Angiotensin-Converting Enzyme Gene Insertion/Deletion Polymorphism in Patients with Chronic Pancreatitis and Pancreatic Cancer
Само за регистроване кориснике
2011
Аутори
Lukić, SnežanaNikolić, Aleksandra
Alempijević, Tamara
Popović, Dragan
Sokic Milutinović, Aleksandra
Ugljesić, Milenko
Knezević, Srbislav
Milicić, Biljana
Dinić, Dragica
Radojković, Dragica
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The purpose of this study was to determine the frequency of angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and to investigate its role as a potential risk factor in patients with chronic pancreatitis and pancreatic cancer. Deletion polymorphism of the 287-bp fragment of intron 16 of the ACE gene results in higher levels of circulating enzyme and therefore may represent a risk factor for disease development. The study included 55 patients with chronic pancreatitis, 45 patients with pancreatic cancer and 128 healthy subjects. The presence of I and D variants in the ACE gene was analyzed by a polymerase chain reaction (PCR) method. Distribution of ACE ID genotypes was analyzed by means of logistic regression. When chronic pancreatitis and pancreatic cancer groups were compared in the univariate analysis, the following factors were identified as statistically significant predictors of pancreatic disease: age, gender, smoking, fat intake, ACE II genotype and ...ACE DD genotype. However, in the multivariate analysis, only age, gender and smoking were singled out as predictors for the occurrence of pancreatic disease. Our findings indicate that the ACE I/D polymorphism could play a role in the development of chronic pancreatitis and pancreatic cancer through interaction with other genetic and environmental factors.
Кључне речи:
Pancreatic cancer / Chronic pancreatitis / Angiotensin-converting enzymeИзвор:
Digestive Surgery, 2011, 28, 4, 258-262Издавач:
- Karger, Basel
Финансирање / пројекти:
- Структурални елементи генома у модулацији фенотипа (RS-MESTD-MPN2006-2010-143051)
DOI: 10.1159/000328666
ISSN: 0253-4886
PubMed: 21654174
WoS: 000296514800004
Scopus: 2-s2.0-79957930570
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Lukić, Snežana AU - Nikolić, Aleksandra AU - Alempijević, Tamara AU - Popović, Dragan AU - Sokic Milutinović, Aleksandra AU - Ugljesić, Milenko AU - Knezević, Srbislav AU - Milicić, Biljana AU - Dinić, Dragica AU - Radojković, Dragica PY - 2011 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/489 AB - The purpose of this study was to determine the frequency of angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and to investigate its role as a potential risk factor in patients with chronic pancreatitis and pancreatic cancer. Deletion polymorphism of the 287-bp fragment of intron 16 of the ACE gene results in higher levels of circulating enzyme and therefore may represent a risk factor for disease development. The study included 55 patients with chronic pancreatitis, 45 patients with pancreatic cancer and 128 healthy subjects. The presence of I and D variants in the ACE gene was analyzed by a polymerase chain reaction (PCR) method. Distribution of ACE ID genotypes was analyzed by means of logistic regression. When chronic pancreatitis and pancreatic cancer groups were compared in the univariate analysis, the following factors were identified as statistically significant predictors of pancreatic disease: age, gender, smoking, fat intake, ACE II genotype and ACE DD genotype. However, in the multivariate analysis, only age, gender and smoking were singled out as predictors for the occurrence of pancreatic disease. Our findings indicate that the ACE I/D polymorphism could play a role in the development of chronic pancreatitis and pancreatic cancer through interaction with other genetic and environmental factors. PB - Karger, Basel T2 - Digestive Surgery T1 - Angiotensin-Converting Enzyme Gene Insertion/Deletion Polymorphism in Patients with Chronic Pancreatitis and Pancreatic Cancer EP - 262 IS - 4 SP - 258 VL - 28 DO - 10.1159/000328666 ER -
@article{ author = "Lukić, Snežana and Nikolić, Aleksandra and Alempijević, Tamara and Popović, Dragan and Sokic Milutinović, Aleksandra and Ugljesić, Milenko and Knezević, Srbislav and Milicić, Biljana and Dinić, Dragica and Radojković, Dragica", year = "2011", abstract = "The purpose of this study was to determine the frequency of angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and to investigate its role as a potential risk factor in patients with chronic pancreatitis and pancreatic cancer. Deletion polymorphism of the 287-bp fragment of intron 16 of the ACE gene results in higher levels of circulating enzyme and therefore may represent a risk factor for disease development. The study included 55 patients with chronic pancreatitis, 45 patients with pancreatic cancer and 128 healthy subjects. The presence of I and D variants in the ACE gene was analyzed by a polymerase chain reaction (PCR) method. Distribution of ACE ID genotypes was analyzed by means of logistic regression. When chronic pancreatitis and pancreatic cancer groups were compared in the univariate analysis, the following factors were identified as statistically significant predictors of pancreatic disease: age, gender, smoking, fat intake, ACE II genotype and ACE DD genotype. However, in the multivariate analysis, only age, gender and smoking were singled out as predictors for the occurrence of pancreatic disease. Our findings indicate that the ACE I/D polymorphism could play a role in the development of chronic pancreatitis and pancreatic cancer through interaction with other genetic and environmental factors.", publisher = "Karger, Basel", journal = "Digestive Surgery", title = "Angiotensin-Converting Enzyme Gene Insertion/Deletion Polymorphism in Patients with Chronic Pancreatitis and Pancreatic Cancer", pages = "262-258", number = "4", volume = "28", doi = "10.1159/000328666" }
Lukić, S., Nikolić, A., Alempijević, T., Popović, D., Sokic Milutinović, A., Ugljesić, M., Knezević, S., Milicić, B., Dinić, D.,& Radojković, D.. (2011). Angiotensin-Converting Enzyme Gene Insertion/Deletion Polymorphism in Patients with Chronic Pancreatitis and Pancreatic Cancer. in Digestive Surgery Karger, Basel., 28(4), 258-262. https://doi.org/10.1159/000328666
Lukić S, Nikolić A, Alempijević T, Popović D, Sokic Milutinović A, Ugljesić M, Knezević S, Milicić B, Dinić D, Radojković D. Angiotensin-Converting Enzyme Gene Insertion/Deletion Polymorphism in Patients with Chronic Pancreatitis and Pancreatic Cancer. in Digestive Surgery. 2011;28(4):258-262. doi:10.1159/000328666 .
Lukić, Snežana, Nikolić, Aleksandra, Alempijević, Tamara, Popović, Dragan, Sokic Milutinović, Aleksandra, Ugljesić, Milenko, Knezević, Srbislav, Milicić, Biljana, Dinić, Dragica, Radojković, Dragica, "Angiotensin-Converting Enzyme Gene Insertion/Deletion Polymorphism in Patients with Chronic Pancreatitis and Pancreatic Cancer" in Digestive Surgery, 28, no. 4 (2011):258-262, https://doi.org/10.1159/000328666 . .