Novel transcriptional regulatory element in the phenylalanine hydroxylase gene intron 8
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2010
Authors
Stojiljković, MajaZukić, Branka
Tošić, Nataša
Karan-Đurašević, Teodora
Spasovski, Vesna
Nikčević, Gordana
Pavlović, Sonja
Article (Published version)
Metadata
Show full item recordAbstract
We present the first transcriptional regulatory element found in a PAH gene intron. The element is located in the PAH gene intron 8, acts as an enhancer specifically in the hepatoma cell line, and binds GATA-1 transcription factor. Herein the presented data could unlock a new area for the analysis of PAH gene expression and could contribute to refining genotype-phenotype correlation.
Keywords:
Transcription / Phenylketonuria / Phenylalanine hydroxylase gene / Intron / GATA-1 / EnhancerSource:
Molecular Genetics and Metabolism, 2010, 101, 1, 81-83Publisher:
- Academic Press Inc Elsevier Science, San Diego
Funding / projects:
- Strukturalni elementi genoma u modulaciji fenotipa (RS-MESTD-MPN2006-2010-143051)
- Izučavanje regulacije ekspresije i funkcije humanih SOX gena (RS-MESTD-MPN2006-2010-143028)
DOI: 10.1016/j.ymgme.2010.05.014
ISSN: 1096-7192
PubMed: 20599406
WoS: 000281346500012
Scopus: 2-s2.0-77955664329
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Institution/Community
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Stojiljković, Maja AU - Zukić, Branka AU - Tošić, Nataša AU - Karan-Đurašević, Teodora AU - Spasovski, Vesna AU - Nikčević, Gordana AU - Pavlović, Sonja PY - 2010 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/435 AB - We present the first transcriptional regulatory element found in a PAH gene intron. The element is located in the PAH gene intron 8, acts as an enhancer specifically in the hepatoma cell line, and binds GATA-1 transcription factor. Herein the presented data could unlock a new area for the analysis of PAH gene expression and could contribute to refining genotype-phenotype correlation. PB - Academic Press Inc Elsevier Science, San Diego T2 - Molecular Genetics and Metabolism T1 - Novel transcriptional regulatory element in the phenylalanine hydroxylase gene intron 8 EP - 83 IS - 1 SP - 81 VL - 101 DO - 10.1016/j.ymgme.2010.05.014 ER -
@article{ author = "Stojiljković, Maja and Zukić, Branka and Tošić, Nataša and Karan-Đurašević, Teodora and Spasovski, Vesna and Nikčević, Gordana and Pavlović, Sonja", year = "2010", abstract = "We present the first transcriptional regulatory element found in a PAH gene intron. The element is located in the PAH gene intron 8, acts as an enhancer specifically in the hepatoma cell line, and binds GATA-1 transcription factor. Herein the presented data could unlock a new area for the analysis of PAH gene expression and could contribute to refining genotype-phenotype correlation.", publisher = "Academic Press Inc Elsevier Science, San Diego", journal = "Molecular Genetics and Metabolism", title = "Novel transcriptional regulatory element in the phenylalanine hydroxylase gene intron 8", pages = "83-81", number = "1", volume = "101", doi = "10.1016/j.ymgme.2010.05.014" }
Stojiljković, M., Zukić, B., Tošić, N., Karan-Đurašević, T., Spasovski, V., Nikčević, G.,& Pavlović, S.. (2010). Novel transcriptional regulatory element in the phenylalanine hydroxylase gene intron 8. in Molecular Genetics and Metabolism Academic Press Inc Elsevier Science, San Diego., 101(1), 81-83. https://doi.org/10.1016/j.ymgme.2010.05.014
Stojiljković M, Zukić B, Tošić N, Karan-Đurašević T, Spasovski V, Nikčević G, Pavlović S. Novel transcriptional regulatory element in the phenylalanine hydroxylase gene intron 8. in Molecular Genetics and Metabolism. 2010;101(1):81-83. doi:10.1016/j.ymgme.2010.05.014 .
Stojiljković, Maja, Zukić, Branka, Tošić, Nataša, Karan-Đurašević, Teodora, Spasovski, Vesna, Nikčević, Gordana, Pavlović, Sonja, "Novel transcriptional regulatory element in the phenylalanine hydroxylase gene intron 8" in Molecular Genetics and Metabolism, 101, no. 1 (2010):81-83, https://doi.org/10.1016/j.ymgme.2010.05.014 . .