CXCL12: Role in neuroinflammation
Samo za registrovane korisnike
2012
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
CxCL12, also known as SDF-1 (stromal cell derived factor-1) is a small protein that belongs to the chemokine family, whose members have a crucial role in directing cell migration. CXCL12 has an essential role in neural and vascular development, hematopoiesis and in immunity. It acts through two receptors. CXCR4 and CXCR7. While the former is a classic G protein-coupled transmembrane chemokine receptor, the latter primarily function as a scavenger of CXCL12. CXCL12 has been considered as a standard proinflammatory molecule for a long time, as it attracts leukocytes to inflammatory sites and contributes to their activation. However, recent findings indicate that this chemokine has the opposite role in neuroinflammation. In this review, basic data about molecular and functional properties of CXCL12 are presented, while its role in CNS autoimmunity is addressed in details.
Ključne reči:
Neuroinflammation / Multiple sclerosis / Immunology / Chemokine / AutoimmunityIzvor:
International Journal of Biochemistry & Cell Biology, 2012, 44, 6, 838-841Izdavač:
- Pergamon-Elsevier Science Ltd, Oxford
Finansiranje / projekti:
- Ćelijski i molekulski mehanizmi oporavka pacova od eksperimentalnog autoimunskog encefalomijelitisa (RS-MESTD-Basic Research (BR or ON)-173035)
- Imunopatogenetski i regulatorni mehanizmi u autoimunskim bolestima i hroničnoj inflamaciji (RS-MESTD-Basic Research (BR or ON)-175038)
- Molekularni mehanizmi fiziološke i farmakološke kontrole inflamacije i kancera (RS-MESTD-Basic Research (BR or ON)-173013)
- Molekularni mehanizmi odgovora biljaka na abiotički stres-uloga transkripcionih faktora i malih RNK i analiza genetičkog diverziteta biljnih kultura od interesa za poljoprivredu i biotehnologiju (RS-MESTD-Basic Research (BR or ON)-173005)
DOI: 10.1016/j.biocel.2012.03.014
ISSN: 1357-2725
PubMed: 22484430
WoS: 000304490700004
Scopus: 2-s2.0-84860284492
Institucija/grupa
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Timotijević, Gordana AU - Mostarica-Stojković, Marija AU - Miljković, Djordje PY - 2012 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/558 AB - CxCL12, also known as SDF-1 (stromal cell derived factor-1) is a small protein that belongs to the chemokine family, whose members have a crucial role in directing cell migration. CXCL12 has an essential role in neural and vascular development, hematopoiesis and in immunity. It acts through two receptors. CXCR4 and CXCR7. While the former is a classic G protein-coupled transmembrane chemokine receptor, the latter primarily function as a scavenger of CXCL12. CXCL12 has been considered as a standard proinflammatory molecule for a long time, as it attracts leukocytes to inflammatory sites and contributes to their activation. However, recent findings indicate that this chemokine has the opposite role in neuroinflammation. In this review, basic data about molecular and functional properties of CXCL12 are presented, while its role in CNS autoimmunity is addressed in details. PB - Pergamon-Elsevier Science Ltd, Oxford T2 - International Journal of Biochemistry & Cell Biology T1 - CXCL12: Role in neuroinflammation EP - 841 IS - 6 SP - 838 VL - 44 DO - 10.1016/j.biocel.2012.03.014 ER -
@article{ author = "Timotijević, Gordana and Mostarica-Stojković, Marija and Miljković, Djordje", year = "2012", abstract = "CxCL12, also known as SDF-1 (stromal cell derived factor-1) is a small protein that belongs to the chemokine family, whose members have a crucial role in directing cell migration. CXCL12 has an essential role in neural and vascular development, hematopoiesis and in immunity. It acts through two receptors. CXCR4 and CXCR7. While the former is a classic G protein-coupled transmembrane chemokine receptor, the latter primarily function as a scavenger of CXCL12. CXCL12 has been considered as a standard proinflammatory molecule for a long time, as it attracts leukocytes to inflammatory sites and contributes to their activation. However, recent findings indicate that this chemokine has the opposite role in neuroinflammation. In this review, basic data about molecular and functional properties of CXCL12 are presented, while its role in CNS autoimmunity is addressed in details.", publisher = "Pergamon-Elsevier Science Ltd, Oxford", journal = "International Journal of Biochemistry & Cell Biology", title = "CXCL12: Role in neuroinflammation", pages = "841-838", number = "6", volume = "44", doi = "10.1016/j.biocel.2012.03.014" }
Timotijević, G., Mostarica-Stojković, M.,& Miljković, D.. (2012). CXCL12: Role in neuroinflammation. in International Journal of Biochemistry & Cell Biology Pergamon-Elsevier Science Ltd, Oxford., 44(6), 838-841. https://doi.org/10.1016/j.biocel.2012.03.014
Timotijević G, Mostarica-Stojković M, Miljković D. CXCL12: Role in neuroinflammation. in International Journal of Biochemistry & Cell Biology. 2012;44(6):838-841. doi:10.1016/j.biocel.2012.03.014 .
Timotijević, Gordana, Mostarica-Stojković, Marija, Miljković, Djordje, "CXCL12: Role in neuroinflammation" in International Journal of Biochemistry & Cell Biology, 44, no. 6 (2012):838-841, https://doi.org/10.1016/j.biocel.2012.03.014 . .