Genetic Risk Factors for Arterial Ischemic Stroke in Children: A Possible MTHFR and eNOS Gene-Gene Interplay?
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2009
Authors
Đorđević, Valentina![](/themes/Mirageimagine/images/orcid.png)
Stanković, Marija
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Branković-Srecković, Vesna
Rakićević, Ljiljana
![](/themes/Mirageimagine/images/orcid.png)
Radojković, Dragica
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Article (Published version)
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In order to investigate the influence of genetic factors in childhood stroke, we compared the distributions of mutations/polymorphisms affecting hemostasis and/or endothelial function (factor V [FV] Leiden, factor II [FII] G20210A, methylenetetrahydrofolate reductase [MTHFR] C677T, angiotensin-converting enzyme [ACE] insertion/deletion [1D], and endothelial nitric oxide synthase [eNOS] G894T) among children with stroke and controls. A total number of 26 children with arterial ischemic stroke and a control group of 50 healthy children were included in the study. No statistically significant differences in allelic and genotypic distribution were detected in comparisons between groups. However, when combined genotypes were analyzed, statistical significance was observed for the association of MTHFR CT and eNOS IT gene variants. The results Of our study Suggest that this genotype combination represents a risk factor of 7.2 (P =. 017) for arterial ischemic stroke in children.
Keywords:
MTHFR C677T / factor V / eNOS G894T / arterial ischemic strokeSource:
Journal of Child Neurology, 2009, 24, 7, 823-827Publisher:
- Sage Publications Inc, Thousand Oaks
Funding / projects:
- Strukturalni elementi genoma u modulaciji fenotipa (RS-MESTD-MPN2006-2010-143051)
DOI: 10.1177/0883073808330164
ISSN: 0883-0738
PubMed: 19372095
WoS: 000267347000006
Scopus: 2-s2.0-67949117258
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Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Đorđević, Valentina AU - Stanković, Marija AU - Branković-Srecković, Vesna AU - Rakićević, Ljiljana AU - Radojković, Dragica PY - 2009 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/344 AB - In order to investigate the influence of genetic factors in childhood stroke, we compared the distributions of mutations/polymorphisms affecting hemostasis and/or endothelial function (factor V [FV] Leiden, factor II [FII] G20210A, methylenetetrahydrofolate reductase [MTHFR] C677T, angiotensin-converting enzyme [ACE] insertion/deletion [1D], and endothelial nitric oxide synthase [eNOS] G894T) among children with stroke and controls. A total number of 26 children with arterial ischemic stroke and a control group of 50 healthy children were included in the study. No statistically significant differences in allelic and genotypic distribution were detected in comparisons between groups. However, when combined genotypes were analyzed, statistical significance was observed for the association of MTHFR CT and eNOS IT gene variants. The results Of our study Suggest that this genotype combination represents a risk factor of 7.2 (P =. 017) for arterial ischemic stroke in children. PB - Sage Publications Inc, Thousand Oaks T2 - Journal of Child Neurology T1 - Genetic Risk Factors for Arterial Ischemic Stroke in Children: A Possible MTHFR and eNOS Gene-Gene Interplay? EP - 827 IS - 7 SP - 823 VL - 24 DO - 10.1177/0883073808330164 ER -
@article{ author = "Đorđević, Valentina and Stanković, Marija and Branković-Srecković, Vesna and Rakićević, Ljiljana and Radojković, Dragica", year = "2009", abstract = "In order to investigate the influence of genetic factors in childhood stroke, we compared the distributions of mutations/polymorphisms affecting hemostasis and/or endothelial function (factor V [FV] Leiden, factor II [FII] G20210A, methylenetetrahydrofolate reductase [MTHFR] C677T, angiotensin-converting enzyme [ACE] insertion/deletion [1D], and endothelial nitric oxide synthase [eNOS] G894T) among children with stroke and controls. A total number of 26 children with arterial ischemic stroke and a control group of 50 healthy children were included in the study. No statistically significant differences in allelic and genotypic distribution were detected in comparisons between groups. However, when combined genotypes were analyzed, statistical significance was observed for the association of MTHFR CT and eNOS IT gene variants. The results Of our study Suggest that this genotype combination represents a risk factor of 7.2 (P =. 017) for arterial ischemic stroke in children.", publisher = "Sage Publications Inc, Thousand Oaks", journal = "Journal of Child Neurology", title = "Genetic Risk Factors for Arterial Ischemic Stroke in Children: A Possible MTHFR and eNOS Gene-Gene Interplay?", pages = "827-823", number = "7", volume = "24", doi = "10.1177/0883073808330164" }
Đorđević, V., Stanković, M., Branković-Srecković, V., Rakićević, L.,& Radojković, D.. (2009). Genetic Risk Factors for Arterial Ischemic Stroke in Children: A Possible MTHFR and eNOS Gene-Gene Interplay?. in Journal of Child Neurology Sage Publications Inc, Thousand Oaks., 24(7), 823-827. https://doi.org/10.1177/0883073808330164
Đorđević V, Stanković M, Branković-Srecković V, Rakićević L, Radojković D. Genetic Risk Factors for Arterial Ischemic Stroke in Children: A Possible MTHFR and eNOS Gene-Gene Interplay?. in Journal of Child Neurology. 2009;24(7):823-827. doi:10.1177/0883073808330164 .
Đorđević, Valentina, Stanković, Marija, Branković-Srecković, Vesna, Rakićević, Ljiljana, Radojković, Dragica, "Genetic Risk Factors for Arterial Ischemic Stroke in Children: A Possible MTHFR and eNOS Gene-Gene Interplay?" in Journal of Child Neurology, 24, no. 7 (2009):823-827, https://doi.org/10.1177/0883073808330164 . .