Polymorphisms of tumor-necrosis factor-alpha-7308 and lymphotoxin-alpha+250: Possible modulation of susceptibility to apoptosis in chronic lymphocytic leukemia and non-Hodgkin lymphoma mononuclear cells
Samo za registrovane korisnike
2008
Autori
Jevtovic-Stoimenov, TatjanaKocić, Gordana
Pavlović, Dušica
Macukanović-Golubović, Lana
Marjanović, Goran
Đorđević, Vidosava
Tošić, Nataša
Pavlović, Sonja
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Tumor necrosis factor alpha (TNF-alpha) and lymphotoxin alpha (LT-alpha) have been shown to play an important role in the pathogenesis of limphoproliferative disease. Both cytokines regulate cell-survival and cell-death in leukemic cells. TNF-alpha and LT-alpha are highly produced in chronic lymphotic leukemia (CLL) and non-Hodgkin lymphoma (NHL) patients. Genetic polymorphism within regulatory regions of these cytokine genes can alter their expression levels. This study investigates an influence of TNF-alpha - 308 and LT-alpha + 250 polymorphisms on the activity of alkaline DNase in mononuclear cells of both patient groups as a potent biochemical marker of DNA fragmentation in the terminal phase of apoptosis. Study was performed on mononuclear cells of CLL and NHL patients. SNP were obtained by PCR-RFLP method. The activity of alkaline DNase was measured by spectrophotometric method. The study provided evidence of the influence of TNFG/A genotype and A alleles in the susceptibility to... NHL, since the association of LT-alpha G/G genotype with CLL was observed. High-producing TNF-alpha - 308/LT-alpha + 250 heterozygous haplotype is associated with high NHL incidence. The investigated SNP influence the activity of alkaline DNase in CLL and NHL patients. The observed polymorphisms may modulate susceptibility of leukemic cells to apoptosis by way of DNase activity.
Ključne reči:
TNF-alpha / non-Hodgkin lymphoma / LT-alpha / chronic lymphocytic leukemia / alkaline DNaseIzvor:
Leukemia & Lymphoma, 2008, 49, 11, 2174-2180Izdavač:
- Taylor & Francis Ltd, Abingdon
Finansiranje / projekti:
- Modulatori target mesta genomiksa i proteomiksa redoks ćelijske signalizacije, proliferacije i inflamacije: nove dijagnostičke i terapijske mogućnosti (RS-MESTD-MPN2006-2010-145081)
- Dijagnostički i prognostički značaj biomarkera inflamacije, oksidacionog stresa i smrti ćelije u ishemijskoj bolesti srca (RS-MESTD-MPN2006-2010-145039)
DOI: 10.1080/10428190802381220
ISSN: 1042-8194
PubMed: 19021060
WoS: 000261036800020
Scopus: 2-s2.0-57049112004
Institucija/grupa
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Jevtovic-Stoimenov, Tatjana AU - Kocić, Gordana AU - Pavlović, Dušica AU - Macukanović-Golubović, Lana AU - Marjanović, Goran AU - Đorđević, Vidosava AU - Tošić, Nataša AU - Pavlović, Sonja PY - 2008 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/317 AB - Tumor necrosis factor alpha (TNF-alpha) and lymphotoxin alpha (LT-alpha) have been shown to play an important role in the pathogenesis of limphoproliferative disease. Both cytokines regulate cell-survival and cell-death in leukemic cells. TNF-alpha and LT-alpha are highly produced in chronic lymphotic leukemia (CLL) and non-Hodgkin lymphoma (NHL) patients. Genetic polymorphism within regulatory regions of these cytokine genes can alter their expression levels. This study investigates an influence of TNF-alpha - 308 and LT-alpha + 250 polymorphisms on the activity of alkaline DNase in mononuclear cells of both patient groups as a potent biochemical marker of DNA fragmentation in the terminal phase of apoptosis. Study was performed on mononuclear cells of CLL and NHL patients. SNP were obtained by PCR-RFLP method. The activity of alkaline DNase was measured by spectrophotometric method. The study provided evidence of the influence of TNFG/A genotype and A alleles in the susceptibility to NHL, since the association of LT-alpha G/G genotype with CLL was observed. High-producing TNF-alpha - 308/LT-alpha + 250 heterozygous haplotype is associated with high NHL incidence. The investigated SNP influence the activity of alkaline DNase in CLL and NHL patients. The observed polymorphisms may modulate susceptibility of leukemic cells to apoptosis by way of DNase activity. PB - Taylor & Francis Ltd, Abingdon T2 - Leukemia & Lymphoma T1 - Polymorphisms of tumor-necrosis factor-alpha-7308 and lymphotoxin-alpha+250: Possible modulation of susceptibility to apoptosis in chronic lymphocytic leukemia and non-Hodgkin lymphoma mononuclear cells EP - 2180 IS - 11 SP - 2174 VL - 49 DO - 10.1080/10428190802381220 ER -
@article{ author = "Jevtovic-Stoimenov, Tatjana and Kocić, Gordana and Pavlović, Dušica and Macukanović-Golubović, Lana and Marjanović, Goran and Đorđević, Vidosava and Tošić, Nataša and Pavlović, Sonja", year = "2008", abstract = "Tumor necrosis factor alpha (TNF-alpha) and lymphotoxin alpha (LT-alpha) have been shown to play an important role in the pathogenesis of limphoproliferative disease. Both cytokines regulate cell-survival and cell-death in leukemic cells. TNF-alpha and LT-alpha are highly produced in chronic lymphotic leukemia (CLL) and non-Hodgkin lymphoma (NHL) patients. Genetic polymorphism within regulatory regions of these cytokine genes can alter their expression levels. This study investigates an influence of TNF-alpha - 308 and LT-alpha + 250 polymorphisms on the activity of alkaline DNase in mononuclear cells of both patient groups as a potent biochemical marker of DNA fragmentation in the terminal phase of apoptosis. Study was performed on mononuclear cells of CLL and NHL patients. SNP were obtained by PCR-RFLP method. The activity of alkaline DNase was measured by spectrophotometric method. The study provided evidence of the influence of TNFG/A genotype and A alleles in the susceptibility to NHL, since the association of LT-alpha G/G genotype with CLL was observed. High-producing TNF-alpha - 308/LT-alpha + 250 heterozygous haplotype is associated with high NHL incidence. The investigated SNP influence the activity of alkaline DNase in CLL and NHL patients. The observed polymorphisms may modulate susceptibility of leukemic cells to apoptosis by way of DNase activity.", publisher = "Taylor & Francis Ltd, Abingdon", journal = "Leukemia & Lymphoma", title = "Polymorphisms of tumor-necrosis factor-alpha-7308 and lymphotoxin-alpha+250: Possible modulation of susceptibility to apoptosis in chronic lymphocytic leukemia and non-Hodgkin lymphoma mononuclear cells", pages = "2180-2174", number = "11", volume = "49", doi = "10.1080/10428190802381220" }
Jevtovic-Stoimenov, T., Kocić, G., Pavlović, D., Macukanović-Golubović, L., Marjanović, G., Đorđević, V., Tošić, N.,& Pavlović, S.. (2008). Polymorphisms of tumor-necrosis factor-alpha-7308 and lymphotoxin-alpha+250: Possible modulation of susceptibility to apoptosis in chronic lymphocytic leukemia and non-Hodgkin lymphoma mononuclear cells. in Leukemia & Lymphoma Taylor & Francis Ltd, Abingdon., 49(11), 2174-2180. https://doi.org/10.1080/10428190802381220
Jevtovic-Stoimenov T, Kocić G, Pavlović D, Macukanović-Golubović L, Marjanović G, Đorđević V, Tošić N, Pavlović S. Polymorphisms of tumor-necrosis factor-alpha-7308 and lymphotoxin-alpha+250: Possible modulation of susceptibility to apoptosis in chronic lymphocytic leukemia and non-Hodgkin lymphoma mononuclear cells. in Leukemia & Lymphoma. 2008;49(11):2174-2180. doi:10.1080/10428190802381220 .
Jevtovic-Stoimenov, Tatjana, Kocić, Gordana, Pavlović, Dušica, Macukanović-Golubović, Lana, Marjanović, Goran, Đorđević, Vidosava, Tošić, Nataša, Pavlović, Sonja, "Polymorphisms of tumor-necrosis factor-alpha-7308 and lymphotoxin-alpha+250: Possible modulation of susceptibility to apoptosis in chronic lymphocytic leukemia and non-Hodgkin lymphoma mononuclear cells" in Leukemia & Lymphoma, 49, no. 11 (2008):2174-2180, https://doi.org/10.1080/10428190802381220 . .