Acute Myeloid Leukemia Associated With Near-Tetraploid Karyotype and Mutations in the FLT3 Gene
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2011
Аутори
Jurisić, Vladimir![](/themes/Mirageimagine/images/orcid.png)
Pavlović, Sonja
![](/themes/Mirageimagine/images/orcid.png)
Čolović, Nataša
Đorđević, Vesna
Janković, Gradimir
Colović, Milica
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Tetraploidy and near-tetraploidy are rare in acute myeloid leukemia (AML), contrary to other hematological disease. In this paper we describe a case of a 52-year-old male with AML associated with tetraploidy, mutation in tyrosine kinase receptor FLT3, and very short survival. At presentation maculopapular rash with crustae, lymphadenopathy, and hepatosplenomegaly was diagnosed. The blasts comprised 80% of marrow nucleated cells (POX negative and PAS finely granular positive). Immunophenotyping done on marrow cells was (CD34, HLA DR, CD14, CD64, CD33, CD11b, and CD15) and correlated with the acute monoblastic leukemia. Detection of FLT3 mutation was done by polymerase chain reaction (PCR). Cytogenetic analysis show: 85-93. XXYY,inc(cp5)/46,XY. Based on these considerations, we suggest the detection of FLT3 mutations as a diagnostic procedure for all AML patients.
Кључне речи:
tetraploidy / survival / FLT3 mutation / clinical presentation / acute myeloid leukemiaИзвор:
Laboratory Medicine, 2011, 42, 9, 540-543Издавач:
- Amer Soc Clinical Pathology, Chicago
Финансирање / пројекти:
- Молекулске, биохемијске и имунолошке анализе у дијагностици тумора (RS-MESTD-Basic Research (BR or ON)-175056)
DOI: 10.1309/LM6E0CQQPOKXXG4E
ISSN: 0007-5027
WoS: 000294277700004
Scopus: 2-s2.0-80052646168
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Jurisić, Vladimir AU - Pavlović, Sonja AU - Čolović, Nataša AU - Đorđević, Vesna AU - Janković, Gradimir AU - Colović, Milica PY - 2011 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/525 AB - Tetraploidy and near-tetraploidy are rare in acute myeloid leukemia (AML), contrary to other hematological disease. In this paper we describe a case of a 52-year-old male with AML associated with tetraploidy, mutation in tyrosine kinase receptor FLT3, and very short survival. At presentation maculopapular rash with crustae, lymphadenopathy, and hepatosplenomegaly was diagnosed. The blasts comprised 80% of marrow nucleated cells (POX negative and PAS finely granular positive). Immunophenotyping done on marrow cells was (CD34, HLA DR, CD14, CD64, CD33, CD11b, and CD15) and correlated with the acute monoblastic leukemia. Detection of FLT3 mutation was done by polymerase chain reaction (PCR). Cytogenetic analysis show: 85-93. XXYY,inc(cp5)/46,XY. Based on these considerations, we suggest the detection of FLT3 mutations as a diagnostic procedure for all AML patients. PB - Amer Soc Clinical Pathology, Chicago T2 - Laboratory Medicine T1 - Acute Myeloid Leukemia Associated With Near-Tetraploid Karyotype and Mutations in the FLT3 Gene EP - 543 IS - 9 SP - 540 VL - 42 DO - 10.1309/LM6E0CQQPOKXXG4E ER -
@article{ author = "Jurisić, Vladimir and Pavlović, Sonja and Čolović, Nataša and Đorđević, Vesna and Janković, Gradimir and Colović, Milica", year = "2011", abstract = "Tetraploidy and near-tetraploidy are rare in acute myeloid leukemia (AML), contrary to other hematological disease. In this paper we describe a case of a 52-year-old male with AML associated with tetraploidy, mutation in tyrosine kinase receptor FLT3, and very short survival. At presentation maculopapular rash with crustae, lymphadenopathy, and hepatosplenomegaly was diagnosed. The blasts comprised 80% of marrow nucleated cells (POX negative and PAS finely granular positive). Immunophenotyping done on marrow cells was (CD34, HLA DR, CD14, CD64, CD33, CD11b, and CD15) and correlated with the acute monoblastic leukemia. Detection of FLT3 mutation was done by polymerase chain reaction (PCR). Cytogenetic analysis show: 85-93. XXYY,inc(cp5)/46,XY. Based on these considerations, we suggest the detection of FLT3 mutations as a diagnostic procedure for all AML patients.", publisher = "Amer Soc Clinical Pathology, Chicago", journal = "Laboratory Medicine", title = "Acute Myeloid Leukemia Associated With Near-Tetraploid Karyotype and Mutations in the FLT3 Gene", pages = "543-540", number = "9", volume = "42", doi = "10.1309/LM6E0CQQPOKXXG4E" }
Jurisić, V., Pavlović, S., Čolović, N., Đorđević, V., Janković, G.,& Colović, M.. (2011). Acute Myeloid Leukemia Associated With Near-Tetraploid Karyotype and Mutations in the FLT3 Gene. in Laboratory Medicine Amer Soc Clinical Pathology, Chicago., 42(9), 540-543. https://doi.org/10.1309/LM6E0CQQPOKXXG4E
Jurisić V, Pavlović S, Čolović N, Đorđević V, Janković G, Colović M. Acute Myeloid Leukemia Associated With Near-Tetraploid Karyotype and Mutations in the FLT3 Gene. in Laboratory Medicine. 2011;42(9):540-543. doi:10.1309/LM6E0CQQPOKXXG4E .
Jurisić, Vladimir, Pavlović, Sonja, Čolović, Nataša, Đorđević, Vesna, Janković, Gradimir, Colović, Milica, "Acute Myeloid Leukemia Associated With Near-Tetraploid Karyotype and Mutations in the FLT3 Gene" in Laboratory Medicine, 42, no. 9 (2011):540-543, https://doi.org/10.1309/LM6E0CQQPOKXXG4E . .