Ekspresija SoX3 gena indukovana retinoičnom kiselinom u NT2/D1 ćelijama je nezavisna od RXr homodimera
Retinoic acid-induced SoX3 gene expression in NT2/D1 cells is RXR homodimer-independent
Apstrakt
Sox3/SOX3 gen je uključen u kontrolu razvića nervnog sistema. Naša prethodna istraživanja su pokazala da tokom neuralne indukcije NT2/D1 ćelija retinoičnom kiselinom (RK) dolazi do promene ekspresije humanog SOX3 gena. Takođe, pokazali smo da su RXR retinoidni receptori glavni posrednici efekta RK na SOX3 ekspresiju, dok su članovi RAR familije receptora isključeni kao njihovi heterodimerni partneri u ovom signalnom putu. Rezultati predstavljeni u ovom radu ukazuju da je aktivacija SOX3 gena retinoičnom kiselinom nezavisna od RXR homodimera. Ova izučavanja ekspresije SOX3 gena su značajna za buduća istraživanja uticaja koji ovaj gen ima na različite aspekte normalnog i patološkog razvića.
The Sox3/SOX3 gene is implicated in the control of nervous system development. We previously demonstrated modulation of human SOX3 gene expression during neural induction of NT2/D1 cells by retinoic acid (RA). Also, we accurately verified RXR retinoid receptors as major mediators of the effect of RA on SOX3 expression, and excluded RARs as its heterodimeric partners in RA-SOX3 signaling. Here we present evidence that activation of the SOX3 gene by RA is not RXR homodimer-dependent. The described line of SOX3 gene expression studies is valuable for future investigation of the impact that this gene has multiple aspects of normal and pathological development.
Ključne reči:
SOX3 gene / RXR / retinoic acid / NT2/D1Izvor:
Archives of Biological Sciences, 2009, 61, 4, 631-638Izdavač:
- Srpsko biološko društvo, Beograd, i dr.
Finansiranje / projekti:
- Izučavanje regulacije ekspresije i funkcije humanih SOX gena (RS-MESTD-MPN2006-2010-143028)
DOI: 10.2298/ABS0904631S
ISSN: 0354-4664
WoS: 000273203500009
Scopus: 2-s2.0-77950123046
Institucija/grupa
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Savić, Tijana AU - Stevanović, Milena AU - Nikčević, Gordana PY - 2009 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/383 AB - Sox3/SOX3 gen je uključen u kontrolu razvića nervnog sistema. Naša prethodna istraživanja su pokazala da tokom neuralne indukcije NT2/D1 ćelija retinoičnom kiselinom (RK) dolazi do promene ekspresije humanog SOX3 gena. Takođe, pokazali smo da su RXR retinoidni receptori glavni posrednici efekta RK na SOX3 ekspresiju, dok su članovi RAR familije receptora isključeni kao njihovi heterodimerni partneri u ovom signalnom putu. Rezultati predstavljeni u ovom radu ukazuju da je aktivacija SOX3 gena retinoičnom kiselinom nezavisna od RXR homodimera. Ova izučavanja ekspresije SOX3 gena su značajna za buduća istraživanja uticaja koji ovaj gen ima na različite aspekte normalnog i patološkog razvića. AB - The Sox3/SOX3 gene is implicated in the control of nervous system development. We previously demonstrated modulation of human SOX3 gene expression during neural induction of NT2/D1 cells by retinoic acid (RA). Also, we accurately verified RXR retinoid receptors as major mediators of the effect of RA on SOX3 expression, and excluded RARs as its heterodimeric partners in RA-SOX3 signaling. Here we present evidence that activation of the SOX3 gene by RA is not RXR homodimer-dependent. The described line of SOX3 gene expression studies is valuable for future investigation of the impact that this gene has multiple aspects of normal and pathological development. PB - Srpsko biološko društvo, Beograd, i dr. T2 - Archives of Biological Sciences T1 - Ekspresija SoX3 gena indukovana retinoičnom kiselinom u NT2/D1 ćelijama je nezavisna od RXr homodimera T1 - Retinoic acid-induced SoX3 gene expression in NT2/D1 cells is RXR homodimer-independent EP - 638 IS - 4 SP - 631 VL - 61 DO - 10.2298/ABS0904631S ER -
@article{ author = "Savić, Tijana and Stevanović, Milena and Nikčević, Gordana", year = "2009", abstract = "Sox3/SOX3 gen je uključen u kontrolu razvića nervnog sistema. Naša prethodna istraživanja su pokazala da tokom neuralne indukcije NT2/D1 ćelija retinoičnom kiselinom (RK) dolazi do promene ekspresije humanog SOX3 gena. Takođe, pokazali smo da su RXR retinoidni receptori glavni posrednici efekta RK na SOX3 ekspresiju, dok su članovi RAR familije receptora isključeni kao njihovi heterodimerni partneri u ovom signalnom putu. Rezultati predstavljeni u ovom radu ukazuju da je aktivacija SOX3 gena retinoičnom kiselinom nezavisna od RXR homodimera. Ova izučavanja ekspresije SOX3 gena su značajna za buduća istraživanja uticaja koji ovaj gen ima na različite aspekte normalnog i patološkog razvića., The Sox3/SOX3 gene is implicated in the control of nervous system development. We previously demonstrated modulation of human SOX3 gene expression during neural induction of NT2/D1 cells by retinoic acid (RA). Also, we accurately verified RXR retinoid receptors as major mediators of the effect of RA on SOX3 expression, and excluded RARs as its heterodimeric partners in RA-SOX3 signaling. Here we present evidence that activation of the SOX3 gene by RA is not RXR homodimer-dependent. The described line of SOX3 gene expression studies is valuable for future investigation of the impact that this gene has multiple aspects of normal and pathological development.", publisher = "Srpsko biološko društvo, Beograd, i dr.", journal = "Archives of Biological Sciences", title = "Ekspresija SoX3 gena indukovana retinoičnom kiselinom u NT2/D1 ćelijama je nezavisna od RXr homodimera, Retinoic acid-induced SoX3 gene expression in NT2/D1 cells is RXR homodimer-independent", pages = "638-631", number = "4", volume = "61", doi = "10.2298/ABS0904631S" }
Savić, T., Stevanović, M.,& Nikčević, G.. (2009). Ekspresija SoX3 gena indukovana retinoičnom kiselinom u NT2/D1 ćelijama je nezavisna od RXr homodimera. in Archives of Biological Sciences Srpsko biološko društvo, Beograd, i dr.., 61(4), 631-638. https://doi.org/10.2298/ABS0904631S
Savić T, Stevanović M, Nikčević G. Ekspresija SoX3 gena indukovana retinoičnom kiselinom u NT2/D1 ćelijama je nezavisna od RXr homodimera. in Archives of Biological Sciences. 2009;61(4):631-638. doi:10.2298/ABS0904631S .
Savić, Tijana, Stevanović, Milena, Nikčević, Gordana, "Ekspresija SoX3 gena indukovana retinoičnom kiselinom u NT2/D1 ćelijama je nezavisna od RXr homodimera" in Archives of Biological Sciences, 61, no. 4 (2009):631-638, https://doi.org/10.2298/ABS0904631S . .