The use of D-dimer with new cutoff can be useful in diagnosis of venous thromboembolism in pregnancy
Samo za registrovane korisnike
2010
Autori
Kovač, MirjanaMiković, Zeljko
Rakićević, Ljiljana
Srzentić, Snežana
Mandić, Vesna
Đorđević, Valentina
Radojković, Dragica
Elezović, Ivo
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Objective: D-dimer testing has an important role in the exclusion of acute venous thromboembolism (VTE) in the nonpregnant population. Establishing D-dimers role in the diagnosis of VTE in pregnancy is hampered because of the substantial increase of D-dimer throughout gestational age. Study design: In a prospective study we followed 89 healthy pregnant women to establish the reference range of D-dimer for each trimester. D-dimer testing was also performed in 12 women with clinical suspicion of VTE and their results were compared with the established new reference range of D-dimer, and with the recorded ultrasound findings. Results: In the first trimester, 84% women from reference group had normal D-dimer, in the second 33%, and by the third trimester only 1%, which suggests that D-dimer has no practical diagnostic use in ruling out VTE if the threshold of 230 ng/mL for abnormal is used. All pregnant women with thrombosis who had positive ultrasound findings also had statistically signi...ficant elevation of the D-dimer level, considering the established reference range of the corresponding trimester. We found 100% sensitivity of D-dimer test. A women developed thrombosis in the first trimester had 6.7-7.6 time higher level of D-dimer than the mean value in the reference group, and in the third trimester thrombotic women had 2.0-3.8 time higher level of D-dimer, p lt 0.0001. Conclusion: D-dimer test with the new threshold for: the first of 286, the second of 457 and the third trimester of 644 ng/mL can be useful in diagnosis of pregnancy related VTE.
Ključne reči:
thromboembolism / Pregnancy related venous / D-dimer testingIzvor:
European Journal of Obstetrics & Gynecology and Reproductive Biology, 2010, 148, 1, 27-30Izdavač:
- Elsevier, Amsterdam
Finansiranje / projekti:
- Strukturalni elementi genoma u modulaciji fenotipa (RS-MESTD-MPN2006-2010-143051)
DOI: 10.1016/j.ejogrb.2009.09.005
ISSN: 0301-2115
PubMed: 19804940
WoS: 000274103500005
Scopus: 2-s2.0-72149129472
Kolekcije
Institucija/grupa
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Kovač, Mirjana AU - Miković, Zeljko AU - Rakićević, Ljiljana AU - Srzentić, Snežana AU - Mandić, Vesna AU - Đorđević, Valentina AU - Radojković, Dragica AU - Elezović, Ivo PY - 2010 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/413 AB - Objective: D-dimer testing has an important role in the exclusion of acute venous thromboembolism (VTE) in the nonpregnant population. Establishing D-dimers role in the diagnosis of VTE in pregnancy is hampered because of the substantial increase of D-dimer throughout gestational age. Study design: In a prospective study we followed 89 healthy pregnant women to establish the reference range of D-dimer for each trimester. D-dimer testing was also performed in 12 women with clinical suspicion of VTE and their results were compared with the established new reference range of D-dimer, and with the recorded ultrasound findings. Results: In the first trimester, 84% women from reference group had normal D-dimer, in the second 33%, and by the third trimester only 1%, which suggests that D-dimer has no practical diagnostic use in ruling out VTE if the threshold of 230 ng/mL for abnormal is used. All pregnant women with thrombosis who had positive ultrasound findings also had statistically significant elevation of the D-dimer level, considering the established reference range of the corresponding trimester. We found 100% sensitivity of D-dimer test. A women developed thrombosis in the first trimester had 6.7-7.6 time higher level of D-dimer than the mean value in the reference group, and in the third trimester thrombotic women had 2.0-3.8 time higher level of D-dimer, p lt 0.0001. Conclusion: D-dimer test with the new threshold for: the first of 286, the second of 457 and the third trimester of 644 ng/mL can be useful in diagnosis of pregnancy related VTE. PB - Elsevier, Amsterdam T2 - European Journal of Obstetrics & Gynecology and Reproductive Biology T1 - The use of D-dimer with new cutoff can be useful in diagnosis of venous thromboembolism in pregnancy EP - 30 IS - 1 SP - 27 VL - 148 DO - 10.1016/j.ejogrb.2009.09.005 ER -
@article{ author = "Kovač, Mirjana and Miković, Zeljko and Rakićević, Ljiljana and Srzentić, Snežana and Mandić, Vesna and Đorđević, Valentina and Radojković, Dragica and Elezović, Ivo", year = "2010", abstract = "Objective: D-dimer testing has an important role in the exclusion of acute venous thromboembolism (VTE) in the nonpregnant population. Establishing D-dimers role in the diagnosis of VTE in pregnancy is hampered because of the substantial increase of D-dimer throughout gestational age. Study design: In a prospective study we followed 89 healthy pregnant women to establish the reference range of D-dimer for each trimester. D-dimer testing was also performed in 12 women with clinical suspicion of VTE and their results were compared with the established new reference range of D-dimer, and with the recorded ultrasound findings. Results: In the first trimester, 84% women from reference group had normal D-dimer, in the second 33%, and by the third trimester only 1%, which suggests that D-dimer has no practical diagnostic use in ruling out VTE if the threshold of 230 ng/mL for abnormal is used. All pregnant women with thrombosis who had positive ultrasound findings also had statistically significant elevation of the D-dimer level, considering the established reference range of the corresponding trimester. We found 100% sensitivity of D-dimer test. A women developed thrombosis in the first trimester had 6.7-7.6 time higher level of D-dimer than the mean value in the reference group, and in the third trimester thrombotic women had 2.0-3.8 time higher level of D-dimer, p lt 0.0001. Conclusion: D-dimer test with the new threshold for: the first of 286, the second of 457 and the third trimester of 644 ng/mL can be useful in diagnosis of pregnancy related VTE.", publisher = "Elsevier, Amsterdam", journal = "European Journal of Obstetrics & Gynecology and Reproductive Biology", title = "The use of D-dimer with new cutoff can be useful in diagnosis of venous thromboembolism in pregnancy", pages = "30-27", number = "1", volume = "148", doi = "10.1016/j.ejogrb.2009.09.005" }
Kovač, M., Miković, Z., Rakićević, L., Srzentić, S., Mandić, V., Đorđević, V., Radojković, D.,& Elezović, I.. (2010). The use of D-dimer with new cutoff can be useful in diagnosis of venous thromboembolism in pregnancy. in European Journal of Obstetrics & Gynecology and Reproductive Biology Elsevier, Amsterdam., 148(1), 27-30. https://doi.org/10.1016/j.ejogrb.2009.09.005
Kovač M, Miković Z, Rakićević L, Srzentić S, Mandić V, Đorđević V, Radojković D, Elezović I. The use of D-dimer with new cutoff can be useful in diagnosis of venous thromboembolism in pregnancy. in European Journal of Obstetrics & Gynecology and Reproductive Biology. 2010;148(1):27-30. doi:10.1016/j.ejogrb.2009.09.005 .
Kovač, Mirjana, Miković, Zeljko, Rakićević, Ljiljana, Srzentić, Snežana, Mandić, Vesna, Đorđević, Valentina, Radojković, Dragica, Elezović, Ivo, "The use of D-dimer with new cutoff can be useful in diagnosis of venous thromboembolism in pregnancy" in European Journal of Obstetrics & Gynecology and Reproductive Biology, 148, no. 1 (2010):27-30, https://doi.org/10.1016/j.ejogrb.2009.09.005 . .