New polyene macrolide family produced by submerged culture of Streptomyces durmitorensis
2011
Autori
Stodulkova, EvaKuzma, Marek
Hench, Ivana Bratic
Cerny, Jan
Kralova, Jarmila
Novak, Petr
Chudickova, Milada
Savić, Miloje
Đokić, Lidija
Vasiljević, Branka
Flieger, Miroslav
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
A new polyene macrolide family, closely related to the pentaene macrolide antibiotic roflamycoin, was isolated from the both fermentation broth and biomass of Streptomyces durmitorensis wild-type strain MS405. The main compound was identified by NMR and Fourier transform ion cyclotron resonance mass spectrometry as 32,33-didehydroroflamycoin (1; DDHR). Additional four structurally related compounds were determined solely by MS analysis. DDHR induces cell death by apoptosis in various cancer cell lines as demonstrated by DNA fragmentation. Striking feature of DDHR is its internal fluorescence allowing visualization of labeled plasma membranes and internal membrane structures. The Journal of Antibiotics (2011) 64, 717-722; doi:10.1038/ja.2011.81; published online 14 September 2011
Ključne reči:
structure elucidation / Streptomyces durmitorensis / polyene macrolide / NMR / FTMS / apoptosisIzvor:
Journal of Antibiotics, 2011, 64, 11, 717-722Izdavač:
- Nature Publishing Group, London
Finansiranje / projekti:
- Institutional Research Concept [AV 0Z502 00510]
- Center of Molecular and Cellular Immunology [1M6837805001 nda MSM0021620858]
- Ministry of Education Youth and Sport [2B08064]
- Ekspresija i regulacija farmaceutski značajnih gena u mikroorganizmima (RS-MESTD-MPN2006-2010-143056)
- Serbian Academy of Sciences
- Academy of Sciences of the Czech Republic
DOI: 10.1038/ja.2011.81
ISSN: 0021-8820
PubMed: 21915134
WoS: 000297791100003
Scopus: 2-s2.0-82355172967
Institucija/grupa
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Stodulkova, Eva AU - Kuzma, Marek AU - Hench, Ivana Bratic AU - Cerny, Jan AU - Kralova, Jarmila AU - Novak, Petr AU - Chudickova, Milada AU - Savić, Miloje AU - Đokić, Lidija AU - Vasiljević, Branka AU - Flieger, Miroslav PY - 2011 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/492 AB - A new polyene macrolide family, closely related to the pentaene macrolide antibiotic roflamycoin, was isolated from the both fermentation broth and biomass of Streptomyces durmitorensis wild-type strain MS405. The main compound was identified by NMR and Fourier transform ion cyclotron resonance mass spectrometry as 32,33-didehydroroflamycoin (1; DDHR). Additional four structurally related compounds were determined solely by MS analysis. DDHR induces cell death by apoptosis in various cancer cell lines as demonstrated by DNA fragmentation. Striking feature of DDHR is its internal fluorescence allowing visualization of labeled plasma membranes and internal membrane structures. The Journal of Antibiotics (2011) 64, 717-722; doi:10.1038/ja.2011.81; published online 14 September 2011 PB - Nature Publishing Group, London T2 - Journal of Antibiotics T1 - New polyene macrolide family produced by submerged culture of Streptomyces durmitorensis EP - 722 IS - 11 SP - 717 VL - 64 DO - 10.1038/ja.2011.81 ER -
@article{ author = "Stodulkova, Eva and Kuzma, Marek and Hench, Ivana Bratic and Cerny, Jan and Kralova, Jarmila and Novak, Petr and Chudickova, Milada and Savić, Miloje and Đokić, Lidija and Vasiljević, Branka and Flieger, Miroslav", year = "2011", abstract = "A new polyene macrolide family, closely related to the pentaene macrolide antibiotic roflamycoin, was isolated from the both fermentation broth and biomass of Streptomyces durmitorensis wild-type strain MS405. The main compound was identified by NMR and Fourier transform ion cyclotron resonance mass spectrometry as 32,33-didehydroroflamycoin (1; DDHR). Additional four structurally related compounds were determined solely by MS analysis. DDHR induces cell death by apoptosis in various cancer cell lines as demonstrated by DNA fragmentation. Striking feature of DDHR is its internal fluorescence allowing visualization of labeled plasma membranes and internal membrane structures. The Journal of Antibiotics (2011) 64, 717-722; doi:10.1038/ja.2011.81; published online 14 September 2011", publisher = "Nature Publishing Group, London", journal = "Journal of Antibiotics", title = "New polyene macrolide family produced by submerged culture of Streptomyces durmitorensis", pages = "722-717", number = "11", volume = "64", doi = "10.1038/ja.2011.81" }
Stodulkova, E., Kuzma, M., Hench, I. B., Cerny, J., Kralova, J., Novak, P., Chudickova, M., Savić, M., Đokić, L., Vasiljević, B.,& Flieger, M.. (2011). New polyene macrolide family produced by submerged culture of Streptomyces durmitorensis. in Journal of Antibiotics Nature Publishing Group, London., 64(11), 717-722. https://doi.org/10.1038/ja.2011.81
Stodulkova E, Kuzma M, Hench IB, Cerny J, Kralova J, Novak P, Chudickova M, Savić M, Đokić L, Vasiljević B, Flieger M. New polyene macrolide family produced by submerged culture of Streptomyces durmitorensis. in Journal of Antibiotics. 2011;64(11):717-722. doi:10.1038/ja.2011.81 .
Stodulkova, Eva, Kuzma, Marek, Hench, Ivana Bratic, Cerny, Jan, Kralova, Jarmila, Novak, Petr, Chudickova, Milada, Savić, Miloje, Đokić, Lidija, Vasiljević, Branka, Flieger, Miroslav, "New polyene macrolide family produced by submerged culture of Streptomyces durmitorensis" in Journal of Antibiotics, 64, no. 11 (2011):717-722, https://doi.org/10.1038/ja.2011.81 . .