Muscle ankyrin repeat proteins: their role in striated muscle function in health and disease
Само за регистроване кориснике
2011
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Remodeling is a stringently controlled process that enables adequate response of muscle cells to constant physical stresses. In this process, different kinds of stimuli have to be sensed and converted into biochemical signals that ultimately lead to alterations of muscle phenotype. Several multiprotein complexes located in the sarcomere and organized on the titin molecular spring have been identified as stress sensors and signal transducers. In this review, we focus on Ankrd1/CARP and Ankrd2/Arpp proteins, which belong to the muscle ankyrin repeat protein family (MARP) involved in a mechano-signaling pathway that links myofibrillar stress response to muscle gene expression. Apart from the mechanosensory function, they have an important role in transcriptional regulation, myofibrillar assembly, cardiogenesis and myogenesis. Their altered expression has been demonstrated in neuromuscular disorders, cardiovascular diseases, as well as in tumors, suggesting a role in pathological processes.... Although analyzed in a limited number of patients, there is a considerable body of evidence that MARP proteins could be suitable candidates for prognostic and diagnostic biomarkers.
Кључне речи:
tumors / Sarcomere / motor neuron diseases / mechanosensors / inherited myopathies / cardiomyopathies / Ankrd2/Arpp / Ankrd1/CARPИзвор:
Critical Reviews in Clinical Laboratory Sciences, 2011, 48, 5-6, 269-294Издавач:
- Taylor & Francis Ltd, Abingdon
Финансирање / пројекти:
- ICGEB, Italy [CRP/YUG-05-01]
- Telethon Foundation of Italy [GGP04088]
- Fondazione Cariparo, Italy
- Структурални елементи генома у модулацији фенотипа (RS-MESTD-MPN2006-2010-143051)
- Комплексне болести као модел систем за проучавање модулације фенотипа-структурна и функционална анализа молекуларних биомаркера (RS-MESTD-Basic Research (BR or ON)-173008)
DOI: 10.3109/10408363.2011.643857
ISSN: 1040-8363
PubMed: 22185618
WoS: 000298294800004
Scopus: 2-s2.0-84055197774
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Kojić, Snežana AU - Radojković, Dragica AU - Faulkner, Georgine PY - 2011 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/493 AB - Remodeling is a stringently controlled process that enables adequate response of muscle cells to constant physical stresses. In this process, different kinds of stimuli have to be sensed and converted into biochemical signals that ultimately lead to alterations of muscle phenotype. Several multiprotein complexes located in the sarcomere and organized on the titin molecular spring have been identified as stress sensors and signal transducers. In this review, we focus on Ankrd1/CARP and Ankrd2/Arpp proteins, which belong to the muscle ankyrin repeat protein family (MARP) involved in a mechano-signaling pathway that links myofibrillar stress response to muscle gene expression. Apart from the mechanosensory function, they have an important role in transcriptional regulation, myofibrillar assembly, cardiogenesis and myogenesis. Their altered expression has been demonstrated in neuromuscular disorders, cardiovascular diseases, as well as in tumors, suggesting a role in pathological processes. Although analyzed in a limited number of patients, there is a considerable body of evidence that MARP proteins could be suitable candidates for prognostic and diagnostic biomarkers. PB - Taylor & Francis Ltd, Abingdon T2 - Critical Reviews in Clinical Laboratory Sciences T1 - Muscle ankyrin repeat proteins: their role in striated muscle function in health and disease EP - 294 IS - 5-6 SP - 269 VL - 48 DO - 10.3109/10408363.2011.643857 ER -
@article{ author = "Kojić, Snežana and Radojković, Dragica and Faulkner, Georgine", year = "2011", abstract = "Remodeling is a stringently controlled process that enables adequate response of muscle cells to constant physical stresses. In this process, different kinds of stimuli have to be sensed and converted into biochemical signals that ultimately lead to alterations of muscle phenotype. Several multiprotein complexes located in the sarcomere and organized on the titin molecular spring have been identified as stress sensors and signal transducers. In this review, we focus on Ankrd1/CARP and Ankrd2/Arpp proteins, which belong to the muscle ankyrin repeat protein family (MARP) involved in a mechano-signaling pathway that links myofibrillar stress response to muscle gene expression. Apart from the mechanosensory function, they have an important role in transcriptional regulation, myofibrillar assembly, cardiogenesis and myogenesis. Their altered expression has been demonstrated in neuromuscular disorders, cardiovascular diseases, as well as in tumors, suggesting a role in pathological processes. Although analyzed in a limited number of patients, there is a considerable body of evidence that MARP proteins could be suitable candidates for prognostic and diagnostic biomarkers.", publisher = "Taylor & Francis Ltd, Abingdon", journal = "Critical Reviews in Clinical Laboratory Sciences", title = "Muscle ankyrin repeat proteins: their role in striated muscle function in health and disease", pages = "294-269", number = "5-6", volume = "48", doi = "10.3109/10408363.2011.643857" }
Kojić, S., Radojković, D.,& Faulkner, G.. (2011). Muscle ankyrin repeat proteins: their role in striated muscle function in health and disease. in Critical Reviews in Clinical Laboratory Sciences Taylor & Francis Ltd, Abingdon., 48(5-6), 269-294. https://doi.org/10.3109/10408363.2011.643857
Kojić S, Radojković D, Faulkner G. Muscle ankyrin repeat proteins: their role in striated muscle function in health and disease. in Critical Reviews in Clinical Laboratory Sciences. 2011;48(5-6):269-294. doi:10.3109/10408363.2011.643857 .
Kojić, Snežana, Radojković, Dragica, Faulkner, Georgine, "Muscle ankyrin repeat proteins: their role in striated muscle function in health and disease" in Critical Reviews in Clinical Laboratory Sciences, 48, no. 5-6 (2011):269-294, https://doi.org/10.3109/10408363.2011.643857 . .