CXCL12: Role in neuroinflammation
Само за регистроване кориснике
2012
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
CxCL12, also known as SDF-1 (stromal cell derived factor-1) is a small protein that belongs to the chemokine family, whose members have a crucial role in directing cell migration. CXCL12 has an essential role in neural and vascular development, hematopoiesis and in immunity. It acts through two receptors. CXCR4 and CXCR7. While the former is a classic G protein-coupled transmembrane chemokine receptor, the latter primarily function as a scavenger of CXCL12. CXCL12 has been considered as a standard proinflammatory molecule for a long time, as it attracts leukocytes to inflammatory sites and contributes to their activation. However, recent findings indicate that this chemokine has the opposite role in neuroinflammation. In this review, basic data about molecular and functional properties of CXCL12 are presented, while its role in CNS autoimmunity is addressed in details.
Кључне речи:
Neuroinflammation / Multiple sclerosis / Immunology / Chemokine / AutoimmunityИзвор:
International Journal of Biochemistry & Cell Biology, 2012, 44, 6, 838-841Издавач:
- Pergamon-Elsevier Science Ltd, Oxford
Финансирање / пројекти:
- Ћелијски и молекулски механизми опоравка пацова од експерименталног аутоимунског енцефаломијелитиса (RS-MESTD-Basic Research (BR or ON)-173035)
- Имунопатогенетски и регулаторни механизми у аутоимунским болестима и хроничној инфламацији (RS-MESTD-Basic Research (BR or ON)-175038)
- Молекуларни механизми физиолошке и фармаколошке контроле инфламације и канцера (RS-MESTD-Basic Research (BR or ON)-173013)
- Молекуларни механизми одговора биљака на абиотички стрес-улога транскрипционих фактора и малих РНК и анализа генетичког диверзитета биљних култура од интереса за пољопривреду и биотехнологију (RS-MESTD-Basic Research (BR or ON)-173005)
DOI: 10.1016/j.biocel.2012.03.014
ISSN: 1357-2725
PubMed: 22484430
WoS: 000304490700004
Scopus: 2-s2.0-84860284492
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Timotijević, Gordana AU - Mostarica-Stojković, Marija AU - Miljković, Djordje PY - 2012 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/558 AB - CxCL12, also known as SDF-1 (stromal cell derived factor-1) is a small protein that belongs to the chemokine family, whose members have a crucial role in directing cell migration. CXCL12 has an essential role in neural and vascular development, hematopoiesis and in immunity. It acts through two receptors. CXCR4 and CXCR7. While the former is a classic G protein-coupled transmembrane chemokine receptor, the latter primarily function as a scavenger of CXCL12. CXCL12 has been considered as a standard proinflammatory molecule for a long time, as it attracts leukocytes to inflammatory sites and contributes to their activation. However, recent findings indicate that this chemokine has the opposite role in neuroinflammation. In this review, basic data about molecular and functional properties of CXCL12 are presented, while its role in CNS autoimmunity is addressed in details. PB - Pergamon-Elsevier Science Ltd, Oxford T2 - International Journal of Biochemistry & Cell Biology T1 - CXCL12: Role in neuroinflammation EP - 841 IS - 6 SP - 838 VL - 44 DO - 10.1016/j.biocel.2012.03.014 ER -
@article{ author = "Timotijević, Gordana and Mostarica-Stojković, Marija and Miljković, Djordje", year = "2012", abstract = "CxCL12, also known as SDF-1 (stromal cell derived factor-1) is a small protein that belongs to the chemokine family, whose members have a crucial role in directing cell migration. CXCL12 has an essential role in neural and vascular development, hematopoiesis and in immunity. It acts through two receptors. CXCR4 and CXCR7. While the former is a classic G protein-coupled transmembrane chemokine receptor, the latter primarily function as a scavenger of CXCL12. CXCL12 has been considered as a standard proinflammatory molecule for a long time, as it attracts leukocytes to inflammatory sites and contributes to their activation. However, recent findings indicate that this chemokine has the opposite role in neuroinflammation. In this review, basic data about molecular and functional properties of CXCL12 are presented, while its role in CNS autoimmunity is addressed in details.", publisher = "Pergamon-Elsevier Science Ltd, Oxford", journal = "International Journal of Biochemistry & Cell Biology", title = "CXCL12: Role in neuroinflammation", pages = "841-838", number = "6", volume = "44", doi = "10.1016/j.biocel.2012.03.014" }
Timotijević, G., Mostarica-Stojković, M.,& Miljković, D.. (2012). CXCL12: Role in neuroinflammation. in International Journal of Biochemistry & Cell Biology Pergamon-Elsevier Science Ltd, Oxford., 44(6), 838-841. https://doi.org/10.1016/j.biocel.2012.03.014
Timotijević G, Mostarica-Stojković M, Miljković D. CXCL12: Role in neuroinflammation. in International Journal of Biochemistry & Cell Biology. 2012;44(6):838-841. doi:10.1016/j.biocel.2012.03.014 .
Timotijević, Gordana, Mostarica-Stojković, Marija, Miljković, Djordje, "CXCL12: Role in neuroinflammation" in International Journal of Biochemistry & Cell Biology, 44, no. 6 (2012):838-841, https://doi.org/10.1016/j.biocel.2012.03.014 . .