Members of the CREB/ATF and AP1 family of transcription factors are involved in the regulation of SOX18 gene expression
2011
Authors
Petrović, IsidoraKovačević Grujičić, Nataša
Popović, Jelena
Krstić, A.
Milivojević, Milena
Stevanović, Milena
Article (Published version)
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Show full item recordAbstract
The SOX18 transcription factor plays an important role in endothelial cell specification, angiogenesis and atherogenesis. By profiling transcription factor interactions (TranSignal TM TF Protein Array) we identified several transcription factors implicated in angiogenesis that have the ability to bind to the SOX18 optimal promoter region in vitro. In this report we focused our attention on distinct transcription factors identified by the array as belonging to AP-1 and CREB/ATF protein families. In particular, we analyzed the effects of CREB, JunB, c-Jun and ATF3 on SOX18 gene expression. Functional analysis revealed that CREB acts as a repressor, while JunB, c-Jun and ATF3 act as activators of SOX18 promoter activity. Our findings indicate that a transcriptional network that includes CREB, JunB, c-Jun and ATF3 could be involved in angiogenesis-related transcriptional regulation of the SOX18 gene.
Keywords:
SOX18 / CREB/ATF / AP-1 / angiogenesisSource:
Archives of Biological Sciences, 2011, 63, 3, 517-525Publisher:
- Srpsko biološko društvo, Beograd, i dr.
Funding / projects:
- International Centre for Genetic Engineering and Biotechnology [CRP/YUG 07-01]
- Izučavanje regulacije ekspresije i funkcije humanih SOX gena (RS-MESTD-MPN2006-2010-143028)
- Studying signal transduction pathways and epigenetic mechanisms that control human SOX genes expression: further insight into their roles in cell fate determination and differentiation (RS-MESTD-Basic Research (BR or ON)-173051)
DOI: 10.2298/ABS1103517P
ISSN: 0354-4664
WoS: 000294400500001
Scopus: 2-s2.0-79961196024
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Institution/Community
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Petrović, Isidora AU - Kovačević Grujičić, Nataša AU - Popović, Jelena AU - Krstić, A. AU - Milivojević, Milena AU - Stevanović, Milena PY - 2011 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/526 AB - The SOX18 transcription factor plays an important role in endothelial cell specification, angiogenesis and atherogenesis. By profiling transcription factor interactions (TranSignal TM TF Protein Array) we identified several transcription factors implicated in angiogenesis that have the ability to bind to the SOX18 optimal promoter region in vitro. In this report we focused our attention on distinct transcription factors identified by the array as belonging to AP-1 and CREB/ATF protein families. In particular, we analyzed the effects of CREB, JunB, c-Jun and ATF3 on SOX18 gene expression. Functional analysis revealed that CREB acts as a repressor, while JunB, c-Jun and ATF3 act as activators of SOX18 promoter activity. Our findings indicate that a transcriptional network that includes CREB, JunB, c-Jun and ATF3 could be involved in angiogenesis-related transcriptional regulation of the SOX18 gene. PB - Srpsko biološko društvo, Beograd, i dr. T2 - Archives of Biological Sciences T1 - Members of the CREB/ATF and AP1 family of transcription factors are involved in the regulation of SOX18 gene expression EP - 525 IS - 3 SP - 517 VL - 63 DO - 10.2298/ABS1103517P ER -
@article{ author = "Petrović, Isidora and Kovačević Grujičić, Nataša and Popović, Jelena and Krstić, A. and Milivojević, Milena and Stevanović, Milena", year = "2011", abstract = "The SOX18 transcription factor plays an important role in endothelial cell specification, angiogenesis and atherogenesis. By profiling transcription factor interactions (TranSignal TM TF Protein Array) we identified several transcription factors implicated in angiogenesis that have the ability to bind to the SOX18 optimal promoter region in vitro. In this report we focused our attention on distinct transcription factors identified by the array as belonging to AP-1 and CREB/ATF protein families. In particular, we analyzed the effects of CREB, JunB, c-Jun and ATF3 on SOX18 gene expression. Functional analysis revealed that CREB acts as a repressor, while JunB, c-Jun and ATF3 act as activators of SOX18 promoter activity. Our findings indicate that a transcriptional network that includes CREB, JunB, c-Jun and ATF3 could be involved in angiogenesis-related transcriptional regulation of the SOX18 gene.", publisher = "Srpsko biološko društvo, Beograd, i dr.", journal = "Archives of Biological Sciences", title = "Members of the CREB/ATF and AP1 family of transcription factors are involved in the regulation of SOX18 gene expression", pages = "525-517", number = "3", volume = "63", doi = "10.2298/ABS1103517P" }
Petrović, I., Kovačević Grujičić, N., Popović, J., Krstić, A., Milivojević, M.,& Stevanović, M.. (2011). Members of the CREB/ATF and AP1 family of transcription factors are involved in the regulation of SOX18 gene expression. in Archives of Biological Sciences Srpsko biološko društvo, Beograd, i dr.., 63(3), 517-525. https://doi.org/10.2298/ABS1103517P
Petrović I, Kovačević Grujičić N, Popović J, Krstić A, Milivojević M, Stevanović M. Members of the CREB/ATF and AP1 family of transcription factors are involved in the regulation of SOX18 gene expression. in Archives of Biological Sciences. 2011;63(3):517-525. doi:10.2298/ABS1103517P .
Petrović, Isidora, Kovačević Grujičić, Nataša, Popović, Jelena, Krstić, A., Milivojević, Milena, Stevanović, Milena, "Members of the CREB/ATF and AP1 family of transcription factors are involved in the regulation of SOX18 gene expression" in Archives of Biological Sciences, 63, no. 3 (2011):517-525, https://doi.org/10.2298/ABS1103517P . .