patterns in the developing mouse lens: Correlation with Dlx2 and Dlx5", pages = "3544-3532", number = "12", volume = "236", doi = "10.1002/dvdy.21361" }
Kwakowsky, A., Schwirtlich, M., Zhang, Q., Eisenstat, D. D., Erdelyi, F., Baranyi, M., Katarova, Z. D.,& Szabo, G.. (2007). GAD isoforms exhibit distinct spatiotemporal expression patterns in the developing mouse lens: Correlation with Dlx2 and Dlx5. in Developmental Dynamics Wiley-Liss, Hoboken., 236(12), 3532-3544. https://doi.org/10.1002/dvdy.21361
Kwakowsky A, Schwirtlich M, Zhang Q, Eisenstat DD, Erdelyi F, Baranyi M, Katarova ZD, Szabo G. GAD isoforms exhibit distinct spatiotemporal expression patterns in the developing mouse lens: Correlation with Dlx2 and Dlx5. in Developmental Dynamics. 2007;236(12):3532-3544. doi:10.1002/dvdy.21361 .
Kwakowsky, Andrea, Schwirtlich, Marija, Zhang, Qi, Eisenstat, David D., Erdelyi, Ferenc, Baranyi, Maria, Katarova, Zoya D., Szabo, Gabor, "GAD isoforms exhibit distinct spatiotemporal expression patterns in the developing mouse lens: Correlation with Dlx2 and Dlx5" in Developmental Dynamics, 236, no. 12 (2007):3532-3544, https://doi.org/10.1002/dvdy.21361 . .