Analiza mutacije u kodonu 12 gena K-ras u pankreasnom tkivu pacijenata sa karcinomom pankreasa
Analysis of K-ras gene codon 12 mutation in pancreatic tissue of patients with pancreatic cancer
2009
Authors
Nikolić, AleksandraKnežević, S.
Krsmanović, Mila
Micev, M.
Ristanović, M.
Radojković, Dragica
Article (Published version)
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Ovo istraživanje je imalo za cilj da se analizira prisustvo mutacije u kodonu 12 gena K-ras u pankreasnom tkivu pacijenata sa karcinomom pankreasa i da se proceni da li ova mutacija predstavlja potencijalni molekularni marker za karcinom pankreasa u srpskoj populaciji. Istraživanje je obuhvatilo analizu 40 uzoraka tkiva pankreasa pacijenata sa kliničkom dijagnozom karcinoma pankreasa. Prisustvo mutacije u kodonu 12 gena K-ras analizirano je metodom PCR-RFLP (polymerase chain reaction - restriction fragment length polymorphism). Rezultati istraživanja ukazuju da je mutacija u kodonu 12 gena K-ras u tkivu pankreasa prisutna sa visokom učestalošću (66 %) kod pacijenata sa karcinomom pankreasa.
The aim of this study was to analyze K-ras codon 12 mutation in the pancreatic tissue of Serbian patients with pancreatic cancer and assess whether the given mutation can be used as a molecular marker for this disease. The study was performed on pancreatic tissue samples obtained from 40 patients with clinical diagnosis of pancreatic cancer. The presence of K-ras codon 12 mutation was analyzed by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Our study showed that K-ras mutation is present with a high frequency (66%) in the pancreatic tissue of patients with pancretic cancer.
Keywords:
pancreatic cancer / molecular marker / K-ras codon 12 mutationSource:
Archives of Biological Sciences, 2009, 61, 4, 623-629Publisher:
- Srpsko biološko društvo, Beograd, i dr.
Funding / projects:
- Strukturalni elementi genoma u modulaciji fenotipa (RS-MESTD-MPN2006-2010-143051)
DOI: 10.2298/ABS0904623N
ISSN: 0354-4664
WoS: 000273203500008
Scopus: 2-s2.0-77949889509
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Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Nikolić, Aleksandra AU - Knežević, S. AU - Krsmanović, Mila AU - Micev, M. AU - Ristanović, M. AU - Radojković, Dragica PY - 2009 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/382 AB - Ovo istraživanje je imalo za cilj da se analizira prisustvo mutacije u kodonu 12 gena K-ras u pankreasnom tkivu pacijenata sa karcinomom pankreasa i da se proceni da li ova mutacija predstavlja potencijalni molekularni marker za karcinom pankreasa u srpskoj populaciji. Istraživanje je obuhvatilo analizu 40 uzoraka tkiva pankreasa pacijenata sa kliničkom dijagnozom karcinoma pankreasa. Prisustvo mutacije u kodonu 12 gena K-ras analizirano je metodom PCR-RFLP (polymerase chain reaction - restriction fragment length polymorphism). Rezultati istraživanja ukazuju da je mutacija u kodonu 12 gena K-ras u tkivu pankreasa prisutna sa visokom učestalošću (66 %) kod pacijenata sa karcinomom pankreasa. AB - The aim of this study was to analyze K-ras codon 12 mutation in the pancreatic tissue of Serbian patients with pancreatic cancer and assess whether the given mutation can be used as a molecular marker for this disease. The study was performed on pancreatic tissue samples obtained from 40 patients with clinical diagnosis of pancreatic cancer. The presence of K-ras codon 12 mutation was analyzed by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Our study showed that K-ras mutation is present with a high frequency (66%) in the pancreatic tissue of patients with pancretic cancer. PB - Srpsko biološko društvo, Beograd, i dr. T2 - Archives of Biological Sciences T1 - Analiza mutacije u kodonu 12 gena K-ras u pankreasnom tkivu pacijenata sa karcinomom pankreasa T1 - Analysis of K-ras gene codon 12 mutation in pancreatic tissue of patients with pancreatic cancer EP - 629 IS - 4 SP - 623 VL - 61 DO - 10.2298/ABS0904623N ER -
@article{ author = "Nikolić, Aleksandra and Knežević, S. and Krsmanović, Mila and Micev, M. and Ristanović, M. and Radojković, Dragica", year = "2009", abstract = "Ovo istraživanje je imalo za cilj da se analizira prisustvo mutacije u kodonu 12 gena K-ras u pankreasnom tkivu pacijenata sa karcinomom pankreasa i da se proceni da li ova mutacija predstavlja potencijalni molekularni marker za karcinom pankreasa u srpskoj populaciji. Istraživanje je obuhvatilo analizu 40 uzoraka tkiva pankreasa pacijenata sa kliničkom dijagnozom karcinoma pankreasa. Prisustvo mutacije u kodonu 12 gena K-ras analizirano je metodom PCR-RFLP (polymerase chain reaction - restriction fragment length polymorphism). Rezultati istraživanja ukazuju da je mutacija u kodonu 12 gena K-ras u tkivu pankreasa prisutna sa visokom učestalošću (66 %) kod pacijenata sa karcinomom pankreasa., The aim of this study was to analyze K-ras codon 12 mutation in the pancreatic tissue of Serbian patients with pancreatic cancer and assess whether the given mutation can be used as a molecular marker for this disease. The study was performed on pancreatic tissue samples obtained from 40 patients with clinical diagnosis of pancreatic cancer. The presence of K-ras codon 12 mutation was analyzed by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Our study showed that K-ras mutation is present with a high frequency (66%) in the pancreatic tissue of patients with pancretic cancer.", publisher = "Srpsko biološko društvo, Beograd, i dr.", journal = "Archives of Biological Sciences", title = "Analiza mutacije u kodonu 12 gena K-ras u pankreasnom tkivu pacijenata sa karcinomom pankreasa, Analysis of K-ras gene codon 12 mutation in pancreatic tissue of patients with pancreatic cancer", pages = "629-623", number = "4", volume = "61", doi = "10.2298/ABS0904623N" }
Nikolić, A., Knežević, S., Krsmanović, M., Micev, M., Ristanović, M.,& Radojković, D.. (2009). Analiza mutacije u kodonu 12 gena K-ras u pankreasnom tkivu pacijenata sa karcinomom pankreasa. in Archives of Biological Sciences Srpsko biološko društvo, Beograd, i dr.., 61(4), 623-629. https://doi.org/10.2298/ABS0904623N
Nikolić A, Knežević S, Krsmanović M, Micev M, Ristanović M, Radojković D. Analiza mutacije u kodonu 12 gena K-ras u pankreasnom tkivu pacijenata sa karcinomom pankreasa. in Archives of Biological Sciences. 2009;61(4):623-629. doi:10.2298/ABS0904623N .
Nikolić, Aleksandra, Knežević, S., Krsmanović, Mila, Micev, M., Ristanović, M., Radojković, Dragica, "Analiza mutacije u kodonu 12 gena K-ras u pankreasnom tkivu pacijenata sa karcinomom pankreasa" in Archives of Biological Sciences, 61, no. 4 (2009):623-629, https://doi.org/10.2298/ABS0904623N . .