+1040 C/T polymorphism in coding region of thrombin-activatable fibrinolysis inhibitor gene and the risk of idiopathic recurrent fetal loss
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2010
Authors
Pruner, IvaĐorđević, Valentina
Miljić, Predrag
Kovač, Mirjana
Antonijević, Nebojša
Rakićević, Ljiljana
Radojković, Dragica
Article (Published version)
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Recurrent fetal loss (RFL) is common health problem affecting up to 5% of women of reproductive age. It has been shown that plasma thrombin-activatable fibrinolysis inhibitor (TAFI) concentrations increase during pregnancy and return to baseline levels soon after delivery. The +1040C/T single nucleotide polymorphism in coding region of TAFI gene is associated with TAFI blood levels. The aim of our study was to investigate the relationship between +1040C/T polymorphism in TAFI gene and idiopathic RFL. Study was carried out in a group of 120 women (61 controls and 59 women with idiopathic RFL). The R1040C/T polymorphism was detected by restriction fragment length polymorphism PCR. Increased frequency of +1040T/T genotype was observed in a study group, but without statistically significant difference. Carriers of T/T genotype have increased risk of fetal loss by 1.23-fold, compared with carriers of C/C (95% CI 0.462-3.277; P=0.7) and 1.34-fold compared with carriers of C/T genotype (95% C...I 0.501-3.601; P=0.6). C allele is associated with reduced risk of recurrent fetal loss compared with T allele (OR 0.91; 95% CI 0.545-1.533; P=0.7). In conclusion, we observed increased frequency of +1040T/T genotype in a patient group, suggesting that this genotype could be potential risk factor for idiopathic RFL. Further investigation should be carried out in order to establish the role of this polymorphism in the etiology of idiopathic recurrent miscarriages. Blood Coagul Fibrinolysis 21: 679-682
Keywords:
thrombin-activatable fibrinolysis inhibitor / recurrent fetal loss / +1040C/T polymorphismSource:
Blood Coagulation & Fibrinolysis, 2010, 21, 7, 679-682Publisher:
- Lippincott Williams & Wilkins, Philadelphia
Funding / projects:
- Strukturalni elementi genoma u modulaciji fenotipa (RS-MESTD-MPN2006-2010-143051)
DOI: 10.1097/MBC.0b013e32833e426d
ISSN: 0957-5235
PubMed: 20729722
WoS: 000282483500011
Scopus: 2-s2.0-77958155397
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Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Pruner, Iva AU - Đorđević, Valentina AU - Miljić, Predrag AU - Kovač, Mirjana AU - Antonijević, Nebojša AU - Rakićević, Ljiljana AU - Radojković, Dragica PY - 2010 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/441 AB - Recurrent fetal loss (RFL) is common health problem affecting up to 5% of women of reproductive age. It has been shown that plasma thrombin-activatable fibrinolysis inhibitor (TAFI) concentrations increase during pregnancy and return to baseline levels soon after delivery. The +1040C/T single nucleotide polymorphism in coding region of TAFI gene is associated with TAFI blood levels. The aim of our study was to investigate the relationship between +1040C/T polymorphism in TAFI gene and idiopathic RFL. Study was carried out in a group of 120 women (61 controls and 59 women with idiopathic RFL). The R1040C/T polymorphism was detected by restriction fragment length polymorphism PCR. Increased frequency of +1040T/T genotype was observed in a study group, but without statistically significant difference. Carriers of T/T genotype have increased risk of fetal loss by 1.23-fold, compared with carriers of C/C (95% CI 0.462-3.277; P=0.7) and 1.34-fold compared with carriers of C/T genotype (95% CI 0.501-3.601; P=0.6). C allele is associated with reduced risk of recurrent fetal loss compared with T allele (OR 0.91; 95% CI 0.545-1.533; P=0.7). In conclusion, we observed increased frequency of +1040T/T genotype in a patient group, suggesting that this genotype could be potential risk factor for idiopathic RFL. Further investigation should be carried out in order to establish the role of this polymorphism in the etiology of idiopathic recurrent miscarriages. Blood Coagul Fibrinolysis 21: 679-682 PB - Lippincott Williams & Wilkins, Philadelphia T2 - Blood Coagulation & Fibrinolysis T1 - +1040 C/T polymorphism in coding region of thrombin-activatable fibrinolysis inhibitor gene and the risk of idiopathic recurrent fetal loss EP - 682 IS - 7 SP - 679 VL - 21 DO - 10.1097/MBC.0b013e32833e426d ER -
@article{ author = "Pruner, Iva and Đorđević, Valentina and Miljić, Predrag and Kovač, Mirjana and Antonijević, Nebojša and Rakićević, Ljiljana and Radojković, Dragica", year = "2010", abstract = "Recurrent fetal loss (RFL) is common health problem affecting up to 5% of women of reproductive age. It has been shown that plasma thrombin-activatable fibrinolysis inhibitor (TAFI) concentrations increase during pregnancy and return to baseline levels soon after delivery. The +1040C/T single nucleotide polymorphism in coding region of TAFI gene is associated with TAFI blood levels. The aim of our study was to investigate the relationship between +1040C/T polymorphism in TAFI gene and idiopathic RFL. Study was carried out in a group of 120 women (61 controls and 59 women with idiopathic RFL). The R1040C/T polymorphism was detected by restriction fragment length polymorphism PCR. Increased frequency of +1040T/T genotype was observed in a study group, but without statistically significant difference. Carriers of T/T genotype have increased risk of fetal loss by 1.23-fold, compared with carriers of C/C (95% CI 0.462-3.277; P=0.7) and 1.34-fold compared with carriers of C/T genotype (95% CI 0.501-3.601; P=0.6). C allele is associated with reduced risk of recurrent fetal loss compared with T allele (OR 0.91; 95% CI 0.545-1.533; P=0.7). In conclusion, we observed increased frequency of +1040T/T genotype in a patient group, suggesting that this genotype could be potential risk factor for idiopathic RFL. Further investigation should be carried out in order to establish the role of this polymorphism in the etiology of idiopathic recurrent miscarriages. Blood Coagul Fibrinolysis 21: 679-682", publisher = "Lippincott Williams & Wilkins, Philadelphia", journal = "Blood Coagulation & Fibrinolysis", title = "+1040 C/T polymorphism in coding region of thrombin-activatable fibrinolysis inhibitor gene and the risk of idiopathic recurrent fetal loss", pages = "682-679", number = "7", volume = "21", doi = "10.1097/MBC.0b013e32833e426d" }
Pruner, I., Đorđević, V., Miljić, P., Kovač, M., Antonijević, N., Rakićević, L.,& Radojković, D.. (2010). +1040 C/T polymorphism in coding region of thrombin-activatable fibrinolysis inhibitor gene and the risk of idiopathic recurrent fetal loss. in Blood Coagulation & Fibrinolysis Lippincott Williams & Wilkins, Philadelphia., 21(7), 679-682. https://doi.org/10.1097/MBC.0b013e32833e426d
Pruner I, Đorđević V, Miljić P, Kovač M, Antonijević N, Rakićević L, Radojković D. +1040 C/T polymorphism in coding region of thrombin-activatable fibrinolysis inhibitor gene and the risk of idiopathic recurrent fetal loss. in Blood Coagulation & Fibrinolysis. 2010;21(7):679-682. doi:10.1097/MBC.0b013e32833e426d .
Pruner, Iva, Đorđević, Valentina, Miljić, Predrag, Kovač, Mirjana, Antonijević, Nebojša, Rakićević, Ljiljana, Radojković, Dragica, "+1040 C/T polymorphism in coding region of thrombin-activatable fibrinolysis inhibitor gene and the risk of idiopathic recurrent fetal loss" in Blood Coagulation & Fibrinolysis, 21, no. 7 (2010):679-682, https://doi.org/10.1097/MBC.0b013e32833e426d . .