Transcriptional regulation and pharmacogenomics
Abstract
Interindividual variable drug response is correlated with sequence alterations in genes encoding drug-metabolizing enzymes and transporters, affecting drug absorption, distribution, metabolism and excretion. This variable drug response may have an impact on disease therapeutic outcomes, tolerance to adverse drug reactions and even survival. Sequence alterations may occur not only within the coding region of a gene, but in its regulatory elements too, affecting gene transcription and gene-expression levels. Here, we provide a compilation of the current knowledge of pharmacogenomics related to transcription, with a focus on the effect of SNPs and short tandem repeats residing in cis-regulatory elements of 11 genes encoding for drug-metabolizing enzymes and drug transporters. In addition, we comment on two genes encoding enzymes that are drug targets themselves. Finally, we briefly discuss the currently available methodologies for clinically assessing pharmacogenomic profiles, which could... potentially in the future facilitate drug treatment-individualization via the identification of molecular signatures in specific patient groups.
Keywords:
transcription / transcription profiling / SNP / pharmacogenomics / gene regulationSource:
Pharmacogenomics, 2011, 12, 5, 655-673Publisher:
- Future Medicine Ltd, London
Funding / projects:
- European Commission [FP6-31968, GEN2PHEN FP7-200754]
- Rare Diseases:Molecular Pathophysiology, Diagnostic and Therapeutic Modalities and Social, Ethical and Legal Aspects (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41004)
- State Scholarships Foundation (IKY)
DOI: 10.2217/PGS.10.215
ISSN: 1462-2416
PubMed: 21619428
WoS: 000292128900004
Scopus: 2-s2.0-79955704159
Collections
Institution/Community
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Georgitsi, Marianthi AU - Zukić, Branka AU - Pavlović, Sonja AU - Patrinos, George P. PY - 2011 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/510 AB - Interindividual variable drug response is correlated with sequence alterations in genes encoding drug-metabolizing enzymes and transporters, affecting drug absorption, distribution, metabolism and excretion. This variable drug response may have an impact on disease therapeutic outcomes, tolerance to adverse drug reactions and even survival. Sequence alterations may occur not only within the coding region of a gene, but in its regulatory elements too, affecting gene transcription and gene-expression levels. Here, we provide a compilation of the current knowledge of pharmacogenomics related to transcription, with a focus on the effect of SNPs and short tandem repeats residing in cis-regulatory elements of 11 genes encoding for drug-metabolizing enzymes and drug transporters. In addition, we comment on two genes encoding enzymes that are drug targets themselves. Finally, we briefly discuss the currently available methodologies for clinically assessing pharmacogenomic profiles, which could potentially in the future facilitate drug treatment-individualization via the identification of molecular signatures in specific patient groups. PB - Future Medicine Ltd, London T2 - Pharmacogenomics T1 - Transcriptional regulation and pharmacogenomics EP - 673 IS - 5 SP - 655 VL - 12 DO - 10.2217/PGS.10.215 ER -
@article{ author = "Georgitsi, Marianthi and Zukić, Branka and Pavlović, Sonja and Patrinos, George P.", year = "2011", abstract = "Interindividual variable drug response is correlated with sequence alterations in genes encoding drug-metabolizing enzymes and transporters, affecting drug absorption, distribution, metabolism and excretion. This variable drug response may have an impact on disease therapeutic outcomes, tolerance to adverse drug reactions and even survival. Sequence alterations may occur not only within the coding region of a gene, but in its regulatory elements too, affecting gene transcription and gene-expression levels. Here, we provide a compilation of the current knowledge of pharmacogenomics related to transcription, with a focus on the effect of SNPs and short tandem repeats residing in cis-regulatory elements of 11 genes encoding for drug-metabolizing enzymes and drug transporters. In addition, we comment on two genes encoding enzymes that are drug targets themselves. Finally, we briefly discuss the currently available methodologies for clinically assessing pharmacogenomic profiles, which could potentially in the future facilitate drug treatment-individualization via the identification of molecular signatures in specific patient groups.", publisher = "Future Medicine Ltd, London", journal = "Pharmacogenomics", title = "Transcriptional regulation and pharmacogenomics", pages = "673-655", number = "5", volume = "12", doi = "10.2217/PGS.10.215" }
Georgitsi, M., Zukić, B., Pavlović, S.,& Patrinos, G. P.. (2011). Transcriptional regulation and pharmacogenomics. in Pharmacogenomics Future Medicine Ltd, London., 12(5), 655-673. https://doi.org/10.2217/PGS.10.215
Georgitsi M, Zukić B, Pavlović S, Patrinos GP. Transcriptional regulation and pharmacogenomics. in Pharmacogenomics. 2011;12(5):655-673. doi:10.2217/PGS.10.215 .
Georgitsi, Marianthi, Zukić, Branka, Pavlović, Sonja, Patrinos, George P., "Transcriptional regulation and pharmacogenomics" in Pharmacogenomics, 12, no. 5 (2011):655-673, https://doi.org/10.2217/PGS.10.215 . .