Combined effect of GSTM1 gene deletion, GSTT1 gene deletion and MTHFR C677T mutation in male infertility
2010
Преузимање 🢃
Аутори
Đorđević, ValentinaNikolić, Aleksandra
Ljujić, Mila
Nestorović, A.
Ristanović, M.
Tulić, C.
Radojković, Dragica
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The aim of the study was to investigate the association between the GSTM1 and GSTT1 gene deletion and MTHFR C677T mutation and male infertility. The study has encompassed 52 infertile and 56 fertile males. Genotype distributions of GSTM1 and GSTT1 gene deletions and the MTHFR C677T mutation did not differ significantly among the analyzed groups, however, a difference in distribution of certain genotype combinations was observed. The obtained results indicate that carriers of double GSTM1/GSTT1 deletion and the MTHFR 677CC genotype are at higher risk of infertility than carriers of any other combination of genotypes (OR 3.5, 95%CI 0.68-18.30).
Кључне речи:
MTHFR / male infertility / GSTT1 / GSTM1 / gene mutationИзвор:
Archives of Biological Sciences, 2010, 62, 3, 525-530Издавач:
- Srpsko biološko društvo, Beograd, i dr.
Финансирање / пројекти:
- Структурални елементи генома у модулацији фенотипа (RS-MESTD-MPN2006-2010-143051)
DOI: 10.2298/ABS1003525D
ISSN: 0354-4664
WoS: 000281482000002
Scopus: 2-s2.0-77955185599
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Đorđević, Valentina AU - Nikolić, Aleksandra AU - Ljujić, Mila AU - Nestorović, A. AU - Ristanović, M. AU - Tulić, C. AU - Radojković, Dragica PY - 2010 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/464 AB - The aim of the study was to investigate the association between the GSTM1 and GSTT1 gene deletion and MTHFR C677T mutation and male infertility. The study has encompassed 52 infertile and 56 fertile males. Genotype distributions of GSTM1 and GSTT1 gene deletions and the MTHFR C677T mutation did not differ significantly among the analyzed groups, however, a difference in distribution of certain genotype combinations was observed. The obtained results indicate that carriers of double GSTM1/GSTT1 deletion and the MTHFR 677CC genotype are at higher risk of infertility than carriers of any other combination of genotypes (OR 3.5, 95%CI 0.68-18.30). PB - Srpsko biološko društvo, Beograd, i dr. T2 - Archives of Biological Sciences T1 - Combined effect of GSTM1 gene deletion, GSTT1 gene deletion and MTHFR C677T mutation in male infertility EP - 530 IS - 3 SP - 525 VL - 62 DO - 10.2298/ABS1003525D ER -
@article{ author = "Đorđević, Valentina and Nikolić, Aleksandra and Ljujić, Mila and Nestorović, A. and Ristanović, M. and Tulić, C. and Radojković, Dragica", year = "2010", abstract = "The aim of the study was to investigate the association between the GSTM1 and GSTT1 gene deletion and MTHFR C677T mutation and male infertility. The study has encompassed 52 infertile and 56 fertile males. Genotype distributions of GSTM1 and GSTT1 gene deletions and the MTHFR C677T mutation did not differ significantly among the analyzed groups, however, a difference in distribution of certain genotype combinations was observed. The obtained results indicate that carriers of double GSTM1/GSTT1 deletion and the MTHFR 677CC genotype are at higher risk of infertility than carriers of any other combination of genotypes (OR 3.5, 95%CI 0.68-18.30).", publisher = "Srpsko biološko društvo, Beograd, i dr.", journal = "Archives of Biological Sciences", title = "Combined effect of GSTM1 gene deletion, GSTT1 gene deletion and MTHFR C677T mutation in male infertility", pages = "530-525", number = "3", volume = "62", doi = "10.2298/ABS1003525D" }
Đorđević, V., Nikolić, A., Ljujić, M., Nestorović, A., Ristanović, M., Tulić, C.,& Radojković, D.. (2010). Combined effect of GSTM1 gene deletion, GSTT1 gene deletion and MTHFR C677T mutation in male infertility. in Archives of Biological Sciences Srpsko biološko društvo, Beograd, i dr.., 62(3), 525-530. https://doi.org/10.2298/ABS1003525D
Đorđević V, Nikolić A, Ljujić M, Nestorović A, Ristanović M, Tulić C, Radojković D. Combined effect of GSTM1 gene deletion, GSTT1 gene deletion and MTHFR C677T mutation in male infertility. in Archives of Biological Sciences. 2010;62(3):525-530. doi:10.2298/ABS1003525D .
Đorđević, Valentina, Nikolić, Aleksandra, Ljujić, Mila, Nestorović, A., Ristanović, M., Tulić, C., Radojković, Dragica, "Combined effect of GSTM1 gene deletion, GSTT1 gene deletion and MTHFR C677T mutation in male infertility" in Archives of Biological Sciences, 62, no. 3 (2010):525-530, https://doi.org/10.2298/ABS1003525D . .