Single institute study of FLT3 mutation in acute myeloid leukemia with near tetraploidy in Serbia
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2009
Authors
Jurisić, VladimirPavlović, Sonja
Čolović, Nataša
Đorđević, Vesna
Bunjevacki, Vera
Janković, Gradimir
Colović, Milica
Article (Published version)
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Show full item recordAbstract
Patients with de novo acute myeloid leukemia (AML) and near-tetraploid or completely tetraploid karyotype at presentation are rare. We present four patients with near-tetraploidy/tetraploidy in a cohort of 426 consecutive AML patients (0.98%) in respect to their cytogenetic findings, immunophenotype pattern, response to chemotherapy, course of disease and molecular analyses including tyrosine kinase receptor FLT3 gene, NRAS gene, and tumour suppressor gene, p53. We have found FLT3/ITD mutation only in one patient among the four with near-tetraploidy. The main finding is that these patients had a variable clinical course, with two having a long period of remission (36 and 12 months) and two died, not having achieved remission.
Keywords:
tetraploidy/near-tetraploidy / p53 tumor suppressor gene / NRAS gene / human genetics / FLT3/ITD mutation / acute myeloid leukemia (AML)Source:
Journal of Genetics, 2009, 88, 2, 149-152Publisher:
- Indian Acad Sciences, Bangalore
Funding / projects:
- Molekularno genetski markeri klonskog preobražaja matičnih ćelija hematopoeze (RS-MESTD-MPN2006-2010-145061)
DOI: 10.1007/s12041-009-0022-1
ISSN: 0022-1333
PubMed: 19700852
WoS: 000269420700002
Scopus: 2-s2.0-70350761915
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Institution/Community
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Jurisić, Vladimir AU - Pavlović, Sonja AU - Čolović, Nataša AU - Đorđević, Vesna AU - Bunjevacki, Vera AU - Janković, Gradimir AU - Colović, Milica PY - 2009 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/391 AB - Patients with de novo acute myeloid leukemia (AML) and near-tetraploid or completely tetraploid karyotype at presentation are rare. We present four patients with near-tetraploidy/tetraploidy in a cohort of 426 consecutive AML patients (0.98%) in respect to their cytogenetic findings, immunophenotype pattern, response to chemotherapy, course of disease and molecular analyses including tyrosine kinase receptor FLT3 gene, NRAS gene, and tumour suppressor gene, p53. We have found FLT3/ITD mutation only in one patient among the four with near-tetraploidy. The main finding is that these patients had a variable clinical course, with two having a long period of remission (36 and 12 months) and two died, not having achieved remission. PB - Indian Acad Sciences, Bangalore T2 - Journal of Genetics T1 - Single institute study of FLT3 mutation in acute myeloid leukemia with near tetraploidy in Serbia EP - 152 IS - 2 SP - 149 VL - 88 DO - 10.1007/s12041-009-0022-1 ER -
@article{ author = "Jurisić, Vladimir and Pavlović, Sonja and Čolović, Nataša and Đorđević, Vesna and Bunjevacki, Vera and Janković, Gradimir and Colović, Milica", year = "2009", abstract = "Patients with de novo acute myeloid leukemia (AML) and near-tetraploid or completely tetraploid karyotype at presentation are rare. We present four patients with near-tetraploidy/tetraploidy in a cohort of 426 consecutive AML patients (0.98%) in respect to their cytogenetic findings, immunophenotype pattern, response to chemotherapy, course of disease and molecular analyses including tyrosine kinase receptor FLT3 gene, NRAS gene, and tumour suppressor gene, p53. We have found FLT3/ITD mutation only in one patient among the four with near-tetraploidy. The main finding is that these patients had a variable clinical course, with two having a long period of remission (36 and 12 months) and two died, not having achieved remission.", publisher = "Indian Acad Sciences, Bangalore", journal = "Journal of Genetics", title = "Single institute study of FLT3 mutation in acute myeloid leukemia with near tetraploidy in Serbia", pages = "152-149", number = "2", volume = "88", doi = "10.1007/s12041-009-0022-1" }
Jurisić, V., Pavlović, S., Čolović, N., Đorđević, V., Bunjevacki, V., Janković, G.,& Colović, M.. (2009). Single institute study of FLT3 mutation in acute myeloid leukemia with near tetraploidy in Serbia. in Journal of Genetics Indian Acad Sciences, Bangalore., 88(2), 149-152. https://doi.org/10.1007/s12041-009-0022-1
Jurisić V, Pavlović S, Čolović N, Đorđević V, Bunjevacki V, Janković G, Colović M. Single institute study of FLT3 mutation in acute myeloid leukemia with near tetraploidy in Serbia. in Journal of Genetics. 2009;88(2):149-152. doi:10.1007/s12041-009-0022-1 .
Jurisić, Vladimir, Pavlović, Sonja, Čolović, Nataša, Đorđević, Vesna, Bunjevacki, Vera, Janković, Gradimir, Colović, Milica, "Single institute study of FLT3 mutation in acute myeloid leukemia with near tetraploidy in Serbia" in Journal of Genetics, 88, no. 2 (2009):149-152, https://doi.org/10.1007/s12041-009-0022-1 . .