Type and Location of Venous Thromboembolism in Carriers of Factor V Leiden or Prothrombin G20210A Mutation Versus Patients With No Mutation
2010
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Аутори
Kovač, MirjanaMitić, Gorana
Miković, Zeljko
Antonijević, Nebojša
Đorđević, Valentina
Miković, Danijela
Mandić, Vesna
Rakićević, Ljiljana
Radojković, Dragica
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Factor V Leiden (FVLeiden) and prothrombin G20210A are the most common genetic causes of thrombophilia and established risk factors for different clinical manifestations of venous thromboembolism (VTE). This study investigated whether the clinical manifestation of VTE, the extension of deep vein thrombosis (DVT) and the presence of transient risk factors at the time of the first VTE, differed among patients with mutations (97 with FVLeiden; 33 with prothrombin G20210A) and in 109 patients without thrombophilia. Isolated pulmonary embolism (PE) was less prevalent in patients with FVLeiden (6%) and no thrombophilia (6%) than in those with prothrombin G20210A (15%). No difference was found in the incidence of distal DVT. Regarding the extension of proximal DVT, the lowest incidence for isolated popliteal vein and the highest for iliofemoral vein were observed in patients with prothrombin G20210A. No difference was observed between groups of patients with or without thrombophilia by unprov...oked VTE. The pregnancy/puerperium was the most prevalent risk factor in carriers of prothrombin G20210A. Among FVLeiden carriers, the most prevalent risk factor was surgery, and in patients without thrombophilia, it was trauma (P lt .05). Thrombosis of the upper limb was more frequent in a group without thrombophilia than in patients with mutations (P lt .01). Transverse sinus venous thrombosis was present only in patients with prothrombin G20210A. Carriers of prothrombin G20210A have an increased risk of developing isolated PE and more severe clinical manifestations than those with FVLeiden or without thrombophilia.
Кључне речи:
venous thromboembolism / prothrombin G20210A / isolated PE / factor V Leiden / clinical manifestationsИзвор:
Clinical and Applied Thrombosis-Hemostasis, 2010, 16, 1, 66-70Издавач:
- Sage Publications Inc, Thousand Oaks
Финансирање / пројекти:
- Структурални елементи генома у модулацији фенотипа (RS-MESTD-MPN2006-2010-143051)
DOI: 10.1177/1076029608320721
ISSN: 1076-0296
PubMed: 18796457
WoS: 000274087000009
Scopus: 2-s2.0-76049116291
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Kovač, Mirjana AU - Mitić, Gorana AU - Miković, Zeljko AU - Antonijević, Nebojša AU - Đorđević, Valentina AU - Miković, Danijela AU - Mandić, Vesna AU - Rakićević, Ljiljana AU - Radojković, Dragica PY - 2010 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/412 AB - Factor V Leiden (FVLeiden) and prothrombin G20210A are the most common genetic causes of thrombophilia and established risk factors for different clinical manifestations of venous thromboembolism (VTE). This study investigated whether the clinical manifestation of VTE, the extension of deep vein thrombosis (DVT) and the presence of transient risk factors at the time of the first VTE, differed among patients with mutations (97 with FVLeiden; 33 with prothrombin G20210A) and in 109 patients without thrombophilia. Isolated pulmonary embolism (PE) was less prevalent in patients with FVLeiden (6%) and no thrombophilia (6%) than in those with prothrombin G20210A (15%). No difference was found in the incidence of distal DVT. Regarding the extension of proximal DVT, the lowest incidence for isolated popliteal vein and the highest for iliofemoral vein were observed in patients with prothrombin G20210A. No difference was observed between groups of patients with or without thrombophilia by unprovoked VTE. The pregnancy/puerperium was the most prevalent risk factor in carriers of prothrombin G20210A. Among FVLeiden carriers, the most prevalent risk factor was surgery, and in patients without thrombophilia, it was trauma (P lt .05). Thrombosis of the upper limb was more frequent in a group without thrombophilia than in patients with mutations (P lt .01). Transverse sinus venous thrombosis was present only in patients with prothrombin G20210A. Carriers of prothrombin G20210A have an increased risk of developing isolated PE and more severe clinical manifestations than those with FVLeiden or without thrombophilia. PB - Sage Publications Inc, Thousand Oaks T2 - Clinical and Applied Thrombosis-Hemostasis T1 - Type and Location of Venous Thromboembolism in Carriers of Factor V Leiden or Prothrombin G20210A Mutation Versus Patients With No Mutation EP - 70 IS - 1 SP - 66 VL - 16 DO - 10.1177/1076029608320721 ER -
@article{ author = "Kovač, Mirjana and Mitić, Gorana and Miković, Zeljko and Antonijević, Nebojša and Đorđević, Valentina and Miković, Danijela and Mandić, Vesna and Rakićević, Ljiljana and Radojković, Dragica", year = "2010", abstract = "Factor V Leiden (FVLeiden) and prothrombin G20210A are the most common genetic causes of thrombophilia and established risk factors for different clinical manifestations of venous thromboembolism (VTE). This study investigated whether the clinical manifestation of VTE, the extension of deep vein thrombosis (DVT) and the presence of transient risk factors at the time of the first VTE, differed among patients with mutations (97 with FVLeiden; 33 with prothrombin G20210A) and in 109 patients without thrombophilia. Isolated pulmonary embolism (PE) was less prevalent in patients with FVLeiden (6%) and no thrombophilia (6%) than in those with prothrombin G20210A (15%). No difference was found in the incidence of distal DVT. Regarding the extension of proximal DVT, the lowest incidence for isolated popliteal vein and the highest for iliofemoral vein were observed in patients with prothrombin G20210A. No difference was observed between groups of patients with or without thrombophilia by unprovoked VTE. The pregnancy/puerperium was the most prevalent risk factor in carriers of prothrombin G20210A. Among FVLeiden carriers, the most prevalent risk factor was surgery, and in patients without thrombophilia, it was trauma (P lt .05). Thrombosis of the upper limb was more frequent in a group without thrombophilia than in patients with mutations (P lt .01). Transverse sinus venous thrombosis was present only in patients with prothrombin G20210A. Carriers of prothrombin G20210A have an increased risk of developing isolated PE and more severe clinical manifestations than those with FVLeiden or without thrombophilia.", publisher = "Sage Publications Inc, Thousand Oaks", journal = "Clinical and Applied Thrombosis-Hemostasis", title = "Type and Location of Venous Thromboembolism in Carriers of Factor V Leiden or Prothrombin G20210A Mutation Versus Patients With No Mutation", pages = "70-66", number = "1", volume = "16", doi = "10.1177/1076029608320721" }
Kovač, M., Mitić, G., Miković, Z., Antonijević, N., Đorđević, V., Miković, D., Mandić, V., Rakićević, L.,& Radojković, D.. (2010). Type and Location of Venous Thromboembolism in Carriers of Factor V Leiden or Prothrombin G20210A Mutation Versus Patients With No Mutation. in Clinical and Applied Thrombosis-Hemostasis Sage Publications Inc, Thousand Oaks., 16(1), 66-70. https://doi.org/10.1177/1076029608320721
Kovač M, Mitić G, Miković Z, Antonijević N, Đorđević V, Miković D, Mandić V, Rakićević L, Radojković D. Type and Location of Venous Thromboembolism in Carriers of Factor V Leiden or Prothrombin G20210A Mutation Versus Patients With No Mutation. in Clinical and Applied Thrombosis-Hemostasis. 2010;16(1):66-70. doi:10.1177/1076029608320721 .
Kovač, Mirjana, Mitić, Gorana, Miković, Zeljko, Antonijević, Nebojša, Đorđević, Valentina, Miković, Danijela, Mandić, Vesna, Rakićević, Ljiljana, Radojković, Dragica, "Type and Location of Venous Thromboembolism in Carriers of Factor V Leiden or Prothrombin G20210A Mutation Versus Patients With No Mutation" in Clinical and Applied Thrombosis-Hemostasis, 16, no. 1 (2010):66-70, https://doi.org/10.1177/1076029608320721 . .