Astrocytes in the tempest of multiple sclerosis
Abstract
Astrocytes are the most abundant cell population within the CNS of mammals. Their glial role is perfectly performed in the healthy CNS as they support functions of neurons. The omnipresence of astrocytes throughout the white and grey matter and their intimate relation with blood vessels of the CNS, as well as numerous immunity-related actions that these cells are capable of, imply that astrocytes should have a prominent role in neuroinflammatory disorders, such as multiple sclerosis (MS). The role of astrocytes in MS is rather ambiguous, as they have the capacity to both stimulate and restrain neuroinflammation and tissue destruction. In this paper we present some of the proved and the proposed functions of astrocytes in neuroinflammation and discuss the effect of MS therapeutics on astrocytes.
Keywords:
Neuroinflammation / Multiple sclerosis / Extracellular matrix / Blood-brain barrier / AstrocyteSource:
FEBS Letters, 2011, 585, 23, 3781-3788Publisher:
- Wiley, Hoboken
Funding / projects:
- Cellular and molecular mechanisms of recovery of rats from experimental autoimmune encephalomyelitis (RS-MESTD-Basic Research (BR or ON)-173035)
DOI: 10.1016/j.febslet.2011.03.047
ISSN: 1873-3468
PubMed: 21443873
WoS: 000297318000024
Scopus: 2-s2.0-81755179433
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Institution/Community
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Miljković, Djordje AU - Timotijević, Gordana AU - Mostarica-Stojković, Marija PY - 2011 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/491 AB - Astrocytes are the most abundant cell population within the CNS of mammals. Their glial role is perfectly performed in the healthy CNS as they support functions of neurons. The omnipresence of astrocytes throughout the white and grey matter and their intimate relation with blood vessels of the CNS, as well as numerous immunity-related actions that these cells are capable of, imply that astrocytes should have a prominent role in neuroinflammatory disorders, such as multiple sclerosis (MS). The role of astrocytes in MS is rather ambiguous, as they have the capacity to both stimulate and restrain neuroinflammation and tissue destruction. In this paper we present some of the proved and the proposed functions of astrocytes in neuroinflammation and discuss the effect of MS therapeutics on astrocytes. PB - Wiley, Hoboken T2 - FEBS Letters T1 - Astrocytes in the tempest of multiple sclerosis EP - 3788 IS - 23 SP - 3781 VL - 585 DO - 10.1016/j.febslet.2011.03.047 ER -
@article{ author = "Miljković, Djordje and Timotijević, Gordana and Mostarica-Stojković, Marija", year = "2011", abstract = "Astrocytes are the most abundant cell population within the CNS of mammals. Their glial role is perfectly performed in the healthy CNS as they support functions of neurons. The omnipresence of astrocytes throughout the white and grey matter and their intimate relation with blood vessels of the CNS, as well as numerous immunity-related actions that these cells are capable of, imply that astrocytes should have a prominent role in neuroinflammatory disorders, such as multiple sclerosis (MS). The role of astrocytes in MS is rather ambiguous, as they have the capacity to both stimulate and restrain neuroinflammation and tissue destruction. In this paper we present some of the proved and the proposed functions of astrocytes in neuroinflammation and discuss the effect of MS therapeutics on astrocytes.", publisher = "Wiley, Hoboken", journal = "FEBS Letters", title = "Astrocytes in the tempest of multiple sclerosis", pages = "3788-3781", number = "23", volume = "585", doi = "10.1016/j.febslet.2011.03.047" }
Miljković, D., Timotijević, G.,& Mostarica-Stojković, M.. (2011). Astrocytes in the tempest of multiple sclerosis. in FEBS Letters Wiley, Hoboken., 585(23), 3781-3788. https://doi.org/10.1016/j.febslet.2011.03.047
Miljković D, Timotijević G, Mostarica-Stojković M. Astrocytes in the tempest of multiple sclerosis. in FEBS Letters. 2011;585(23):3781-3788. doi:10.1016/j.febslet.2011.03.047 .
Miljković, Djordje, Timotijević, Gordana, Mostarica-Stojković, Marija, "Astrocytes in the tempest of multiple sclerosis" in FEBS Letters, 585, no. 23 (2011):3781-3788, https://doi.org/10.1016/j.febslet.2011.03.047 . .