Comparative Analysis of SOX3 Protein Orthologs: Expansion of Homopolymeric Amino Acid Tracts During Vertebrate Evolution
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2010
Authors
Mojsin, MarijaKovačević Grujičić, Nataša
Krstić, Aleksandar
Popović, Jelena
Milivojević, Milena
Stevanović, Milena
Article (Published version)
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To understand more fully the structure and evolution of the SOX3 protein, we comparatively analyzed its orthologs in vertebrates. Since complex disorders are associated with human SOX3 polyalanine expansions, our investigation focused on both compositional and evolutionary analysis of various homopolymeric amino acid tracts observed in SOX3 orthologs. Our analysis revealed that the observed homopolymeric alanine, glycine, and proline tracts are mammal-specific, except for one polyglycine tract present in birds. Since it is likely that the SOX3 protein acquired additional roles in brain development in Eutheria, we might speculate that development of novel brain functions during the course of evolution was affected, at least in part, by such structural-functional changes in the SOX3 protein.
Keywords:
SOX3 protein / Polyalanine expansion / Homopolymeric amino acid tract / Comparative protein analysisSource:
Biochemical Genetics, 2010, 48, 7-8, 612-623Publisher:
- Springer/Plenum Publishers, New York
Funding / projects:
- Izučavanje regulacije ekspresije i funkcije humanih SOX gena (RS-MESTD-MPN2006-2010-143028)
DOI: 10.1007/s10528-010-9343-2
ISSN: 0006-2928
PubMed: 20495863
WoS: 000279704800006
Scopus: 2-s2.0-77956191342
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Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Mojsin, Marija AU - Kovačević Grujičić, Nataša AU - Krstić, Aleksandar AU - Popović, Jelena AU - Milivojević, Milena AU - Stevanović, Milena PY - 2010 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/407 AB - To understand more fully the structure and evolution of the SOX3 protein, we comparatively analyzed its orthologs in vertebrates. Since complex disorders are associated with human SOX3 polyalanine expansions, our investigation focused on both compositional and evolutionary analysis of various homopolymeric amino acid tracts observed in SOX3 orthologs. Our analysis revealed that the observed homopolymeric alanine, glycine, and proline tracts are mammal-specific, except for one polyglycine tract present in birds. Since it is likely that the SOX3 protein acquired additional roles in brain development in Eutheria, we might speculate that development of novel brain functions during the course of evolution was affected, at least in part, by such structural-functional changes in the SOX3 protein. PB - Springer/Plenum Publishers, New York T2 - Biochemical Genetics T1 - Comparative Analysis of SOX3 Protein Orthologs: Expansion of Homopolymeric Amino Acid Tracts During Vertebrate Evolution EP - 623 IS - 7-8 SP - 612 VL - 48 DO - 10.1007/s10528-010-9343-2 ER -
@article{ author = "Mojsin, Marija and Kovačević Grujičić, Nataša and Krstić, Aleksandar and Popović, Jelena and Milivojević, Milena and Stevanović, Milena", year = "2010", abstract = "To understand more fully the structure and evolution of the SOX3 protein, we comparatively analyzed its orthologs in vertebrates. Since complex disorders are associated with human SOX3 polyalanine expansions, our investigation focused on both compositional and evolutionary analysis of various homopolymeric amino acid tracts observed in SOX3 orthologs. Our analysis revealed that the observed homopolymeric alanine, glycine, and proline tracts are mammal-specific, except for one polyglycine tract present in birds. Since it is likely that the SOX3 protein acquired additional roles in brain development in Eutheria, we might speculate that development of novel brain functions during the course of evolution was affected, at least in part, by such structural-functional changes in the SOX3 protein.", publisher = "Springer/Plenum Publishers, New York", journal = "Biochemical Genetics", title = "Comparative Analysis of SOX3 Protein Orthologs: Expansion of Homopolymeric Amino Acid Tracts During Vertebrate Evolution", pages = "623-612", number = "7-8", volume = "48", doi = "10.1007/s10528-010-9343-2" }
Mojsin, M., Kovačević Grujičić, N., Krstić, A., Popović, J., Milivojević, M.,& Stevanović, M.. (2010). Comparative Analysis of SOX3 Protein Orthologs: Expansion of Homopolymeric Amino Acid Tracts During Vertebrate Evolution. in Biochemical Genetics Springer/Plenum Publishers, New York., 48(7-8), 612-623. https://doi.org/10.1007/s10528-010-9343-2
Mojsin M, Kovačević Grujičić N, Krstić A, Popović J, Milivojević M, Stevanović M. Comparative Analysis of SOX3 Protein Orthologs: Expansion of Homopolymeric Amino Acid Tracts During Vertebrate Evolution. in Biochemical Genetics. 2010;48(7-8):612-623. doi:10.1007/s10528-010-9343-2 .
Mojsin, Marija, Kovačević Grujičić, Nataša, Krstić, Aleksandar, Popović, Jelena, Milivojević, Milena, Stevanović, Milena, "Comparative Analysis of SOX3 Protein Orthologs: Expansion of Homopolymeric Amino Acid Tracts During Vertebrate Evolution" in Biochemical Genetics, 48, no. 7-8 (2010):612-623, https://doi.org/10.1007/s10528-010-9343-2 . .