Uloga sistema FasR/FasL u patogenezi mijeloproliferativnih neoplazija
The role of FasR/FasL system in pathogenesis of myeloprolyferative neoplasms
2010
Authors
Spasovski, VesnaTošić, Nataša
Kostić, Tatjana
Zukić, Branka
Stojiljković, Maja
Čolović, Milica
Pavlović, Sonja
Article (Published version)
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Mijeloproliferativne neoplazije (MPN) su hematološki maligniteti koji se karakterišu nekontrolisanom ćelijskom proliferacijom i poremećajem u procesu apoptoze. Sistem FasR/FasL je uključen u kontrolu apoptoze u različitim tipovima ćelija. U ovom radu je izučavana uloga sistema FasR/FasL u patogenezi mijeloproliferativnih neoplazija. Upoređena je ekspresija FasR i FasL između pacijenata sa MPN (24) i zdravih kontrola korišćenjem metode 'real-time' PCR. Detektovana je povećana ekspresija FasR kod pacijenata sa MPN. Nije utvrđena razlika u ekspresiji FasL. Mutacija B617F u JAK2 genu, karakteristična za MPN, je nađena kod 13 od 24 pacijenta. Pokazano je da ekspresija FasR i FasL nije povezana sa prisustvom B617F JAK2 mutacije.
Myeloproliferative neoplasms (MPN) are hematological malignancies characterized by uncontrolled cell proliferation and impaired apoptosis. The FasR/FasL system is involved in the control of apoptosis in different cell types. Here we have investigated the role of FasR/FasL in the pathogenesis of MPNs. We compared FasR/FasL expression between MPN patients (24) and healthy individuals using the real-time PCR assay. We found an increase of FasR expression in MPN patients. No difference was detected in FasL expression. Mutation V617F in the JAK2 gene, a hallmark of MPN, was detected in 13/24 patients. We found that neither FasR nor FasL expression were related to the presence of JAK2 V617F mutation.
Keywords:
Myeloproliferative neoplasms / JAK2 V617F mutation / FasR/FasLSource:
Archives of Biological Sciences, 2010, 62, 2, 223-230Publisher:
- Srpsko biološko društvo, Beograd, i dr.
Funding / projects:
- Molekularno genetski markeri klonskog preobražaja matičnih ćelija hematopoeze (RS-MESTD-MPN2006-2010-145061)
DOI: 10.2298/ABS1002223S
ISSN: 0354-4664
WoS: 000280017400003
Scopus: 2-s2.0-77955158292
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Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Spasovski, Vesna AU - Tošić, Nataša AU - Kostić, Tatjana AU - Zukić, Branka AU - Stojiljković, Maja AU - Čolović, Milica AU - Pavlović, Sonja PY - 2010 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/450 AB - Mijeloproliferativne neoplazije (MPN) su hematološki maligniteti koji se karakterišu nekontrolisanom ćelijskom proliferacijom i poremećajem u procesu apoptoze. Sistem FasR/FasL je uključen u kontrolu apoptoze u različitim tipovima ćelija. U ovom radu je izučavana uloga sistema FasR/FasL u patogenezi mijeloproliferativnih neoplazija. Upoređena je ekspresija FasR i FasL između pacijenata sa MPN (24) i zdravih kontrola korišćenjem metode 'real-time' PCR. Detektovana je povećana ekspresija FasR kod pacijenata sa MPN. Nije utvrđena razlika u ekspresiji FasL. Mutacija B617F u JAK2 genu, karakteristična za MPN, je nađena kod 13 od 24 pacijenta. Pokazano je da ekspresija FasR i FasL nije povezana sa prisustvom B617F JAK2 mutacije. AB - Myeloproliferative neoplasms (MPN) are hematological malignancies characterized by uncontrolled cell proliferation and impaired apoptosis. The FasR/FasL system is involved in the control of apoptosis in different cell types. Here we have investigated the role of FasR/FasL in the pathogenesis of MPNs. We compared FasR/FasL expression between MPN patients (24) and healthy individuals using the real-time PCR assay. We found an increase of FasR expression in MPN patients. No difference was detected in FasL expression. Mutation V617F in the JAK2 gene, a hallmark of MPN, was detected in 13/24 patients. We found that neither FasR nor FasL expression were related to the presence of JAK2 V617F mutation. PB - Srpsko biološko društvo, Beograd, i dr. T2 - Archives of Biological Sciences T1 - Uloga sistema FasR/FasL u patogenezi mijeloproliferativnih neoplazija T1 - The role of FasR/FasL system in pathogenesis of myeloprolyferative neoplasms EP - 230 IS - 2 SP - 223 VL - 62 DO - 10.2298/ABS1002223S ER -
@article{ author = "Spasovski, Vesna and Tošić, Nataša and Kostić, Tatjana and Zukić, Branka and Stojiljković, Maja and Čolović, Milica and Pavlović, Sonja", year = "2010", abstract = "Mijeloproliferativne neoplazije (MPN) su hematološki maligniteti koji se karakterišu nekontrolisanom ćelijskom proliferacijom i poremećajem u procesu apoptoze. Sistem FasR/FasL je uključen u kontrolu apoptoze u različitim tipovima ćelija. U ovom radu je izučavana uloga sistema FasR/FasL u patogenezi mijeloproliferativnih neoplazija. Upoređena je ekspresija FasR i FasL između pacijenata sa MPN (24) i zdravih kontrola korišćenjem metode 'real-time' PCR. Detektovana je povećana ekspresija FasR kod pacijenata sa MPN. Nije utvrđena razlika u ekspresiji FasL. Mutacija B617F u JAK2 genu, karakteristična za MPN, je nađena kod 13 od 24 pacijenta. Pokazano je da ekspresija FasR i FasL nije povezana sa prisustvom B617F JAK2 mutacije., Myeloproliferative neoplasms (MPN) are hematological malignancies characterized by uncontrolled cell proliferation and impaired apoptosis. The FasR/FasL system is involved in the control of apoptosis in different cell types. Here we have investigated the role of FasR/FasL in the pathogenesis of MPNs. We compared FasR/FasL expression between MPN patients (24) and healthy individuals using the real-time PCR assay. We found an increase of FasR expression in MPN patients. No difference was detected in FasL expression. Mutation V617F in the JAK2 gene, a hallmark of MPN, was detected in 13/24 patients. We found that neither FasR nor FasL expression were related to the presence of JAK2 V617F mutation.", publisher = "Srpsko biološko društvo, Beograd, i dr.", journal = "Archives of Biological Sciences", title = "Uloga sistema FasR/FasL u patogenezi mijeloproliferativnih neoplazija, The role of FasR/FasL system in pathogenesis of myeloprolyferative neoplasms", pages = "230-223", number = "2", volume = "62", doi = "10.2298/ABS1002223S" }
Spasovski, V., Tošić, N., Kostić, T., Zukić, B., Stojiljković, M., Čolović, M.,& Pavlović, S.. (2010). Uloga sistema FasR/FasL u patogenezi mijeloproliferativnih neoplazija. in Archives of Biological Sciences Srpsko biološko društvo, Beograd, i dr.., 62(2), 223-230. https://doi.org/10.2298/ABS1002223S
Spasovski V, Tošić N, Kostić T, Zukić B, Stojiljković M, Čolović M, Pavlović S. Uloga sistema FasR/FasL u patogenezi mijeloproliferativnih neoplazija. in Archives of Biological Sciences. 2010;62(2):223-230. doi:10.2298/ABS1002223S .
Spasovski, Vesna, Tošić, Nataša, Kostić, Tatjana, Zukić, Branka, Stojiljković, Maja, Čolović, Milica, Pavlović, Sonja, "Uloga sistema FasR/FasL u patogenezi mijeloproliferativnih neoplazija" in Archives of Biological Sciences, 62, no. 2 (2010):223-230, https://doi.org/10.2298/ABS1002223S . .