Clinical features of the most common fusion genes in childhood acute lymphoblastic leukemia
Само за регистроване кориснике
2010
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Contemporary protocols ensure high-remission rate and long-term free survival in children with acute lymphoblastic leukemia (ALL), but small percentage of patients is still incurable. Molecular genetic methods helped to establish submicroscopic classification as well as minimal residual disease follow-up, considered to be responsible for relapse. Our study enrolled 70 pediatric patients with de novo ALL, analyzed using reverse transcriptase-polymerase chain reaction for the presence of four major risk-stratifying translocations (BCR/ABL, MLL/AF4, TEL/AML1, and E2A/PBX1). Bone marrow samples were collected at diagnosis, at the end of induction phase, and after intensive chemotherapy with the aim to establish the correlation between chromosomal aberration, clinical features, and treatment response. Presenting the results of this study, we offer another evidence of variable incidence and clinical characteristics of ALL subtypes.
Кључне речи:
Therapy response / Pediatric acute lymphoblastic leukemia / Fusion genes / Clinical featuresИзвор:
Medical Oncology, 2010, 27, 2, 449-453Издавач:
- Humana Press Inc, Totowa
Финансирање / пројекти:
- Структурални елементи генома у модулацији фенотипа (RS-MESTD-MPN2006-2010-143051)
DOI: 10.1007/s12032-009-9232-x
ISSN: 1357-0560
PubMed: 19488866
WoS: 000277203200044
Scopus: 2-s2.0-77956902000
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Lazić, J. AU - Tošić, Nataša AU - Dokmanović, Lidija AU - Krstovski, N. AU - Rodić, P. AU - Pavlović, Sonja AU - Janić, D. PY - 2010 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/423 AB - Contemporary protocols ensure high-remission rate and long-term free survival in children with acute lymphoblastic leukemia (ALL), but small percentage of patients is still incurable. Molecular genetic methods helped to establish submicroscopic classification as well as minimal residual disease follow-up, considered to be responsible for relapse. Our study enrolled 70 pediatric patients with de novo ALL, analyzed using reverse transcriptase-polymerase chain reaction for the presence of four major risk-stratifying translocations (BCR/ABL, MLL/AF4, TEL/AML1, and E2A/PBX1). Bone marrow samples were collected at diagnosis, at the end of induction phase, and after intensive chemotherapy with the aim to establish the correlation between chromosomal aberration, clinical features, and treatment response. Presenting the results of this study, we offer another evidence of variable incidence and clinical characteristics of ALL subtypes. PB - Humana Press Inc, Totowa T2 - Medical Oncology T1 - Clinical features of the most common fusion genes in childhood acute lymphoblastic leukemia EP - 453 IS - 2 SP - 449 VL - 27 DO - 10.1007/s12032-009-9232-x ER -
@article{ author = "Lazić, J. and Tošić, Nataša and Dokmanović, Lidija and Krstovski, N. and Rodić, P. and Pavlović, Sonja and Janić, D.", year = "2010", abstract = "Contemporary protocols ensure high-remission rate and long-term free survival in children with acute lymphoblastic leukemia (ALL), but small percentage of patients is still incurable. Molecular genetic methods helped to establish submicroscopic classification as well as minimal residual disease follow-up, considered to be responsible for relapse. Our study enrolled 70 pediatric patients with de novo ALL, analyzed using reverse transcriptase-polymerase chain reaction for the presence of four major risk-stratifying translocations (BCR/ABL, MLL/AF4, TEL/AML1, and E2A/PBX1). Bone marrow samples were collected at diagnosis, at the end of induction phase, and after intensive chemotherapy with the aim to establish the correlation between chromosomal aberration, clinical features, and treatment response. Presenting the results of this study, we offer another evidence of variable incidence and clinical characteristics of ALL subtypes.", publisher = "Humana Press Inc, Totowa", journal = "Medical Oncology", title = "Clinical features of the most common fusion genes in childhood acute lymphoblastic leukemia", pages = "453-449", number = "2", volume = "27", doi = "10.1007/s12032-009-9232-x" }
Lazić, J., Tošić, N., Dokmanović, L., Krstovski, N., Rodić, P., Pavlović, S.,& Janić, D.. (2010). Clinical features of the most common fusion genes in childhood acute lymphoblastic leukemia. in Medical Oncology Humana Press Inc, Totowa., 27(2), 449-453. https://doi.org/10.1007/s12032-009-9232-x
Lazić J, Tošić N, Dokmanović L, Krstovski N, Rodić P, Pavlović S, Janić D. Clinical features of the most common fusion genes in childhood acute lymphoblastic leukemia. in Medical Oncology. 2010;27(2):449-453. doi:10.1007/s12032-009-9232-x .
Lazić, J., Tošić, Nataša, Dokmanović, Lidija, Krstovski, N., Rodić, P., Pavlović, Sonja, Janić, D., "Clinical features of the most common fusion genes in childhood acute lymphoblastic leukemia" in Medical Oncology, 27, no. 2 (2010):449-453, https://doi.org/10.1007/s12032-009-9232-x . .