Inherited Thrombophilia is Associated With Pregnancy Losses That Occur After 12th Gestational Week in Serbian Population
2010
Authors
Mitić, GoranaKovač, Mirjana
Povazan, Ljubica
Magić, Zvonko
Đorđević, Valentina
Salatić, Iva
Mitić, Igor
Novakov-Mikić, Aleksandra
Article (Published version)
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Recurrent fetal loss (RFL) is a significant clinical problem, occurring in 1% to 5% of reproductive females. Inherited or acquired thrombophilia has been diagnosed in 50% to 65% of women with history of unexplained fetal loss. The objective of our study was to determine the prevalence of thrombophilia in women with unexplained RFL in Serbian population and to find out whether the presence of thrombophilia is associated with pregnancy losses that occur later than 12th gestational week. We have examined 147 women with unexplained RFL or intrauterine fetal death and 128 healthy women with at least 1 uncomplicated pregnancy. The antithrombin (AT), protein C (PC), protein S (PS), activated protein C (APC) resistance, factor V (FV) G1691A, factor II (FII) G20210A, and MTHFR C677T were determined. At least 1 inherited thrombophilic defect was found in 54 (36.7%) of 147 women with repeated fetal losses and in 11 (8.59%) of 128 controls (P lt .001, OR 6.17, 95% CI 3.06-12.48). The most common... thrombophilic abnormalities were homozygosity for MTHFR 677TT, FV Leiden, and FII G20210A. Deficiency of natural anticoagulants occurred in 10 patients, with protein S deficiency being the most frequent one. Thrombophilia was found in 46 of 94 women with RFL that occurred later than the 12th gestational week and in only 8 of 53 with RPL earlier than 12th week (P = .001). Our study has shown the association between the hereditary thrombophilia and RFL that occurred after the 12th gestational week in Serbian population.
Keywords:
thrombophilia / recurrent abortion / gene polymorphisms / clinical thrombophiliaSource:
Clinical and Applied Thrombosis-Hemostasis, 2010, 16, 4, 435-439Publisher:
- Sage Publications Inc, Thousand Oaks
DOI: 10.1177/1076029609335518
ISSN: 1076-0296
PubMed: 19520681
WoS: 000280131300009
Scopus: 2-s2.0-77954925938
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Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Mitić, Gorana AU - Kovač, Mirjana AU - Povazan, Ljubica AU - Magić, Zvonko AU - Đorđević, Valentina AU - Salatić, Iva AU - Mitić, Igor AU - Novakov-Mikić, Aleksandra PY - 2010 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/461 AB - Recurrent fetal loss (RFL) is a significant clinical problem, occurring in 1% to 5% of reproductive females. Inherited or acquired thrombophilia has been diagnosed in 50% to 65% of women with history of unexplained fetal loss. The objective of our study was to determine the prevalence of thrombophilia in women with unexplained RFL in Serbian population and to find out whether the presence of thrombophilia is associated with pregnancy losses that occur later than 12th gestational week. We have examined 147 women with unexplained RFL or intrauterine fetal death and 128 healthy women with at least 1 uncomplicated pregnancy. The antithrombin (AT), protein C (PC), protein S (PS), activated protein C (APC) resistance, factor V (FV) G1691A, factor II (FII) G20210A, and MTHFR C677T were determined. At least 1 inherited thrombophilic defect was found in 54 (36.7%) of 147 women with repeated fetal losses and in 11 (8.59%) of 128 controls (P lt .001, OR 6.17, 95% CI 3.06-12.48). The most common thrombophilic abnormalities were homozygosity for MTHFR 677TT, FV Leiden, and FII G20210A. Deficiency of natural anticoagulants occurred in 10 patients, with protein S deficiency being the most frequent one. Thrombophilia was found in 46 of 94 women with RFL that occurred later than the 12th gestational week and in only 8 of 53 with RPL earlier than 12th week (P = .001). Our study has shown the association between the hereditary thrombophilia and RFL that occurred after the 12th gestational week in Serbian population. PB - Sage Publications Inc, Thousand Oaks T2 - Clinical and Applied Thrombosis-Hemostasis T1 - Inherited Thrombophilia is Associated With Pregnancy Losses That Occur After 12th Gestational Week in Serbian Population EP - 439 IS - 4 SP - 435 VL - 16 DO - 10.1177/1076029609335518 ER -
@article{ author = "Mitić, Gorana and Kovač, Mirjana and Povazan, Ljubica and Magić, Zvonko and Đorđević, Valentina and Salatić, Iva and Mitić, Igor and Novakov-Mikić, Aleksandra", year = "2010", abstract = "Recurrent fetal loss (RFL) is a significant clinical problem, occurring in 1% to 5% of reproductive females. Inherited or acquired thrombophilia has been diagnosed in 50% to 65% of women with history of unexplained fetal loss. The objective of our study was to determine the prevalence of thrombophilia in women with unexplained RFL in Serbian population and to find out whether the presence of thrombophilia is associated with pregnancy losses that occur later than 12th gestational week. We have examined 147 women with unexplained RFL or intrauterine fetal death and 128 healthy women with at least 1 uncomplicated pregnancy. The antithrombin (AT), protein C (PC), protein S (PS), activated protein C (APC) resistance, factor V (FV) G1691A, factor II (FII) G20210A, and MTHFR C677T were determined. At least 1 inherited thrombophilic defect was found in 54 (36.7%) of 147 women with repeated fetal losses and in 11 (8.59%) of 128 controls (P lt .001, OR 6.17, 95% CI 3.06-12.48). The most common thrombophilic abnormalities were homozygosity for MTHFR 677TT, FV Leiden, and FII G20210A. Deficiency of natural anticoagulants occurred in 10 patients, with protein S deficiency being the most frequent one. Thrombophilia was found in 46 of 94 women with RFL that occurred later than the 12th gestational week and in only 8 of 53 with RPL earlier than 12th week (P = .001). Our study has shown the association between the hereditary thrombophilia and RFL that occurred after the 12th gestational week in Serbian population.", publisher = "Sage Publications Inc, Thousand Oaks", journal = "Clinical and Applied Thrombosis-Hemostasis", title = "Inherited Thrombophilia is Associated With Pregnancy Losses That Occur After 12th Gestational Week in Serbian Population", pages = "439-435", number = "4", volume = "16", doi = "10.1177/1076029609335518" }
Mitić, G., Kovač, M., Povazan, L., Magić, Z., Đorđević, V., Salatić, I., Mitić, I.,& Novakov-Mikić, A.. (2010). Inherited Thrombophilia is Associated With Pregnancy Losses That Occur After 12th Gestational Week in Serbian Population. in Clinical and Applied Thrombosis-Hemostasis Sage Publications Inc, Thousand Oaks., 16(4), 435-439. https://doi.org/10.1177/1076029609335518
Mitić G, Kovač M, Povazan L, Magić Z, Đorđević V, Salatić I, Mitić I, Novakov-Mikić A. Inherited Thrombophilia is Associated With Pregnancy Losses That Occur After 12th Gestational Week in Serbian Population. in Clinical and Applied Thrombosis-Hemostasis. 2010;16(4):435-439. doi:10.1177/1076029609335518 .
Mitić, Gorana, Kovač, Mirjana, Povazan, Ljubica, Magić, Zvonko, Đorđević, Valentina, Salatić, Iva, Mitić, Igor, Novakov-Mikić, Aleksandra, "Inherited Thrombophilia is Associated With Pregnancy Losses That Occur After 12th Gestational Week in Serbian Population" in Clinical and Applied Thrombosis-Hemostasis, 16, no. 4 (2010):435-439, https://doi.org/10.1177/1076029609335518 . .