Thrombophilia in Women with Pregnancy-Associated Complications: Fetal Loss and Pregnancy-Related Venous Thromboembolism
Само за регистроване кориснике
2010
Аутори
Kovač, MirjanaMitić, G.
Miković, Z.
Đorđević, Valentina
Savić, O.
Mandić, V.
Rakićević, Ljiljana
Antonijević, Nebojša
Radojković, Dragica
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Backgound/Aims: Existing data regarding the prevalence of thrombophilia in women with pregnancy complications are conflicting. Methods: To investigate the relationship between pregnancy-associated complications and the presence of thrombophilia, we studied the records of 453 women with pregnancy-associated complications. In 55 women, intrauterine fetal death ( fetus mortus in utero, FMU) after 20 weeks of gestation was recorded, in 231 two or more consecutive recurrent fetal losses (RFL) were recorded, while 167 had a venous thromboembolism (VTE) during one of their pregnancies. The control group consisted of 128 healthy women, with no previous history of thrombotic events or miscarriages. Results: In the FMU group we found 54.5% of women had thrombophilia, in the RFL group 38%, and in the VTE group 52.7%. The most frequent thrombophilia in the VTE group was the FV Leiden ( OR 17.9, 95% CI 4.2-75.9). The most frequent thrombophilia in the FMU group was the FII G20210A ( OR 7.09, 95% CI... 1.8-27.9). Statistical difference between RFL and the control group was observed only for FV Leiden ( OR 6.8, 95% CI 1.6-29.7). Conclusion: Thrombophilia was found to be considerably more common in women with pregnancy-associated complications in comparison with the women with normal pregnancies, most frequently in patients with VTE or FMU.
Кључне речи:
Venous thromboembolism, pregnancy related / Thrombophilia / Recurrent pregnancy lossИзвор:
Gynecologic and Obstetric Investigation, 2010, 69, 4, 233-238Издавач:
- Karger, Basel
Финансирање / пројекти:
- Структурални елементи генома у модулацији фенотипа (RS-MESTD-MPN2006-2010-143051)
DOI: 10.1159/000274012
ISSN: 0378-7346
PubMed: 20068329
WoS: 000274080600004
Scopus: 2-s2.0-73649083739
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Kovač, Mirjana AU - Mitić, G. AU - Miković, Z. AU - Đorđević, Valentina AU - Savić, O. AU - Mandić, V. AU - Rakićević, Ljiljana AU - Antonijević, Nebojša AU - Radojković, Dragica PY - 2010 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/410 AB - Backgound/Aims: Existing data regarding the prevalence of thrombophilia in women with pregnancy complications are conflicting. Methods: To investigate the relationship between pregnancy-associated complications and the presence of thrombophilia, we studied the records of 453 women with pregnancy-associated complications. In 55 women, intrauterine fetal death ( fetus mortus in utero, FMU) after 20 weeks of gestation was recorded, in 231 two or more consecutive recurrent fetal losses (RFL) were recorded, while 167 had a venous thromboembolism (VTE) during one of their pregnancies. The control group consisted of 128 healthy women, with no previous history of thrombotic events or miscarriages. Results: In the FMU group we found 54.5% of women had thrombophilia, in the RFL group 38%, and in the VTE group 52.7%. The most frequent thrombophilia in the VTE group was the FV Leiden ( OR 17.9, 95% CI 4.2-75.9). The most frequent thrombophilia in the FMU group was the FII G20210A ( OR 7.09, 95% CI 1.8-27.9). Statistical difference between RFL and the control group was observed only for FV Leiden ( OR 6.8, 95% CI 1.6-29.7). Conclusion: Thrombophilia was found to be considerably more common in women with pregnancy-associated complications in comparison with the women with normal pregnancies, most frequently in patients with VTE or FMU. PB - Karger, Basel T2 - Gynecologic and Obstetric Investigation T1 - Thrombophilia in Women with Pregnancy-Associated Complications: Fetal Loss and Pregnancy-Related Venous Thromboembolism EP - 238 IS - 4 SP - 233 VL - 69 DO - 10.1159/000274012 ER -
@article{ author = "Kovač, Mirjana and Mitić, G. and Miković, Z. and Đorđević, Valentina and Savić, O. and Mandić, V. and Rakićević, Ljiljana and Antonijević, Nebojša and Radojković, Dragica", year = "2010", abstract = "Backgound/Aims: Existing data regarding the prevalence of thrombophilia in women with pregnancy complications are conflicting. Methods: To investigate the relationship between pregnancy-associated complications and the presence of thrombophilia, we studied the records of 453 women with pregnancy-associated complications. In 55 women, intrauterine fetal death ( fetus mortus in utero, FMU) after 20 weeks of gestation was recorded, in 231 two or more consecutive recurrent fetal losses (RFL) were recorded, while 167 had a venous thromboembolism (VTE) during one of their pregnancies. The control group consisted of 128 healthy women, with no previous history of thrombotic events or miscarriages. Results: In the FMU group we found 54.5% of women had thrombophilia, in the RFL group 38%, and in the VTE group 52.7%. The most frequent thrombophilia in the VTE group was the FV Leiden ( OR 17.9, 95% CI 4.2-75.9). The most frequent thrombophilia in the FMU group was the FII G20210A ( OR 7.09, 95% CI 1.8-27.9). Statistical difference between RFL and the control group was observed only for FV Leiden ( OR 6.8, 95% CI 1.6-29.7). Conclusion: Thrombophilia was found to be considerably more common in women with pregnancy-associated complications in comparison with the women with normal pregnancies, most frequently in patients with VTE or FMU.", publisher = "Karger, Basel", journal = "Gynecologic and Obstetric Investigation", title = "Thrombophilia in Women with Pregnancy-Associated Complications: Fetal Loss and Pregnancy-Related Venous Thromboembolism", pages = "238-233", number = "4", volume = "69", doi = "10.1159/000274012" }
Kovač, M., Mitić, G., Miković, Z., Đorđević, V., Savić, O., Mandić, V., Rakićević, L., Antonijević, N.,& Radojković, D.. (2010). Thrombophilia in Women with Pregnancy-Associated Complications: Fetal Loss and Pregnancy-Related Venous Thromboembolism. in Gynecologic and Obstetric Investigation Karger, Basel., 69(4), 233-238. https://doi.org/10.1159/000274012
Kovač M, Mitić G, Miković Z, Đorđević V, Savić O, Mandić V, Rakićević L, Antonijević N, Radojković D. Thrombophilia in Women with Pregnancy-Associated Complications: Fetal Loss and Pregnancy-Related Venous Thromboembolism. in Gynecologic and Obstetric Investigation. 2010;69(4):233-238. doi:10.1159/000274012 .
Kovač, Mirjana, Mitić, G., Miković, Z., Đorđević, Valentina, Savić, O., Mandić, V., Rakićević, Ljiljana, Antonijević, Nebojša, Radojković, Dragica, "Thrombophilia in Women with Pregnancy-Associated Complications: Fetal Loss and Pregnancy-Related Venous Thromboembolism" in Gynecologic and Obstetric Investigation, 69, no. 4 (2010):233-238, https://doi.org/10.1159/000274012 . .