Novel ORC4L Gene Mutation in B-Cell Lymphoproliferative Disorders
Само за регистроване кориснике
2009
Аутори
Radojković, MilicaRistić, Slobodan
Divac Rankov, Aleksandra
Tomić, Branko
Arestorović, Aleksandra
Radojković, Dragica
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
B-cell lymphoproliferative disorders are characterized by marked genetic, morphological, and clinical heterogeneity. The identification of prognostic markers could help to develop risk-adapted treatment strategies. Because proliferation of cells is essential for tumor growth, analysis of the cell cycle might give additional information on tumor progression and clinical behavior. Because initiation of DNA replication represents a significant step in cell division, it is worthwhile to focus the attention to the origin recognition complex (ORC), protein complex essential for initiation of DNA replication. Studies have already shown that ORC-associated factors give a more accurate assessment of cell proliferation than previous markers for many types of malignancies, but so far there have been no studies of eventual role of ORC4L in B-cell lymphoproliferative disorders. Here, we describe 3 patients with B-cell lymphoproliferative disorders (2 with non-Hodgkin lymphoma and I with nonsecretor...y multiple myeloma) carrying a novel A286V mutation within ORC4L gene. All 3 patients were in the advanced stage of disease, but their response to the chemotherapy treatment was good and they achieved complete clinical remission in a relatively short period. Although the functional relevance of this mutation has not yet been elucidated, our observation raises a possibility that A286V mutation, which is constitutively present in these patients, might represent a favorable prognostic marker in B-cell lymphoproliferative disorders.
Кључне речи:
Prognosis / ORC4L gene mutation / B-cell lymphoproliferative disordersИзвор:
American Journal of the Medical Sciences, 2009, 338, 6, 527-529Издавач:
- Lippincott Williams & Wilkins, Philadelphia
Финансирање / пројекти:
- Структурални елементи генома у модулацији фенотипа (RS-MESTD-MPN2006-2010-143051)
DOI: 10.1097/MAJ.0b013e3181b7f17c
ISSN: 0002-9629
PubMed: 20010161
WoS: 000272811200023
Scopus: 2-s2.0-73949125253
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Radojković, Milica AU - Ristić, Slobodan AU - Divac Rankov, Aleksandra AU - Tomić, Branko AU - Arestorović, Aleksandra AU - Radojković, Dragica PY - 2009 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/380 AB - B-cell lymphoproliferative disorders are characterized by marked genetic, morphological, and clinical heterogeneity. The identification of prognostic markers could help to develop risk-adapted treatment strategies. Because proliferation of cells is essential for tumor growth, analysis of the cell cycle might give additional information on tumor progression and clinical behavior. Because initiation of DNA replication represents a significant step in cell division, it is worthwhile to focus the attention to the origin recognition complex (ORC), protein complex essential for initiation of DNA replication. Studies have already shown that ORC-associated factors give a more accurate assessment of cell proliferation than previous markers for many types of malignancies, but so far there have been no studies of eventual role of ORC4L in B-cell lymphoproliferative disorders. Here, we describe 3 patients with B-cell lymphoproliferative disorders (2 with non-Hodgkin lymphoma and I with nonsecretory multiple myeloma) carrying a novel A286V mutation within ORC4L gene. All 3 patients were in the advanced stage of disease, but their response to the chemotherapy treatment was good and they achieved complete clinical remission in a relatively short period. Although the functional relevance of this mutation has not yet been elucidated, our observation raises a possibility that A286V mutation, which is constitutively present in these patients, might represent a favorable prognostic marker in B-cell lymphoproliferative disorders. PB - Lippincott Williams & Wilkins, Philadelphia T2 - American Journal of the Medical Sciences T1 - Novel ORC4L Gene Mutation in B-Cell Lymphoproliferative Disorders EP - 529 IS - 6 SP - 527 VL - 338 DO - 10.1097/MAJ.0b013e3181b7f17c ER -
@article{ author = "Radojković, Milica and Ristić, Slobodan and Divac Rankov, Aleksandra and Tomić, Branko and Arestorović, Aleksandra and Radojković, Dragica", year = "2009", abstract = "B-cell lymphoproliferative disorders are characterized by marked genetic, morphological, and clinical heterogeneity. The identification of prognostic markers could help to develop risk-adapted treatment strategies. Because proliferation of cells is essential for tumor growth, analysis of the cell cycle might give additional information on tumor progression and clinical behavior. Because initiation of DNA replication represents a significant step in cell division, it is worthwhile to focus the attention to the origin recognition complex (ORC), protein complex essential for initiation of DNA replication. Studies have already shown that ORC-associated factors give a more accurate assessment of cell proliferation than previous markers for many types of malignancies, but so far there have been no studies of eventual role of ORC4L in B-cell lymphoproliferative disorders. Here, we describe 3 patients with B-cell lymphoproliferative disorders (2 with non-Hodgkin lymphoma and I with nonsecretory multiple myeloma) carrying a novel A286V mutation within ORC4L gene. All 3 patients were in the advanced stage of disease, but their response to the chemotherapy treatment was good and they achieved complete clinical remission in a relatively short period. Although the functional relevance of this mutation has not yet been elucidated, our observation raises a possibility that A286V mutation, which is constitutively present in these patients, might represent a favorable prognostic marker in B-cell lymphoproliferative disorders.", publisher = "Lippincott Williams & Wilkins, Philadelphia", journal = "American Journal of the Medical Sciences", title = "Novel ORC4L Gene Mutation in B-Cell Lymphoproliferative Disorders", pages = "529-527", number = "6", volume = "338", doi = "10.1097/MAJ.0b013e3181b7f17c" }
Radojković, M., Ristić, S., Divac Rankov, A., Tomić, B., Arestorović, A.,& Radojković, D.. (2009). Novel ORC4L Gene Mutation in B-Cell Lymphoproliferative Disorders. in American Journal of the Medical Sciences Lippincott Williams & Wilkins, Philadelphia., 338(6), 527-529. https://doi.org/10.1097/MAJ.0b013e3181b7f17c
Radojković M, Ristić S, Divac Rankov A, Tomić B, Arestorović A, Radojković D. Novel ORC4L Gene Mutation in B-Cell Lymphoproliferative Disorders. in American Journal of the Medical Sciences. 2009;338(6):527-529. doi:10.1097/MAJ.0b013e3181b7f17c .
Radojković, Milica, Ristić, Slobodan, Divac Rankov, Aleksandra, Tomić, Branko, Arestorović, Aleksandra, Radojković, Dragica, "Novel ORC4L Gene Mutation in B-Cell Lymphoproliferative Disorders" in American Journal of the Medical Sciences, 338, no. 6 (2009):527-529, https://doi.org/10.1097/MAJ.0b013e3181b7f17c . .