The prothrombin factor ii g20210a mutation with pulmonary thromboembolism and a normal level of fibrin degradation products
2009
Authors
Nagorni-Obradović, L. J.Miljić, Predrag
Đorđević, Valentina
Pesut, D. P.
Jovanović, D.
Stojsić, J.
Stević, R.
Radojković, Dragica
Article (Published version)
Metadata
Show full item recordAbstract
Diagnosis of pulmonary thromboembolism (PTE) usually includes clinical pretest probability assessment, testing for specific degradation products of cross-linked fibrin (D-dimer) and imaging studies. Patients with radiological findings attributable to pulmonary infarction and normal D-dimer level, may present a diagnostic and therapeutic challenge. A 37-year-old Caucasian female had episodes of hemoptysis, and bilateral pulmonary nodular infiltrates on chest radiograph and computerized tomography. The plasma D-dimer level was normal, perfusion lung scan was not conclusive and histological examination of an open lung biopsy revealed recent thrombotic pulmonary infarction. She deteriorated and more perfusion defects were detected on perfusion lung scan. Genetic analysis revealed her to be a carrier of the prothrombin factor II (FII) G20210A mutation.
Keywords:
Thromboembolism / Surgical procedure / Risk factor / Factor II (FII) G20210A mutation / Cross-linked fibrin (D-dimer)Source:
Balkan Journal of Medical Genetics, 2009, 12, 2, 69-75Publisher:
- Macedonian Acad Sciences Arts, Skopje
Funding / projects:
- Strukturalni elementi genoma u modulaciji fenotipa (RS-MESTD-MPN2006-2010-143051)
- Molekularno genetski markeri klonskog preobražaja matičnih ćelija hematopoeze (RS-MESTD-MPN2006-2010-145061)
DOI: 10.2478/v10034-010-0007-7
ISSN: 1311-0160
WoS: 000276575500010
Scopus: 2-s2.0-77649140897
Collections
Institution/Community
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Nagorni-Obradović, L. J. AU - Miljić, Predrag AU - Đorđević, Valentina AU - Pesut, D. P. AU - Jovanović, D. AU - Stojsić, J. AU - Stević, R. AU - Radojković, Dragica PY - 2009 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/372 AB - Diagnosis of pulmonary thromboembolism (PTE) usually includes clinical pretest probability assessment, testing for specific degradation products of cross-linked fibrin (D-dimer) and imaging studies. Patients with radiological findings attributable to pulmonary infarction and normal D-dimer level, may present a diagnostic and therapeutic challenge. A 37-year-old Caucasian female had episodes of hemoptysis, and bilateral pulmonary nodular infiltrates on chest radiograph and computerized tomography. The plasma D-dimer level was normal, perfusion lung scan was not conclusive and histological examination of an open lung biopsy revealed recent thrombotic pulmonary infarction. She deteriorated and more perfusion defects were detected on perfusion lung scan. Genetic analysis revealed her to be a carrier of the prothrombin factor II (FII) G20210A mutation. PB - Macedonian Acad Sciences Arts, Skopje T2 - Balkan Journal of Medical Genetics T1 - The prothrombin factor ii g20210a mutation with pulmonary thromboembolism and a normal level of fibrin degradation products EP - 75 IS - 2 SP - 69 VL - 12 DO - 10.2478/v10034-010-0007-7 ER -
@article{ author = "Nagorni-Obradović, L. J. and Miljić, Predrag and Đorđević, Valentina and Pesut, D. P. and Jovanović, D. and Stojsić, J. and Stević, R. and Radojković, Dragica", year = "2009", abstract = "Diagnosis of pulmonary thromboembolism (PTE) usually includes clinical pretest probability assessment, testing for specific degradation products of cross-linked fibrin (D-dimer) and imaging studies. Patients with radiological findings attributable to pulmonary infarction and normal D-dimer level, may present a diagnostic and therapeutic challenge. A 37-year-old Caucasian female had episodes of hemoptysis, and bilateral pulmonary nodular infiltrates on chest radiograph and computerized tomography. The plasma D-dimer level was normal, perfusion lung scan was not conclusive and histological examination of an open lung biopsy revealed recent thrombotic pulmonary infarction. She deteriorated and more perfusion defects were detected on perfusion lung scan. Genetic analysis revealed her to be a carrier of the prothrombin factor II (FII) G20210A mutation.", publisher = "Macedonian Acad Sciences Arts, Skopje", journal = "Balkan Journal of Medical Genetics", title = "The prothrombin factor ii g20210a mutation with pulmonary thromboembolism and a normal level of fibrin degradation products", pages = "75-69", number = "2", volume = "12", doi = "10.2478/v10034-010-0007-7" }
Nagorni-Obradović, L. J., Miljić, P., Đorđević, V., Pesut, D. P., Jovanović, D., Stojsić, J., Stević, R.,& Radojković, D.. (2009). The prothrombin factor ii g20210a mutation with pulmonary thromboembolism and a normal level of fibrin degradation products. in Balkan Journal of Medical Genetics Macedonian Acad Sciences Arts, Skopje., 12(2), 69-75. https://doi.org/10.2478/v10034-010-0007-7
Nagorni-Obradović LJ, Miljić P, Đorđević V, Pesut DP, Jovanović D, Stojsić J, Stević R, Radojković D. The prothrombin factor ii g20210a mutation with pulmonary thromboembolism and a normal level of fibrin degradation products. in Balkan Journal of Medical Genetics. 2009;12(2):69-75. doi:10.2478/v10034-010-0007-7 .
Nagorni-Obradović, L. J., Miljić, Predrag, Đorđević, Valentina, Pesut, D. P., Jovanović, D., Stojsić, J., Stević, R., Radojković, Dragica, "The prothrombin factor ii g20210a mutation with pulmonary thromboembolism and a normal level of fibrin degradation products" in Balkan Journal of Medical Genetics, 12, no. 2 (2009):69-75, https://doi.org/10.2478/v10034-010-0007-7 . .